Leflunomide is immunomodulator drugs with applications in managing rheumatoid arthritis. In this study, four new analogs (4A-D) A771726, active metabolites of Leflunomide were synthesized and examined in vitro for their immunomodulation activities by examining the proliferation of human lymphocytes and determining the concentration of interferon-gamma cytokines in human lymphocyte cell culture.

For this purpose, 5 x 10 (4) human lymphocyte cells are incubated at 37 degrees C within 5% CO (2) with phytohemagglutinin and one analog (concentration of 1-100 mm), negative control or cyclosporine (0.1 mm). The effects of compounds on lymphocyte proliferation and interferon-gamma production are determined by the MTT test and immunosorben test related to enzymes. Our results show that the four compounds of the dependent proliferation of lymphocytes are pressed.

In addition, these compounds at several concentrations reduce the production of interferon-gamma which is an indicator of the immune response. In general, the most powerful analog is 4b with an amida link (x = NH) and the weakest analog is 4A with esters (x = o). 4A compound has a little similarity with the active metabolit of Leflunomide which has amide relationships. In this study, four new compounds were synthesized which showed a fairly large immunosuppressive effect that deserved further investigation.

Complete Combined Inhibition and CD14 ABOLISH E. Cytokine Synthesis, Kemokin and Coli-induced growth in all human blood.

Relative Complementary Role and CD14 in the synthesis of cytokines induced by E. coli in the overall human blood model in vitro examined. All freshly lepirudin-anticoagulation blood is incubated with E. coli for 2 hours. Monoclonal antibodies or C5A receptor antagonists are used to block complement. Inflammatory mediators (n = 27) are measured by multiplex technology, selected cytokine mRNA with real time PCR, and CD11b, oxidative burst and phagocytosis with the flow of cytometry. E. coli significantly increased 18 out of 27 inflammatory mediators, including proinflammatory cytokines (TNF-Alpha, IL-6, Inf-Gamma and IL-1beta), Kemokin (IL-8, MCP-1, MIP-1Alpha, MIP-1beta , Eotaxin and IP-10), growth factor (VEGF, FGF-BASIC, G-CSF and GM-CSF) and other interleukin (IL-9, IL-15 and IL-17).

In particular, the increase in all mediators was abolished by the combined inhibition of CD14 and complementary using anti-C2 and anti-factor in combination, while the relative effects of inhibition of complement and CD14 varied. In comparison, C5A and anti-CD14 receptor antagonists in combination reduce cytokine synthesis is less efficient. The real time PCR analysis confirms that cytokine synthesis is blocked at the level of the MRNA. Similarly, E. CD11b is induced by CD11B up-regulation, oxidative explosion and phagocytosis is completely hampered by CD14, anti-C2 and anti-factor D in combination after 2-hour incubation. In conclusion, the inhibition of complementary combined using anti-C2, anti-factor D and CD14 almost completely inhibits the inflammatory response induced by E. coli. Therefore a combined approach can be a new treatment regimen in gram-negative sepsis.

Antibodies anti-CD25 affect the synthesis pattern of cytokines of human dendritic cells and reduce their ability to prime allogenic t cells.

Anti-CD25 monoclonal antibodies are widely used in clinical transplants to prevent acute refusal allograft. Although the effect on T lymphocytes has been studied extensively, the impact on human dendritic cells (DC) has never been reported. Furthermore, the IL-2 role in the DC function has not been fully explained. In this study, we confirmed that the stimulation of DC monocyte-human derivative with LP greatly induces CD25 expression and that DC maturity of LPS also states the beta chain and Gamma IL-2R.

We also show that adding monoclonal antibodies anti-CD25 for LPS that induce decreased IL-12, IL-1, TNF-Alpha, IL-6, and IFN-gamma production and an increase in IL-10 synthesis by DC compared to stimulation. with LPS only. Furthermore, we show that this modification reduces the priming capability of DC helper and polarized alllimun response to Th2. Conversely, minoclonal antibodies anti-CD25 which are humble do not affect CD86, CD80, CD83, HLADR, or CD40 regulations which are induced in LPS stimulation. Taken together, this study revealed several effects previously not recognized by anti-CD25 monoclonal antibodies in DC which could contribute to their clinical efficacy. In addition, this study also explained the role of IL-2 in human DC activation.

The anti-CD25 treatment of human dendritic cells modulates both of their cytokine synthesis profiles and its capacity to activate allogeneic T cells: potential tolerogenic effects.

Recently, attention has focused on the role of dendritic cells (DCS) in the promotion of peripheral tolerance. Currently it is believed that the state of the DCS maturation / activation may be a control point for the induction of graft tolerance through modification of cell activation T. We have observed the expression of IL-2 receptor gene, and IL-2 with reverse polymerase transcriptase reaction (RT-PCR) In DC human lysate after bacterial stimulation. It has been shown in this study IL-2R Alpha (CD25) expression on human DCS on LPS activation.

IL-10, Interleukin-10, rat
RC252-21	Bio Basic	2ug	EUR 125.26

Simian Interleukin 10(IL-10)
QY-E110087	Qayee Biotechnology	96T	EUR 526.8

Interleukin 10 Antibody / IL-10
RQ7264	NSJ Bioreagents	100ug	EUR 419

IL-10 Peptide
43-526P	ProSci	0.1 mg	EUR 405.6

IL-10 Antibody
BF0175	Affbiotech	200ul	EUR 540

rHu IL-10
AK8273-0002	Akron Biotech	2µg	Ask for price

rHu IL-10
AK8273-0010	Akron Biotech	10µg	Ask for price

rHu IL-10
AK8273-0100	Akron Biotech	100µg	Ask for price

rHu IL-10
AK8273-1000	Akron Biotech	1mg	Ask for price

IL-10 Antibody
6638-100	Biovision	each	EUR 418.8

IL-10 Antibody
6638-30T	Biovision	each	EUR 175.2

IL-10 Antibody
F51527-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

IL-10 Antibody
F51527-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

His-IL-10
E13-019-1	EnoGene	10μg	EUR 193.2

His-IL-10
E13-019-2	EnoGene	50μg	EUR 606

IL-10, Human
HY-P7030	MedChemExpress	50ug	EUR 914.4

IL-10, Rat
HY-P7098	MedChemExpress	50ug	EUR 872.4

IL-10 Antibody
R30421	NSJ Bioreagents	100 ug	EUR 356.15
Description: Interleukin-10, also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse il10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32.

Il-10 Antibody
RQ6187	NSJ Bioreagents	100 ug	EUR 356.15
Description: Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNF-alpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse IL 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32.

Il-10 Antibody
RQ4389	NSJ Bioreagents	100 ug	EUR 356.15
Description: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. [UniProt]

IL-10 Antibody
RQ4550	NSJ Bioreagents	100ug	EUR 356.15
Description: Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFNg, IL-2, IL-3, TNFa and GM-CSF made by cells such as macrophages and regulatory T-cells.IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al. (1992) showed that the mouse Il 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al. (1997) mapped the IL10 gene to the junction between 1q31 and 1q32.

IL-10 Antibody
V7295-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

IL-10 Antibody
V7295-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

IL-10 Antibody
V7295IHC-7ML	NSJ Bioreagents	7 ml	EUR 349.3
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

IL-10 Antibody
V7295SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Human Interleukin-10 (IL-10) Antibody
13109-05011	AssayPro	150 ug	EUR 260.4

Recombinant Human Interleukin-10/IL-10
CX04-10ug	Novoprotein	10ug	EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-10/IL-10
CX04-1mg	Novoprotein	1mg	EUR 2983.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-10/IL-10
CX04-500ug	Novoprotein	500ug	EUR 2106
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human Interleukin-10/IL-10
CX04-50ug	Novoprotein	50ug	EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse Interleukin-10/IL-10
C697-10ug	Novoprotein	10ug	EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Interleukin-10/IL-10
C697-1mg	Novoprotein	1mg	EUR 2983.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Interleukin-10/IL-10
C697-500ug	Novoprotein	500ug	EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Interleukin-10/IL-10
C697-50ug	Novoprotein	50ug	EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

IL-10, Interleukin-10, murine (mouse)
RC232-21	Bio Basic	2ug	EUR 125.26

Horse Interleukin 10 (IL-10) ELISA
QY-E120049	Qayee Biotechnology	96T	EUR 573.6

Human High sensitive IL-10(HS IL-10)ELISA Kit
YLA4321HU-48T	Shanghai YL Biotech	48T	EUR 435

Human High sensitive IL-10(HS IL-10)ELISA Kit
YLA4321HU-96T	Shanghai YL Biotech	96T	EUR 562.5

Polyclonal IL-10 Antibody
APR00338G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-10 . This antibody is tested and proven to work in the following applications:

IL-10 Recombinant Protein
40-253-0002mg	ProSci	0.002 mg	EUR 311.1
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

IL-10 Recombinant Protein
40-253-001mg	ProSci	0.01 mg	EUR 437.1
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

IL-10 Recombinant Protein
40-417-0002mg	ProSci	0.002 mg	EUR 311.1
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.

IL-10 Recombinant Protein
40-417-001mg	ProSci	0.01 mg	EUR 437.1
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.

IL-10 Recombinant Protein
40-471-0002mg	ProSci	0.002 mg	EUR 311.1
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant rat IL-10 is an 18.7 kDa protein of 160 amino acid residues.

IL-10 Recombinant Protein
40-471-001mg	ProSci	0.01 mg	EUR 437.1
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant rat IL-10 is an 18.7 kDa protein of 160 amino acid residues.

IL-10, human recombinant
4155-1000	Biovision	each	EUR 6324

IL-10, human recombinant
4155-50	Biovision	each	EUR 836.4

IL-10 Polyclonal Antibody
41553-100ul	SAB	100ul	EUR 302.4

IL-10 Polyclonal Antibody
41553-50ul	SAB	50ul	EUR 224.4

IL-10, murine recombinant
4156-10	Biovision	each	EUR 294

IL-10, murine recombinant
4156-1000	Biovision	each	EUR 6324

IL-10, murine recombinant
4156-50	Biovision	each	EUR 836.4

IL-10, human recombinant
4155-10	Biovision	each	EUR 294

IL-10, rat recombinant
4157-10	Biovision	each	EUR 360

IL-10, rat recombinant
4157-1000	Biovision	each	EUR 7810.8

IL-10 Blocking Peptide
BF0175-BP	Affbiotech	1mg	EUR 234

rHu IL-10 (cGMP)
AK9819-0000	Akron Biotech	1mg	Ask for price

IL-10 Recombinant Protein
91-582	ProSci	0.05 mg	EUR 821.4
Description: Mouse Il10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. Many viruses encode viral members of the IL-10 family, such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV).Its main function is inhibiting the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Although human and mouse IL-10 are 81% identical at the nucleotide and amino acid level, mouse IL-10 is species-specific and does not act on human cells. Interestingly, Human IL-10 is active on mouse cells.

IL-10 Recombinant Protein
91-880	ProSci	0.05 mg	EUR 821.4
Description: Interleukin 10(IL10), also known as cytokine synthesis inhibitory factor (CSIF),is a secreted protein and belongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokine that has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 in produced in several T helper populations, it is proposed that it provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viable biomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations

IL-10 Recombinant Protein
96-893	ProSci	0.02 mg	EUR 519
Description: Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.

IL-10 Recombinant Protein
97-003	ProSci	0.02 mg	EUR 468.6
Description: Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.

IL-10 Recombinant Protein
90-494	ProSci	10 ug	EUR 468.6
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

IL-10 Recombinant Protein
90-495	ProSci	50 ug	EUR 651.3
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

IL-10 Recombinant Protein
90-498	ProSci	10 ug	EUR 468.6
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

IL-10 Recombinant Protein
90-499	ProSci	50 ug	EUR 1023
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

IL-10 Recombinant Protein
90-555	ProSci	10 ug	EUR 500.1
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

IL-10 Polyclonal Antibody
ABP52869-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of IL-10 from Human. This IL-10 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-10

IL-10 Polyclonal Antibody
ABP52869-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of IL-10 from Human. This IL-10 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-10

IL-10 Polyclonal Antibody
ABP52869-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of IL-10 from Human. This IL-10 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-10

IL-10 Polyclonal Antibody
ES3868-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against IL-10 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IL-10 Polyclonal Antibody
ES3868-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against IL-10 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

anti- IL-10 antibody
FNab04211	FN Test	100µg	EUR 702
Description: Antibody raised against IL-10

anti- IL-10 antibody
FNab04212	FN Test	100µg	EUR 702
Description: Antibody raised against IL-10

anti-IL-10 (3C12C12)
LF-MA30009	Abfrontier	100 ul	EUR 448.8
Description: Mouse Monoclonal to IL-10

Anti-IL-10 antibody
PAab04211	Lifescience Market	100 ug	EUR 494.4

Recombinant Hamster IL-10
P0539	FN Test	100ug	EUR 626.83
Description: Recombinant Hamster protein for IL-10

IL-10 R alpha
GT15185	Neuromics	100 ug	EUR 631.2

rec IL-10 (murine)
H-9715.0002	Bachem	2.0µg	EUR 194.4

rec IL-10 (murine)
H-9715.0010	Bachem	10.0µg	EUR 457.2

Human IL-10 Antibody
R30116	NSJ Bioreagents	100 ug	EUR 356.15
Description: Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor(CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells.IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse IL 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32.

Mouse Il-10 Antibody
R30117	NSJ Bioreagents	100 ug	EUR 356.15
Description: Interleukin-10, also known as human cytokine synthesis inhibitory factor(CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse IL 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32.

Rat Il-10 Antibody
R30118	NSJ Bioreagents	100 ug	EUR 356.15
Description: Interleukin-10 is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells.

Anti-IL-10 antibody
STJ96503	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to IL-10.

Anti-IL-10 antibody
STJ98167	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to IL-10.

Recombinant Human IL-10
HEILP-1001	Cyagen	10ug	Ask for price

Recombinant Murine IL-10
MEILP-1001	Cyagen	10ug	Ask for price

Recombinant Rat IL-10
REILP-1001	Cyagen	10ug	Ask for price

Human Interleukin 10 (IL-10) CLIA Kit
abx195842-96tests	Abbexa	96 tests	EUR 990

Mouse Interleukin 10 (IL-10) CLIA Kit
abx195843-96tests	Abbexa	96 tests	EUR 990

Rat Interleukin 10 (IL-10) CLIA Kit
abx195844-96tests	Abbexa	96 tests	EUR 990

Human Interleukin 10,IL-10 ELISA KIT
201-12-0103	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 10, IL-10 ELISA KIT
CSB-E04593h-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 10, IL-10 in samples from serum, urine, cell culture supernates, asciticfluid, cerebrospinalfluid (CSF), saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 10, IL-10 ELISA KIT
1-CSB-E04593h	Cusabio	EUR 723.60 EUR 5096.40 EUR 2712.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 10, IL-10 in samples from serum, urine, cell culture supernates, asciticfluid, cerebrospinalfluid(CSF), saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse interleukin 10, IL-10 ELISA KIT
CSB-E04594m-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse interleukin 10, IL-10 ELISA KIT
1-CSB-E04594m	Cusabio	EUR 723.60 EUR 5096.40 EUR 2712.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 10, IL-10 ELISA KIT
CSB-E04595r-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 10, IL-10 ELISA KIT
1-CSB-E04595r	Cusabio	EUR 723.60 EUR 5096.40 EUR 2712.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Chicken Interleukin 10 (IL-10) ELISA Kit
DEIABL-CK3	Creative Diagnostics	96T	EUR 752.4
Description: This CD Interleukin 10 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human IL-10. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Goat Interleukin 10, IL-10 ELISA Kit
CSB-E09809g-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Goat Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Goat Interleukin 10, IL-10 ELISA Kit
1-CSB-E09809g	Cusabio	EUR 813.60 EUR 5572.80 EUR 2960.40	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Goat Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Goat Interleukin 10,IL-10 ELISA Kit
CN-00369S1	ChemNorm	96T	EUR 529.2

Rabbit Interleukin 10,IL-10 ELISA Kit
CN-00727R1	ChemNorm	96T	EUR 529.2

Rabbit Interleukin 10,IL-10 ELISA Kit
CN-00727R2	ChemNorm	48T	EUR 349.2

Mouse interleukin 10,IL-10 ELISA KIT
CN-02459M1	ChemNorm	96T	EUR 536.4

Mouse interleukin 10,IL-10 ELISA KIT
CN-02459M2	ChemNorm	48T	EUR 355.2

Human Interleukin 10,IL-10 ELISA KIT
CN-03221H1	ChemNorm	96T	EUR 520.8

Human Interleukin 10,IL-10 ELISA KIT
CN-03221H2	ChemNorm	48T	EUR 340.8

PoFAine interleukin 10,IL-10 ELISA Kit
CN-01259P1	ChemNorm	96T	EUR 564

PoFAine interleukin 10,IL-10 ELISA Kit
CN-01259P2	ChemNorm	48T	EUR 384

Rat Interleukin 10,IL-10 ELISA KIT
CN-01602R1	ChemNorm	96T	EUR 542.4

Rat Interleukin 10,IL-10 ELISA KIT
CN-01602R2	ChemNorm	48T	EUR 362.4

Pig interleukin 10, IL-10 ELISA Kit
CSB-E06779p-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig interleukin 10, IL-10 ELISA Kit
1-CSB-E06779p	Cusabio	EUR 752.40 EUR 5336.40 EUR 2836.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit Interleukin 10, IL-10 ELISA Kit
CSB-E06897Rb-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rabbit Interleukin 10, IL-10 ELISA Kit
1-CSB-E06897Rb	Cusabio	EUR 723.60 EUR 5096.40 EUR 2712.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Sheep Interleukin 10, IL-10 ELISA Kit
CSB-E12817Sh-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Sheep Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Sheep Interleukin 10, IL-10 ELISA Kit
1-CSB-E12817Sh	Cusabio	EUR 1135.20 EUR 6938.40 EUR 3672.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Sheep Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Chicken Interleukin 10, IL-10 ELISA Kit
CSB-E12835C-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Chicken Interleukin 10, IL-10 ELISA Kit
1-CSB-E12835C	Cusabio	EUR 1053.60 EUR 6570.00 EUR 3480.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 10, IL-10 ELISA Kit
CSB-E12917B-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 10, IL-10 ELISA Kit
1-CSB-E12917B	Cusabio	EUR 867.60 EUR 5859.60 EUR 3109.20	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Dog Interleukin 10, IL-10 ELISA Kit
CSB-E11261c-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Dog Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Dog Interleukin 10, IL-10 ELISA Kit
1-CSB-E11261c	Cusabio	EUR 843.60 EUR 5811.60 EUR 3084.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Dog Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Porcine IL-10(Interleukin-10) ELISA Kit
EP0086	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 18.75pg/ml

Monkey IL-10(Interleukin-10) ELISA Kit
EMK0036	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 9.375pg/ml

Rat IL-10(Interleukin-10) ELISA Kit
ER0033	FN Test	96T	EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml

Rabbit IL-10(Interleukin-10) ELISA Kit
ERB0056	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml

Sheep IL-10(Interleukin-10) ELISA Kit
ESH0009	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 9.375pg/ml

Human Interleukin-10 (IL-10) ELISA Kit
LF-EK60026	Abfrontier	1×96T	EUR 948

IL-10 Interleukin-10 Mouse Recombinant Protein
PROTP18893	BosterBio	Regular: 10ug	EUR 380.4
Description: IL-10 Recombinant Mouse produced in E.coli is a single, non-glycosylated polypeptide chain containing 161 amino acids and having a molecular mass of 18785 Dalton. ;The Interleukin-10 Mouse is purified by proprietary chromatographic techniques.

IL-10 Interleukin-10 Human Recombinant Protein
PROTP22301-2	BosterBio	Regular: 10ug	EUR 380.4
Description: Interleukin-10 Human Recombinant produced in E.coli is a single non-glycosylated polypeptide chains containing 161 amino acids each and having a molecular mass of 18.6kDa.;The IL-10 is purified by proprietary chromatographic techniques.

IL-10 Interleukin-10 Rat Recombinant Protein
PROTP29456	BosterBio	Regular: 10ug	EUR 380.4
Description: IL-10 Recombinant Rat produced in E.coli is a single, glycosylated polypeptide chain containing 160 amino acids and having a molecular mass of 18.6 kDa. ;The Interleukin-10 Mouse is purified by proprietary chromatographic techniques.

Mouse interleukin 10(IL-10)ELISA Kit
GA-E0044MS-48T	GenAsia Biotech	48T	EUR 403.2

Mouse interleukin 10(IL-10)ELISA Kit
GA-E0044MS-96T	GenAsia Biotech	96T	EUR 640.8

Rabbit Interleukin 10,IL-10 ELISA Kit
GA-E0111RB-48T	GenAsia Biotech	48T	EUR 391.2

Rabbit Interleukin 10,IL-10 ELISA Kit
GA-E0111RB-96T	GenAsia Biotech	96T	EUR 628.8

DCS is distinguished from monocytes exposed anti-CD25 during maturation, anti-CD25 treatment affects the ability of human DCS to induce CD4 + cell proliferation in responding to alloantigens, maintaining endocytic, anti-CD25 treated capacity to produce low level IL-12 and IFN and high levels of IL-10. All these characteristics show that DC can be used in cellular therapy both to induce allograft tolerance (anti-CD25 treated DCS) or to restore immunity to tumors (IL-2 DCRE).