Leflunomide is immunomodulator drugs with applications in managing rheumatoid arthritis. In this study, four new analogs (4A-D) A771726, active metabolites of Leflunomide were synthesized and examined in vitro for their immunomodulation activities by examining the proliferation of human lymphocytes and determining the concentration of interferon-gamma cytokines in human lymphocyte cell culture.
For this purpose, 5 x 10 (4) human lymphocyte cells are incubated at 37 degrees C within 5% CO (2) with phytohemagglutinin and one analog (concentration of 1-100 mm), negative control or cyclosporine (0.1 mm). The effects of compounds on lymphocyte proliferation and interferon-gamma production are determined by the MTT test and immunosorben test related to enzymes. Our results show that the four compounds of the dependent proliferation of lymphocytes are pressed.
In addition, these compounds at several concentrations reduce the production of interferon-gamma which is an indicator of the immune response. In general, the most powerful analog is 4b with an amida link (x = NH) and the weakest analog is 4A with esters (x = o). 4A compound has a little similarity with the active metabolit of Leflunomide which has amide relationships. In this study, four new compounds were synthesized which showed a fairly large immunosuppressive effect that deserved further investigation.
Complete Combined Inhibition and CD14 ABOLISH E. Cytokine Synthesis, Kemokin and Coli-induced growth in all human blood.
Relative Complementary Role and CD14 in the synthesis of cytokines induced by E. coli in the overall human blood model in vitro examined. All freshly lepirudin-anticoagulation blood is incubated with E. coli for 2 hours. Monoclonal antibodies or C5A receptor antagonists are used to block complement. Inflammatory mediators (n = 27) are measured by multiplex technology, selected cytokine mRNA with real time PCR, and CD11b, oxidative burst and phagocytosis with the flow of cytometry. E. coli significantly increased 18 out of 27 inflammatory mediators, including proinflammatory cytokines (TNF-Alpha, IL-6, Inf-Gamma and IL-1beta), Kemokin (IL-8, MCP-1, MIP-1Alpha, MIP-1beta , Eotaxin and IP-10), growth factor (VEGF, FGF-BASIC, G-CSF and GM-CSF) and other interleukin (IL-9, IL-15 and IL-17).
In particular, the increase in all mediators was abolished by the combined inhibition of CD14 and complementary using anti-C2 and anti-factor in combination, while the relative effects of inhibition of complement and CD14 varied. In comparison, C5A and anti-CD14 receptor antagonists in combination reduce cytokine synthesis is less efficient. The real time PCR analysis confirms that cytokine synthesis is blocked at the level of the MRNA. Similarly, E. CD11b is induced by CD11B up-regulation, oxidative explosion and phagocytosis is completely hampered by CD14, anti-C2 and anti-factor D in combination after 2-hour incubation. In conclusion, the inhibition of complementary combined using anti-C2, anti-factor D and CD14 almost completely inhibits the inflammatory response induced by E. coli. Therefore a combined approach can be a new treatment regimen in gram-negative sepsis.
Antibodies anti-CD25 affect the synthesis pattern of cytokines of human dendritic cells and reduce their ability to prime allogenic t cells.
Anti-CD25 monoclonal antibodies are widely used in clinical transplants to prevent acute refusal allograft. Although the effect on T lymphocytes has been studied extensively, the impact on human dendritic cells (DC) has never been reported. Furthermore, the IL-2 role in the DC function has not been fully explained. In this study, we confirmed that the stimulation of DC monocyte-human derivative with LP greatly induces CD25 expression and that DC maturity of LPS also states the beta chain and Gamma IL-2R.

We also show that adding monoclonal antibodies anti-CD25 for LPS that induce decreased IL-12, IL-1, TNF-Alpha, IL-6, and IFN-gamma production and an increase in IL-10 synthesis by DC compared to stimulation. with LPS only. Furthermore, we show that this modification reduces the priming capability of DC helper and polarized alllimun response to Th2. Conversely, minoclonal antibodies anti-CD25 which are humble do not affect CD86, CD80, CD83, HLADR, or CD40 regulations which are induced in LPS stimulation. Taken together, this study revealed several effects previously not recognized by anti-CD25 monoclonal antibodies in DC which could contribute to their clinical efficacy. In addition, this study also explained the role of IL-2 in human DC activation.
The anti-CD25 treatment of human dendritic cells modulates both of their cytokine synthesis profiles and its capacity to activate allogeneic T cells: potential tolerogenic effects.
Recently, attention has focused on the role of dendritic cells (DCS) in the promotion of peripheral tolerance. Currently it is believed that the state of the DCS maturation / activation may be a control point for the induction of graft tolerance through modification of cell activation T. We have observed the expression of IL-2 receptor gene, and IL-2 with reverse polymerase transcriptase reaction (RT-PCR) In DC human lysate after bacterial stimulation. It has been shown in this study IL-2R Alpha (CD25) expression on human DCS on LPS activation.
IL-10, Interleukin-10, rat |
RC252-21 |
Bio Basic |
2ug |
EUR 125.26 |
|
IL-10 Peptide |
43-526P |
ProSci |
0.1 mg |
EUR 405.6 |
IL-10 Antibody |
6638-100 |
Biovision |
each |
EUR 418.8 |
IL-10 Antibody |
6638-30T |
Biovision |
each |
EUR 175.2 |
IL-10 Antibody |
F51527-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
Description: The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. |
IL-10 Antibody |
F51527-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
Description: The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. |
His-IL-10 |
E13-019-1 |
EnoGene |
10μg |
EUR 193.2 |
His-IL-10 |
E13-019-2 |
EnoGene |
50μg |
EUR 606 |
IL-10 Antibody |
R30421 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Interleukin-10, also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse il10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32. |
Il-10 Antibody |
RQ6187 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNF-alpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse IL 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32. |
Il-10 Antibody |
RQ4389 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. [UniProt] |
IL-10 Antibody |
RQ4550 |
NSJ Bioreagents |
100ug |
EUR 356.15 |
Description: Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFNg, IL-2, IL-3, TNFa and GM-CSF made by cells such as macrophages and regulatory T-cells.IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al. (1992) showed that the mouse Il 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al. (1997) mapped the IL10 gene to the junction between 1q31 and 1q32. |
IL-10 Antibody |
V7295-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
IL-10 Antibody |
V7295-20UG |
NSJ Bioreagents |
20 ug |
EUR 153.3 |
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
IL-10 Antibody |
V7295IHC-7ML |
NSJ Bioreagents |
7 ml |
EUR 349.3 |
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
IL-10 Antibody |
V7295SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
Human Interleukin-10 (IL-10) Antibody |
13109-05011 |
AssayPro |
150 ug |
EUR 260.4 |
Recombinant Human Interleukin-10/IL-10 |
CX04-10ug |
Novoprotein |
10ug |
EUR 242.4 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Interleukin-10/IL-10 |
CX04-1mg |
Novoprotein |
1mg |
EUR 2983.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Interleukin-10/IL-10 |
CX04-500ug |
Novoprotein |
500ug |
EUR 2106 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Interleukin-10/IL-10 |
CX04-50ug |
Novoprotein |
50ug |
EUR 595.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Mouse Interleukin-10/IL-10 |
C697-10ug |
Novoprotein |
10ug |
EUR 242.4 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse Interleukin-10/IL-10 |
C697-1mg |
Novoprotein |
1mg |
EUR 2983.2 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse Interleukin-10/IL-10 |
C697-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse Interleukin-10/IL-10 |
C697-50ug |
Novoprotein |
50ug |
EUR 595.2 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
IL-10, Interleukin-10, murine (mouse) |
RC232-21 |
Bio Basic |
2ug |
EUR 125.26 |
|
Polyclonal IL-10 Antibody |
APR00338G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-10 . This antibody is tested and proven to work in the following applications: |
IL-10 Recombinant Protein |
40-253-0002mg |
ProSci |
0.002 mg |
EUR 311.1 |
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues. |
IL-10 Recombinant Protein |
40-253-001mg |
ProSci |
0.01 mg |
EUR 437.1 |
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues. |
IL-10 Recombinant Protein |
40-417-0002mg |
ProSci |
0.002 mg |
EUR 311.1 |
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues. |
IL-10 Recombinant Protein |
40-417-001mg |
ProSci |
0.01 mg |
EUR 437.1 |
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues. |
IL-10 Recombinant Protein |
40-471-0002mg |
ProSci |
0.002 mg |
EUR 311.1 |
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant rat IL-10 is an 18.7 kDa protein of 160 amino acid residues. |
IL-10 Recombinant Protein |
40-471-001mg |
ProSci |
0.01 mg |
EUR 437.1 |
Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant rat IL-10 is an 18.7 kDa protein of 160 amino acid residues. |
IL-10, human recombinant |
4155-1000 |
Biovision |
each |
EUR 6324 |
IL-10, human recombinant |
4155-50 |
Biovision |
each |
EUR 836.4 |
IL-10 Polyclonal Antibody |
41553-100ul |
SAB |
100ul |
EUR 302.4 |
IL-10 Polyclonal Antibody |
41553-50ul |
SAB |
50ul |
EUR 224.4 |
IL-10, murine recombinant |
4156-10 |
Biovision |
each |
EUR 294 |
IL-10, murine recombinant |
4156-1000 |
Biovision |
each |
EUR 6324 |
IL-10, murine recombinant |
4156-50 |
Biovision |
each |
EUR 836.4 |
IL-10, human recombinant |
4155-10 |
Biovision |
each |
EUR 294 |
IL-10, rat recombinant |
4157-10 |
Biovision |
each |
EUR 360 |
IL-10, rat recombinant |
4157-1000 |
Biovision |
each |
EUR 7810.8 |
IL-10 Blocking Peptide |
BF0175-BP |
Affbiotech |
1mg |
EUR 234 |
IL-10 Recombinant Protein |
91-582 |
ProSci |
0.05 mg |
EUR 821.4 |
Description: Mouse Il10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. Many viruses encode viral members of the IL-10 family, such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV).Its main function is inhibiting the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Although human and mouse IL-10 are 81% identical at the nucleotide and amino acid level, mouse IL-10 is species-specific and does not act on human cells. Interestingly, Human IL-10 is active on mouse cells. |
IL-10 Recombinant Protein |
91-880 |
ProSci |
0.05 mg |
EUR 821.4 |
Description: Interleukin 10(IL10), also known as cytokine synthesis inhibitory factor (CSIF),is a secreted protein and belongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokine that has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 in produced in several T helper populations, it is proposed that it provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viable biomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations |
IL-10 Recombinant Protein |
96-893 |
ProSci |
0.02 mg |
EUR 519 |
Description: Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body. |
IL-10 Recombinant Protein |
97-003 |
ProSci |
0.02 mg |
EUR 468.6 |
Description: Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body. |
IL-10 Recombinant Protein |
90-494 |
ProSci |
10 ug |
EUR 468.6 |
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. |
IL-10 Recombinant Protein |
90-495 |
ProSci |
50 ug |
EUR 651.3 |
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. |
IL-10 Recombinant Protein |
90-498 |
ProSci |
10 ug |
EUR 468.6 |
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. |
IL-10 Recombinant Protein |
90-499 |
ProSci |
50 ug |
EUR 1023 |
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. |
IL-10 Recombinant Protein |
90-555 |
ProSci |
10 ug |
EUR 500.1 |
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. |
IL-10 Polyclonal Antibody |
ABP52869-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of IL-10 from Human. This IL-10 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-10 |
IL-10 Polyclonal Antibody |
ABP52869-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of IL-10 from Human. This IL-10 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-10 |
IL-10 Polyclonal Antibody |
ABP52869-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of IL-10 from Human. This IL-10 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IL-10 |
IL-10 Polyclonal Antibody |
ES3868-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against IL-10 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
IL-10 Polyclonal Antibody |
ES3868-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against IL-10 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
anti- IL-10 antibody |
FNab04211 |
FN Test |
100µg |
EUR 702 |
|
Description: Antibody raised against IL-10 |
anti- IL-10 antibody |
FNab04212 |
FN Test |
100µg |
EUR 702 |
|
Description: Antibody raised against IL-10 |
anti-IL-10 (3C12C12) |
LF-MA30009 |
Abfrontier |
100 ul |
EUR 448.8 |
Description: Mouse Monoclonal to IL-10 |
Recombinant Hamster IL-10 |
P0539 |
FN Test |
100ug |
EUR 626.83 |
|
Description: Recombinant Hamster protein for IL-10 |
IL-10 R alpha |
GT15185 |
Neuromics |
100 ug |
EUR 631.2 |
rec IL-10 (murine) |
H-9715.0002 |
Bachem |
2.0µg |
EUR 194.4 |
rec IL-10 (murine) |
H-9715.0010 |
Bachem |
10.0µg |
EUR 457.2 |
Human IL-10 Antibody |
R30116 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor(CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells.IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse IL 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32. |
Mouse Il-10 Antibody |
R30117 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Interleukin-10, also known as human cytokine synthesis inhibitory factor(CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse IL 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32. |
Rat Il-10 Antibody |
R30118 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Interleukin-10 is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. |
Anti-IL-10 antibody |
STJ96503 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to IL-10. |
Anti-IL-10 antibody |
STJ98167 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to IL-10. |
Recombinant Human IL-10 |
HEILP-1001 |
Cyagen |
10ug |
Ask for price |
Recombinant Murine IL-10 |
MEILP-1001 |
Cyagen |
10ug |
Ask for price |
Recombinant Rat IL-10 |
REILP-1001 |
Cyagen |
10ug |
Ask for price |
Human Interleukin 10 (IL-10) CLIA Kit |
abx195842-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Mouse Interleukin 10 (IL-10) CLIA Kit |
abx195843-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Rat Interleukin 10 (IL-10) CLIA Kit |
abx195844-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Interleukin 10,IL-10 ELISA KIT |
201-12-0103 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Interleukin 10, IL-10 ELISA KIT |
CSB-E04593h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 10, IL-10 in samples from serum, urine, cell culture supernates, asciticfluid, cerebrospinalfluid (CSF), saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin 10, IL-10 ELISA KIT |
1-CSB-E04593h |
Cusabio |
-
EUR 723.60
-
EUR 5096.40
-
EUR 2712.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 10, IL-10 in samples from serum, urine, cell culture supernates, asciticfluid, cerebrospinalfluid(CSF), saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse interleukin 10, IL-10 ELISA KIT |
CSB-E04594m-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse interleukin 10, IL-10 ELISA KIT |
1-CSB-E04594m |
Cusabio |
-
EUR 723.60
-
EUR 5096.40
-
EUR 2712.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Interleukin 10, IL-10 ELISA KIT |
CSB-E04595r-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Interleukin 10, IL-10 ELISA KIT |
1-CSB-E04595r |
Cusabio |
-
EUR 723.60
-
EUR 5096.40
-
EUR 2712.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 10, IL-10 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Chicken Interleukin 10 (IL-10) ELISA Kit |
DEIABL-CK3 |
Creative Diagnostics |
96T |
EUR 752.4 |
Description: This CD Interleukin 10 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human IL-10. This ELISA kit for research use only, not for therapeutic or diagnostic applications! |
Goat Interleukin 10, IL-10 ELISA Kit |
CSB-E09809g-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Goat Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Goat Interleukin 10, IL-10 ELISA Kit |
1-CSB-E09809g |
Cusabio |
-
EUR 813.60
-
EUR 5572.80
-
EUR 2960.40
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Goat Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Goat Interleukin 10,IL-10 ELISA Kit |
CN-00369S1 |
ChemNorm |
96T |
EUR 529.2 |
Rabbit Interleukin 10,IL-10 ELISA Kit |
CN-00727R1 |
ChemNorm |
96T |
EUR 529.2 |
Rabbit Interleukin 10,IL-10 ELISA Kit |
CN-00727R2 |
ChemNorm |
48T |
EUR 349.2 |
Mouse interleukin 10,IL-10 ELISA KIT |
CN-02459M1 |
ChemNorm |
96T |
EUR 536.4 |
Mouse interleukin 10,IL-10 ELISA KIT |
CN-02459M2 |
ChemNorm |
48T |
EUR 355.2 |
Human Interleukin 10,IL-10 ELISA KIT |
CN-03221H1 |
ChemNorm |
96T |
EUR 520.8 |
Human Interleukin 10,IL-10 ELISA KIT |
CN-03221H2 |
ChemNorm |
48T |
EUR 340.8 |
PoFAine interleukin 10,IL-10 ELISA Kit |
CN-01259P1 |
ChemNorm |
96T |
EUR 564 |
PoFAine interleukin 10,IL-10 ELISA Kit |
CN-01259P2 |
ChemNorm |
48T |
EUR 384 |
Rat Interleukin 10,IL-10 ELISA KIT |
CN-01602R1 |
ChemNorm |
96T |
EUR 542.4 |
Rat Interleukin 10,IL-10 ELISA KIT |
CN-01602R2 |
ChemNorm |
48T |
EUR 362.4 |
Pig interleukin 10, IL-10 ELISA Kit |
CSB-E06779p-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Pig interleukin 10, IL-10 ELISA Kit |
1-CSB-E06779p |
Cusabio |
-
EUR 752.40
-
EUR 5336.40
-
EUR 2836.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rabbit Interleukin 10, IL-10 ELISA Kit |
CSB-E06897Rb-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rabbit Interleukin 10, IL-10 ELISA Kit |
1-CSB-E06897Rb |
Cusabio |
-
EUR 723.60
-
EUR 5096.40
-
EUR 2712.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Sheep Interleukin 10, IL-10 ELISA Kit |
CSB-E12817Sh-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativecompetitive ELISA kit for measuring Sheep Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Sheep Interleukin 10, IL-10 ELISA Kit |
1-CSB-E12817Sh |
Cusabio |
-
EUR 1135.20
-
EUR 6938.40
-
EUR 3672.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Sheep Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Chicken Interleukin 10, IL-10 ELISA Kit |
CSB-E12835C-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Chicken Interleukin 10, IL-10 ELISA Kit |
1-CSB-E12835C |
Cusabio |
-
EUR 1053.60
-
EUR 6570.00
-
EUR 3480.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Bovine Interleukin 10, IL-10 ELISA Kit |
CSB-E12917B-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Bovine Interleukin 10, IL-10 ELISA Kit |
1-CSB-E12917B |
Cusabio |
-
EUR 867.60
-
EUR 5859.60
-
EUR 3109.20
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Dog Interleukin 10, IL-10 ELISA Kit |
CSB-E11261c-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Dog Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Dog Interleukin 10, IL-10 ELISA Kit |
1-CSB-E11261c |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
-
EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Dog Interleukin 10, IL-10 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Porcine IL-10(Interleukin-10) ELISA Kit |
EP0086 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 18.75pg/ml |
Monkey IL-10(Interleukin-10) ELISA Kit |
EMK0036 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 9.375pg/ml |
Rat IL-10(Interleukin-10) ELISA Kit |
ER0033 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml |
Rabbit IL-10(Interleukin-10) ELISA Kit |
ERB0056 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml |
Sheep IL-10(Interleukin-10) ELISA Kit |
ESH0009 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 9.375pg/ml |
Human Interleukin-10 (IL-10) ELISA Kit |
LF-EK60026 |
Abfrontier |
1×96T |
EUR 948 |
IL-10 Interleukin-10 Mouse Recombinant Protein |
PROTP18893 |
BosterBio |
Regular: 10ug |
EUR 380.4 |
Description: IL-10 Recombinant Mouse produced in E.coli is a single, non-glycosylated polypeptide chain containing 161 amino acids and having a molecular mass of 18785 Dalton. ;The Interleukin-10 Mouse is purified by proprietary chromatographic techniques. |
IL-10 Interleukin-10 Human Recombinant Protein |
PROTP22301-2 |
BosterBio |
Regular: 10ug |
EUR 380.4 |
Description: Interleukin-10 Human Recombinant produced in E.coli is a single non-glycosylated polypeptide chains containing 161 amino acids each and having a molecular mass of 18.6kDa.;The IL-10 is purified by proprietary chromatographic techniques. |
IL-10 Interleukin-10 Rat Recombinant Protein |
PROTP29456 |
BosterBio |
Regular: 10ug |
EUR 380.4 |
Description: IL-10 Recombinant Rat produced in E.coli is a single, glycosylated polypeptide chain containing 160 amino acids and having a molecular mass of 18.6 kDa. ;The Interleukin-10 Mouse is purified by proprietary chromatographic techniques. |
Mouse interleukin 10(IL-10)ELISA Kit |
GA-E0044MS-48T |
GenAsia Biotech |
48T |
EUR 403.2 |
Mouse interleukin 10(IL-10)ELISA Kit |
GA-E0044MS-96T |
GenAsia Biotech |
96T |
EUR 640.8 |
Rabbit Interleukin 10,IL-10 ELISA Kit |
GA-E0111RB-48T |
GenAsia Biotech |
48T |
EUR 391.2 |
Rabbit Interleukin 10,IL-10 ELISA Kit |
GA-E0111RB-96T |
GenAsia Biotech |
96T |
EUR 628.8 |
DCS is distinguished from monocytes exposed anti-CD25 during maturation, anti-CD25 treatment affects the ability of human DCS to induce CD4 + cell proliferation in responding to alloantigens, maintaining endocytic, anti-CD25 treated capacity to produce low level IL-12 and IFN and high levels of IL-10. All these characteristics show that DC can be used in cellular therapy both to induce allograft tolerance (anti-CD25 treated DCS) or to restore immunity to tumors (IL-2 DCRE).