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Learn at the synthesis of complement components by human kidney mesangial cells in culture. Assessment of cytokine effects.
Learn at the synthesis of complement components by human kidney mesangial cells in culture. Assessment of cytokine effects.
Posted by Frank

Cultivation of kidney mesangial cells (MC) is easily established and widely used. MCs produce several complementary regulatory proteins (C). We studied whether MC synthesized components C (C3, C5, C8). MC culture was established from the normal portion of nephrectomy for kidney cancer. After growing to a close meeting in RPMI / 17% FBS and resting 24 hours in RPMI / 0.5% FBS, MC stimulated up to 72 hours with IL-1β or IL-6 (10, 100, 1000 U / mL).

Both C5 and C8 detection by ELISA. While C3 is present in supernatant in basal conditions (15.5-107.6 ng / 10 (6) cells / 24 hours) in different MC lines. IL-1β regulates synthesis with 2.4-4.5 folds, while IL-6 does not show any effect. The c3 synthetic rate is cell 1.76 ng / 10 (6) under IL-1 stimulation versus basal level 0.37 ng / hour / 10 (6) cells. MC C3 production, especially induced by IL-1 may have pathogenetic relevance in glomerulonephritis.

Rooperol, cytokine synthesis inhibitors, reduces breathing explosions on leukocytes and human macrophies and mice.

Chemiluminescence enhanced by Luminol is measured in all fresh human blood, or human neutrophils are isolated from the blood of heparation, macrophages of alveolar humans and macrophages of alveolar rats which are stimulated with endotoxin bacteria (LPS). Esther TetraAceTate from Rooperol, a recatechol that shows anticoytokine activity, added to the cell simultaneously with LPS inhibiting the breathing explosion. The effective concentration of Rooperol is in the range of 1-10 mothers depending on the type of cell and in accordance with the inhibition of the production of nitrate oxide by macrophages of mice alveolar. Thus Roerol can reduce some effects of excessive phagocytic activity and inflammatory reactions but by extinguishing free radical production can also reduce resistance to bacterial infections.

Leptin increases survival and induces migration, degranulation, and synthesis of cytokines from human basophyl.

Basophils are the rarest leukocytes in human blood, but are now recognized as one of the most important immunomodulatory cells and the effector in allergic inflammation. Leptin, a member of the Cytokine IL-6 family, has a metabolic effect as an adipocine, and is also known to participate in the pathogenesis of inflammatory reactions. Because there is an epidemiological relationship between obesity and allergies, we examine whether the basophyl function is modified by leptin.

We found that the human basophyl expressed Leptin receptor (LEPR) at MRNA and surface protein levels, which was regulated by IL-33. Leptin exerts strong effects on several basophyl functions. This causes a strong migration response to human basophyl, potentially similar to the basophil-active kemokine. Also, Leptin increases the survival of human basophyl, even though its potential is less than IL-3. In addition, CD63, the marker of basophil activation is stated on the cell surface, regulated by leptin, the effect is neutralized by blocking LEPR.

Basophyl degranulation assessment and cytokine synthesis found that leptin shows a strong priming effect on human basophyl degranulation in response to FCεRI aggregation and induces Th2, but not the production of cytokines by cells. In short, these findings indicate that leptin may be the main molecule that mediates the effects of adipocytes in inflammatory cells such as basophiles by binding LEPR and activating cellular functions, which may worsen allergic inflammation.

Learn at the synthesis of complement components by human kidney mesangial cells in culture. Assessment of cytokine effects.

Cultivation of kidney mesangial cells (MC) is easily established and widely used. MCs produce several complementary regulatory proteins (C). We studied whether MC synthesized components C (C3, C5, C8). MC culture was established from the normal portion of nephrectomy for kidney cancer. After growing to a close meeting in RPMI / 17% FBS and resting 24 hours in RPMI / 0.5% FBS, MC stimulated up to 72 hours with IL-1β or IL-6 (10, 100, 1000 U / mL). Both C5 and C8 detection by ELISA.

While C3 is present in supernatant in basal conditions (15.5-107.6 ng / 10 (6) cells / 24 hours) in different MC lines. IL-1β regulates synthesis with 2.4-4.5 folds, while IL-6 does not show any effect. The c3 synthetic rate is cell 1.76 ng / 10 (6) under IL-1 stimulation versus basal level 0.37 ng / hour / 10 (6) cells. MC C3 production, especially induced by IL-1 may have pathogenetic relevance in glomerulonephritis.

Rooperol, cytokine synthesis inhibitors, reduces breathing explosions on leukocytes and human macrophies and mice.

Chemiluminescence enhanced by Luminol is measured in all fresh human blood, or human neutrophils are isolated from the blood of heparation, macrophages of alveolar humans and macrophages of alveolar rats which are stimulated with endotoxin bacteria (LPS). Esther TetraAceTate from Rooperol, a recatechol that shows anticoytokine activity, added to the cell simultaneously with LPS inhibiting the breathing explosion. The effective concentration of Rooperol is in the range of 1-10 mothers depending on the type of cell and in accordance with the inhibition of the production of nitrate oxide by macrophages of mice alveolar. Thus Roerol can reduce some effects of excessive phagocytic activity and inflammatory reactions but by extinguishing free radical production can also reduce resistance to bacterial infections.

Learn at the synthesis of complement components by human kidney mesangial cells in culture. Assessment of cytokine effects.

Leptin increases survival and induces migration, degranulation, and synthesis of cytokines from human basophyl.

Basophils are the rarest leukocytes in human blood, but are now recognized as one of the most important immunomodulatory cells and the effector in allergic inflammation. Leptin, a member of the Cytokine IL-6 family, has a metabolic effect as an adipocine, and is also known to participate in the pathogenesis of inflammatory reactions. Because there is an epidemiological relationship between obesity and allergies, we examine whether the basophyl function is modified by leptin. We found that the human basophyl expressed Leptin receptor (LEPR) at MRNA and surface protein levels, which was regulated by IL-33.

Leptin exerts strong effects on several basophyl functions. This causes a strong migration response to human basophyl, potentially similar to the basophil-active kemokine. Also, Leptin increases the survival of human basophyl, even though its potential is less than IL-3. In addition, CD63, the marker of basophil activation is stated on the cell surface, regulated by leptin, the effect is neutralized by blocking LEPR. Basophyl degranulation assessment and cytokine synthesis found that leptin shows a strong priming effect on human basophyl degranulation in response to FCεRI aggregation and induces Th2, but not the production of cytokines by cells.

TWEAK, recombinant / TNFSF12, recombinant (Human)
054-85 10 μg
EUR 261.36

Recombinant Human PGⅡ
E21-RA29-1 - Ask for price

Recombinant Human GC
MBS7616369-005mg 0.05mg
EUR 405

Recombinant Human GC
MBS7616369-02mg 0.2mg
EUR 760

Recombinant Human GC
MBS7616369-1mg 1mg
EUR 2175

Recombinant Human GC
MBS7616369-5x1mg 5x1mg
EUR 8410

Recombinant Human GH
MBS7608417-005mg 0.05mg
EUR 405

Recombinant Human GH
MBS7608417-02mg 0.2mg
EUR 760

Recombinant Human GH
MBS7608417-1mg 1mg
EUR 2175

Recombinant Human GH
MBS7608417-5x1mg 5x1mg
EUR 8410

Recombinant Human GS
MBS7608504-005mg 0.05mg
EUR 345

Recombinant Human GS
MBS7608504-02mg 0.2mg
EUR 635

Recombinant Human GS
MBS7608504-1mg 1mg
EUR 1800

Recombinant Human GS
MBS7608504-5x1mg 5x1mg
EUR 6955

Recombinant Human C6
MBS7608602-005mg 0.05mg
EUR 345

Recombinant Human C6
MBS7608602-02mg 0.2mg
EUR 635

Recombinant Human C6
MBS7608602-1mg 1mg
EUR 1800

Recombinant Human C6
MBS7608602-5x1mg 5x1mg
EUR 6955

Recombinant Human AR
MBS7612815-005mg 0.05mg
EUR 405

Recombinant Human AR
MBS7612815-02mg 0.2mg
EUR 760

Recombinant Human AR
MBS7612815-1mg 1mg
EUR 2175

Recombinant Human FH
MBS7613325-005mg 0.05mg
EUR 405

Recombinant Human FH
MBS7613325-02mg 0.2mg
EUR 760

Recombinant Human FH
MBS7613325-1mg 1mg
EUR 2175

Recombinant Human FH
MBS7613325-5x1mg 5x1mg
EUR 8410

Recombinant Human HP
MBS7614251-005mg 0.05mg
EUR 405

Recombinant Human HP
MBS7614251-02mg 0.2mg
EUR 760

Recombinant Human HP
MBS7614251-1mg 1mg
EUR 2175

Recombinant Human HP
MBS7614251-5x1mg 5x1mg
EUR 8410

Recombinant Human AR
MBS7612815-5x1mg 5x1mg
EUR 8410

Recombinant Human CP
MBS7613562-005mg 0.05mg
EUR 405

Recombinant Human CP
MBS7613562-02mg 0.2mg
EUR 760

Recombinant Human CP
MBS7613562-1mg 1mg
EUR 2175

Recombinant Human CP
MBS7613562-5x1mg 5x1mg
EUR 8410

Recombinant Human TH
MBS7613924-005mg 0.05mg
EUR 345

Recombinant Human TH
MBS7613924-02mg 0.2mg
EUR 635

Recombinant Human TH
MBS7613924-1mg 1mg
EUR 1800

Recombinant Human TH
MBS7613924-5x1mg 5x1mg
EUR 6955

Recombinant Human C5
MBS7609068-005mg 0.05mg
EUR 345

Recombinant Human C5
MBS7609068-02mg 0.2mg
EUR 635

Recombinant Human C5
MBS7609068-1mg 1mg
EUR 1800

Recombinant Human C5
MBS7609068-5x1mg 5x1mg
EUR 6955

Recombinant Human Rb
MBS7609212-005mg 0.05mg
EUR 470

Recombinant Human Rb
MBS7609212-02mg 0.2mg
EUR 885

Recombinant Human Rb
MBS7609212-1mg 1mg
EUR 2540

Recombinant Human Rb
MBS7609212-5x1mg 5x1mg
EUR 9820

Recombinant Human FH
MBS7609262-005mg 0.05mg
EUR 560

Recombinant Human FH
MBS7609262-02mg 0.2mg
EUR 1060

Recombinant Human FH
MBS7609262-1mg 1mg
EUR 3065

Recombinant Human FH
MBS7609262-5x1mg 5x1mg
EUR 11850

Recombinant Human C4
MBS7609327-005mg 0.05mg
EUR 405

Recombinant Human C4
MBS7609327-02mg 0.2mg
EUR 760

Recombinant Human C4
MBS7609327-1mg 1mg
EUR 2175

Recombinant Human C4
MBS7609327-5x1mg 5x1mg
EUR 8410

Recombinant Human C4
MBS7609328-005mg 0.05mg
EUR 405

Recombinant Human C4
MBS7609328-02mg 0.2mg
EUR 760

Recombinant Human C4
MBS7609328-1mg 1mg
EUR 2175

Recombinant Human C4
MBS7609328-5x1mg 5x1mg
EUR 8410

Recombinant Human GH
P1223-.1 10X10ug
EUR 240
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human GH
P1223-.5 50X10ug
EUR 538.4
Description: Peptides & Proteins|Recombinant Proteins

DR3 (human):Fc (human), (recombinant)
MBS566215-005mg 0.05mg
EUR 585

DR3 (human):Fc (human), (recombinant)
MBS566215-5x005mg 5x0.05mg
EUR 2585

Recombinant Human REC8
MBS7613173-005mg 0.05mg
EUR 405

Recombinant Human REC8
MBS7613173-02mg 0.2mg
EUR 760

Recombinant Human REC8
MBS7613173-1mg 1mg
EUR 2175

Recombinant Human REC8
MBS7613173-5x1mg 5x1mg
EUR 8410

Recombinant Human PRL
AP76222 1mg
EUR 2369

Recombinant Human PRL
CM10-10ug 10ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human PRL
CM10-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human PRL
CM10-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human PRL
CM10-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Human BAD
7-04501 2µg Ask for price

Recombinant Human BAD
7-04502 5µg Ask for price

Recombinant Human BAD
7-04503 10µg Ask for price

Recombinant Human CD2
7-04717 2µg Ask for price

Recombinant Human CD2
7-04718 5µg Ask for price

Recombinant Human CD2
7-04719 10µg Ask for price

Recombinant Human CD9
7-04741 2µg Ask for price

Recombinant Human CD9
7-04742 5µg Ask for price

Recombinant Human CD9
7-04743 10µg Ask for price

Recombinant Human p53
7-05785 2µg Ask for price

Recombinant Human p53
7-05786 5µg Ask for price

Recombinant Human p53
7-05787 10µg Ask for price

Recombinant Human CSK
Z500098 10 µg
EUR 370
Description: CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus . A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells . This association is highly specific and it is speculated that PEP may be an effector and/or regulator of CSK in T cells and other hemopoietic cells.

Recombinant Human BMX
Z500413 10 µg
EUR 370
Description: Recombinant full-length human BMX was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX is found to induce activation of the Stat signalling pathway.

Recombinant Human EGF
Z100139 1.0 mg
EUR 205
Description: Epidermal growth factor (EGF) is a small mitogenic protein that is thought to be involved in mechanisms such as normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and functional homology with human type-alpha transforming growth factor (hTGF alpha), which is a competitor for EGF receptor sites. EGF receptors are expressed in almost all types of tissues. Parietal endoderm, mature skeletal muscles, and hematopoietic tissues do not express the receptor. The EGF receptor, designated HER1, is a 170 kDa transmembrane glycoprotein with a length of 1186 amino acids. It is identical with a previously described glycoprotein called SA-7 (species antigen 7). The extracellular receptor domain has a length of 621 amino acids, including 11 glycosylated asparagine residues and 51 cysteine residues. This domain contains the EGF binding site and also binds mammalian TGF-alpha.

Recombinant Human GH1
Z100265 500 µg
EUR 85
Description: The physiological activity for which growth hormone is best known is the promotion of growth of bone, cartilage, and soft tissues. Detectable levels of growth hormone are found throughout the remainder of adulthood, suggesting other functions in addition to promotion of growth. Growth hormone may be important for the maintenance of lean body mass; most growth-promoting effects of growth hormone are mediated by IGF-1 the synthesis of which is regulated by growth hormone. The biological activities of growth hormone are mediated by receptors belonging to one of the cytokine receptor families. Growth hormone has been shown to be produced by T cells, B cells, and macrophages. In human lymphocytes growth hormone appears to up-regulate its own expression. Growth hormone appears to act as an enhancer of immune responses and is produced in considerable amounts by T helper cells.

Recombinant Human GH1
Z100269 1.0 mg
EUR 150
Description: The physiological activity for which growth hormone is best known is the promotion of growth of bone, cartilage, and soft tissues. Detectable levels of growth hormone are found throughout the remainder of adulthood, suggesting other functions in addition to promotion of growth. Growth hormone may be important for the maintenance of lean body mass; most growth-promoting effects of growth hormone are mediated by IGF-1 the synthesis of which is regulated by growth hormone. The biological activities of growth hormone are mediated by receptors belonging to one of the cytokine receptor families. Growth hormone has been shown to be produced by T cells, B cells, and macrophages. In human lymphocytes growth hormone appears to up-regulate its own expression. Growth hormone appears to act as an enhancer of immune responses and is produced in considerable amounts by T helper cells.

Recombinant Human IL2
Z100485 50 µg
EUR 85
Description: A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.

Recombinant Human IL2
Z100487 100 µg
EUR 145
Description: A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.

Recombinant Human IL2
Z100489 1.0 mg
EUR 615
Description: A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.

Recombinant Human IL3
Z100515 10 µg
EUR 85
Description: IL3 is produced mainly by T cells following cell activation by antigens and mitogens, but also by keratinocytes, natural killer cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not required for activity. IL3 sequences are evolutionarily less well conserved with human and murine IL3 sharing approximately 29% homology (at the protein level) and murine and rat IL3 sharing approximately 54% homology. IL3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells and various myeloid leukemia cells. Binding of IL3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein. Recombinant human IL3 is a non-glycosylated globular protein.

Recombinant Human IL3
Z100517 50 µg
EUR 155
Description: IL3 is produced mainly by T cells following cell activation by antigens and mitogens, but also by keratinocytes, natural killer cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not required for activity. IL3 sequences are evolutionarily less well conserved with human and murine IL3 sharing approximately 29% homology (at the protein level) and murine and rat IL3 sharing approximately 54% homology. IL3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells and various myeloid leukemia cells. Binding of IL3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein. Recombinant human IL3 is a non-glycosylated globular protein.

Recombinant Human IL3
Z100519 1.0 mg
EUR 2260
Description: IL3 is produced mainly by T cells following cell activation by antigens and mitogens, but also by keratinocytes, natural killer cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not required for activity. IL3 sequences are evolutionarily less well conserved with human and murine IL3 sharing approximately 29% homology (at the protein level) and murine and rat IL3 sharing approximately 54% homology. IL3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells and various myeloid leukemia cells. Binding of IL3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein. Recombinant human IL3 is a non-glycosylated globular protein.

Recombinant Human IL4
Z100545 10 µg
EUR 60
Description: IL4 is produced mainly by a sub-population of activated T helper cells which also secrete IL5 and IL6. The biological activities of IL4 are mediated by a specific receptor, the extracellular domain of which is related to the receptors for EPO, IL6, and the beta chain of the IL-2 receptor. IL4 participates in several B-cell activation processes as well as of other cell types. A co-stimulator of DNA-synthesis, IL4 induces the expression of class II MHC molecules on resting B-cells, enhances both secretion and cell surface expression of IgE and IgG1, and also regulates the expression of the low affinity Fc receptor for IgE on both lymphocytes and monocytes. Pre-treatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.

Recombinant Human IL4
Z100547 100 µg
EUR 470
Description: IL4 is produced mainly by a sub-population of activated T helper cells which also secrete IL5 and IL6. The biological activities of IL4 are mediated by a specific receptor, the extracellular domain of which is related to the receptors for EPO, IL6, and the beta chain of the IL-2 receptor. IL4 participates in several B-cell activation processes as well as of other cell types. A co-stimulator of DNA-synthesis, IL4 induces the expression of class II MHC molecules on resting B-cells, enhances both secretion and cell surface expression of IgE and IgG1, and also regulates the expression of the low affinity Fc receptor for IgE on both lymphocytes and monocytes. Pre-treatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.

Recombinant Human IL4
Z100549 1.0 mg
EUR 3450
Description: IL4 is produced mainly by a sub-population of activated T helper cells which also secrete IL5 and IL6. The biological activities of IL4 are mediated by a specific receptor, the extracellular domain of which is related to the receptors for EPO, IL6, and the beta chain of the IL-2 receptor. IL4 participates in several B-cell activation processes as well as of other cell types. A co-stimulator of DNA-synthesis, IL4 induces the expression of class II MHC molecules on resting B-cells, enhances both secretion and cell surface expression of IgE and IgG1, and also regulates the expression of the low affinity Fc receptor for IgE on both lymphocytes and monocytes. Pre-treatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.

Recombinant Human IL6
Z100555 20 µg
EUR 235
Description: IL6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL6 which is inactive on human cells, both human and murine IL6 are equally active on murine cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL6 is a 21 kDa, non-glycosylated protein that contains two disulfide bridges.

Recombinant Human IL6
Z100557 100 µg
EUR 960
Description: IL6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL6 which is inactive on human cells, both human and murine IL6 are equally active on murine cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL6 is a 21 kDa, non-glycosylated protein that contains two disulfide bridges.

Recombinant Human IL6
Z100559 10 x 100 µg (Z100557 x 10)
EUR 4215
Description: IL6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL6 which is inactive on human cells, both human and murine IL6 are equally active on murine cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL6 is a 21 kDa, non-glycosylated protein that contains two disulfide bridges.

Recombinant Human LIF
Z100605 10 µg
EUR 85
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Human LIF
Z100607 100 µg
EUR 360
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Human LIF
Z100609 1.0 mg
EUR 1500
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Human OSM
Z100755 10 µg
EUR 85
Description: Oncostatin M is produced by monocytes and T cells after cell activation, adherent macrophages, and various T cell lines. Oncostatin M is a member of the IL-6-related cytokine subfamily that includes IL-6, IL-11, LIF, CNTF and CT-1. Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines. When gp130 dimerizes with LIF receptor beta subunit this generates the high affinity type 1 OSM receptor. When gp130 dimerizes with a protein known as OSM receptor beta this generates the type 2 OSM receptor. Both OSM receptors activate the receptor-associated Janus kinases JAK1, JAK2, and TYK2. Signaling also involves the transcriptional activators STAT3 and STAT5b (see also: STAT proteins) were specifically activated through the gp130-OSM-R-beta type II heterocomplex. The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. Oncostatin M inhibits the growth of several tumor cell lines (A375 melanoma, lung carcinomas). The antiproliferative activity of oncostatin M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular smooth muscle cells, and some normal cell lines. Oncostatin can inhibit the proliferation of murine M1 myeloid leukemic cells and induces their differentiation into macrophage-like cells, a function shared by LIF, G- CSF, and IL-6.

Recombinant Human OSM
Z100757 200 µg
EUR 925
Description: Oncostatin M is produced by monocytes and T cells after cell activation, adherent macrophages, and various T cell lines. Oncostatin M is a member of the IL-6-related cytokine subfamily that includes IL-6, IL-11, LIF, CNTF and CT-1. Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines. When gp130 dimerizes with LIF receptor beta subunit this generates the high affinity type 1 OSM receptor. When gp130 dimerizes with a protein known as OSM receptor beta this generates the type 2 OSM receptor. Both OSM receptors activate the receptor-associated Janus kinases JAK1, JAK2, and TYK2. Signaling also involves the transcriptional activators STAT3 and STAT5b (see also: STAT proteins) were specifically activated through the gp130-OSM-R-beta type II heterocomplex. The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. Oncostatin M inhibits the growth of several tumor cell lines (A375 melanoma, lung carcinomas). The antiproliferative activity of oncostatin M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular smooth muscle cells, and some normal cell lines. Oncostatin can inhibit the proliferation of murine M1 myeloid leukemic cells and induces their differentiation into macrophage-like cells, a function shared by LIF, G- CSF, and IL-6.

Recombinant Human OSM
Z100759 1.0 mg
EUR 2015
Description: Oncostatin M is produced by monocytes and T cells after cell activation, adherent macrophages, and various T cell lines. Oncostatin M is a member of the IL-6-related cytokine subfamily that includes IL-6, IL-11, LIF, CNTF and CT-1. Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines. When gp130 dimerizes with LIF receptor beta subunit this generates the high affinity type 1 OSM receptor. When gp130 dimerizes with a protein known as OSM receptor beta this generates the type 2 OSM receptor. Both OSM receptors activate the receptor-associated Janus kinases JAK1, JAK2, and TYK2. Signaling also involves the transcriptional activators STAT3 and STAT5b (see also: STAT proteins) were specifically activated through the gp130-OSM-R-beta type II heterocomplex. The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. Oncostatin M inhibits the growth of several tumor cell lines (A375 melanoma, lung carcinomas). The antiproliferative activity of oncostatin M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular smooth muscle cells, and some normal cell lines. Oncostatin can inhibit the proliferation of murine M1 myeloid leukemic cells and induces their differentiation into macrophage-like cells, a function shared by LIF, G- CSF, and IL-6.

Recombinant Human PTH
Z100775 100 µg
EUR 85
Description: Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

Recombinant Human PTH
Z100777 1.0 mg
EUR 705
Description: Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

Recombinant Human PTH
Z100779 2.0 mg
EUR 1140
Description: Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

Recombinant Human SCF
Z100815 10 µg
EUR 115
Description: SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotent stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when co-stimulated with other cytokines. The receptor for SCF, designated SCFR (CD117) is the oncogene designated as KIT. The biological activities of SCF are considerably synergised by colony stimulating factors; GM-CSF and G-CSF, and by IL7, EPO and some other growth and differentiation factors. In combination with IL7, SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells expressing the kit receptor. Recombinant Human SCF is a monomeric protein that contains intra-chain disulfide bonds.

Recombinant Human SCF
Z100817 100 µg
EUR 480
Description: SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotent stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when co-stimulated with other cytokines. The receptor for SCF, designated SCFR (CD117) is the oncogene designated as KIT. The biological activities of SCF are considerably synergised by colony stimulating factors; GM-CSF and G-CSF, and by IL7, EPO and some other growth and differentiation factors. In combination with IL7, SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells expressing the kit receptor. Recombinant Human SCF is a monomeric protein that contains intra-chain disulfide bonds.

Recombinant Human SCF
Z100819 10 x 100 µg (Z100817 x 10)
EUR 2350
Description: SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotential stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when it co-stimulates with other cytokines. The receptor for SCF, designated SCFR(CD117), is the oncogene designated as KIT. The biological activities of SCF are synergised considerably by colony stimulating factors GM-CSF and G-CSF, and also by IL-7, Epo and some other growth and differentiation factors. In combination with IL-7, SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells (see also: Chemotaxis), for example, mast cells expressing the kit receptor. One response to SCF in these cells is a characteristic rearrangement of the actin filaments of the cytoskeleton.

Recombinant Human TNF
Z100855 50 µg
EUR 85
Description: Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides although cells expressing CD8(+) secrete little or no TNF-alpha. In addition, TNF is secreted by peripheral neutrophilic granulocytes and by a number of transformed cell lines that include those of astrocytes, microglial cells, smooth muscle cells and fibroblasts. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and platelet activating factor. TNF-alpha shares approximately 30% homology with TNF-beta. Human TNF-alpha is a non-glycosylated protein of 17.6 kDa.

Recombinant Human TNF
Z100857 100 µg
EUR 135
Description: Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides although cells expressing CD8(+) secrete little or no TNF-alpha. In addition, TNF is secreted by peripheral neutrophilic granulocytes and by a number of transformed cell lines that include those of astrocytes, microglial cells, smooth muscle cells and fibroblasts. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and platelet activating factor. TNF-alpha shares approximately 30% homology with TNF-beta. Human TNF-alpha is a non-glycosylated protein of 17.6 kDa.

Recombinant Human TNF
Z100859 1.0 mg
EUR 630
Description: Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and PAF (platelet activating factor). Human TNF-alpha is a non-glycosylated protein of 17 kDa and a length of 157 amino acids. Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%. TNF-alpha forms dimers and trimers.

Recombinant Human LTA
Z100865 20 µg
EUR 85
Description: TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.

Recombinant Human LTA
Z100867 100 µg
EUR 345
Description: TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.

Recombinant Human LTA
Z100869 1.0 mg
EUR 1500
Description: TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.

Recombinant Human MIF
Z100915 25 µg
EUR 75
Description: Macrophage Migration Inhibitory Factor (MIF) is a proinflammatory cytokine. MIF is involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Recombinant Human MIF
Z100917 100 µg
EUR 255
Description: Macrophage Migration Inhibitory Factor (MIF) is a proinflammatory cytokine. MIF is involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Recombinant Human MIF
Z100919 1.0 mg
EUR 1150
Description: Macrophage Migration Inhibitory Factor (MIF) is a proinflammatory cytokine. MIF is involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Recombinant Human IL7
Z100975 10 µg
EUR 85
Description: IL7 is a secreted cytokine of the hemopoietin family that primarily affects early B and T cells and plays an important role in stimulating the proliferation of lymphoid progenitors. IL7 is produced by stromal epithelial cells of the thymus, bone marrow, and intestines. Human and murine IL7 share 60% sequence homology at the primary level and known to exhibit cross species activity. Designated CD127, the human IL7 receptor is a strongly glycosylated membrane protein of 76 kDa. Recombinant Human IL7 is a 17.7 kDa, non-glycosylated protein.

Recombinant Human IL7
Z100977 100 µg
EUR 470
Description: IL7 is a secreted cytokine of the hemopoietin family that primarily affects early B and T cells and plays an important role in stimulating the proliferation of lymphoid progenitors. IL7 is produced by stromal epithelial cells of the thymus, bone marrow, and intestines. Human and murine IL7 share 60% sequence homology at the primary level and known to exhibit cross species activity. Designated CD127, the human IL7 receptor is a strongly glycosylated membrane protein of 76 kDa. Recombinant Human IL7 is a 17.7 kDa, non-glycosylated protein.

Recombinant Human IL7
Z100979 1.0 mg
EUR 6900
Description: IL7 is secreted constitutively into the conditioned medium of adherent bone marrow stromal cells and thymic cells. Mouse and human keratinocytes have been shown also to express and secrete IL7.Human (152 amino acids; 17.4 kDa) and murine IL7 (129 amino acids) show 60 % sequence homology at the protein level. The human IL7 receptor is an integral strongly glycosylated membrane proteins of 76 kDa expressed on activated T-cells. This receptor has been designated as CD127. IL7 receptors are expressed on pre-B-cells and their progenitors. They are not expressed on mature B-cells. IL7 receptors are expressed also on bone marrow macrophages. Functional IL7 receptors are found on the cell surface of multiphenotypic, biphenotypic, and immature lymphoid progenitors of B- cells with the gene arrangement of the heavy immunoglobulin chain such as those observed in the germ line

Recombinant Human IL2
Z101235 50 µg
EUR 235
Description: IL-2 is produced mainly by T cells expressing the surface antigen CD4 following cell activation by mitogens or allogen. Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T cell proliferation. Th1 and Th2 effector T cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas- mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.

Recombinant Human TNF
Z101385 50 µg
EUR 510
Description: Tumor Necrosis Factor is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, immune complexes, inhibitors of cyclooxygenase, and PAF (platelet activating factor). Human TNF-alpha is a non-glycosylated protein of 17 kDa and a length of 157 amino acids. Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%. TNF-alpha forms dimers and trimers.

Recombinant Human EPO
Z101435 50 µg
EUR 75
Description: EPO is predominantly synthesized and secreted by tubular and juxtatubular capillary, endothelial, and interstitial cells of the kidney. Approximately 10-15% of the total amount of EPO comes from extrarenal sources and is predominantly produced by hepatocytes and Kupffer cells of the liver. Approximately 40% of the molecular mass of EPO is due to its glycosylation. Glycosylation is an important factor determining the pharmacokinetic behaviour of EPO in vivo. Non-glycosylated Epo has an extremely short biological half life. Recombinant Human EPO is a glycosylated protein that runs at approximately 35 kDa owing to its glycosylation.

Recombinant Human EPO
Z101437 500 µg
EUR 360
Description: EPO is predominantly synthesized and secreted by tubular and juxtatubular capillary, endothelial, and interstitial cells of the kidney. Approximately 10-15% of the total amount of Epo comes from extrarenal sources and is predominantly produced by hepatocytes and Kupffer cells of the liver. Approximately 40% of the molecular mass of Epo is due to its glycosylation. Glycosylation is an important factor determining the pharmacokinetic behavior of Epo in vivo. Non-glycosylated Epo has an extremely short biological half life. It still binds to its receptor and may even have a higher specific activity in vitro.

Recombinant Human EPO
Z101439 1.0 mg
EUR 660
Description: EPO is predominantly synthesized and secreted by tubular and juxtatubular capillary, endothelial, and interstitial cells of the kidney. Approximately 10-15% of the total amount of Epo comes from extrarenal sources and is predominantly produced by hepatocytes and Kupffer cells of the liver. Approximately 40% of the molecular mass of Epo is due to its glycosylation. Glycosylation is an important factor determining the pharmacokinetic behavior of Epo in vivo. Non-glycosylated Epo has an extremely short biological half life. It still binds to its receptor and may even have a higher specific activity in vitro.

Recombinant Human SHH
Z101675 30 µg
EUR 105
Description: Highly conserved proteins, members of the Hedgehog family are widely represented throughout the animal kingdom. The three known mammalian Hedgehog proteins; Sonic (SHH), Desert (DHH) and Indian (IHH) hedgehog share a high degree of sequence and structural identity. SHH is specifically known to be expressed in fetal intestine, liver, lung and kidney. Recombinant Human SHH represents the N-product (N-terminal domain with Cys24 substituted by an Ile-Val-Ile sequence) which retains all the known signalling capabilities.

Recombinant Human SHH
Z101677 100 µg
EUR 215
Description: Highly conserved proteins, members of the Hedgehog family are widely represented throughout the animal kingdom. The three known mammalian Hedgehog proteins; Sonic (SHH), Desert (DHH) and Indian (IHH) hedgehog share a high degree of sequence and structural identity. SHH is specifically known to be expressed in fetal intestine, liver, lung and kidney. Recombinant Human SHH represents the N-product (N-terminal domain with Cys24 substituted by an Ile-Val-Ile sequence) which retains all the known signalling capabilities.

Recombinant Human SHH
Z101679 1.0 mg
EUR 1150
Description: Highly conserved proteins, members of the Hedgehog family are widely represented throughout the animal kingdom. The three known mammalian Hedgehog proteins; Sonic (SHH), Desert (DHH) and Indian (IHH) hedgehog share a high degree of sequence and structural identity. SHH is specifically known to be expressed in fetal intestine, liver, lung and kidney. Recombinant Human SHH represents the N-product (N-terminal domain with Cys24 substituted by an Ile-Val-Ile sequence) which retains all the known signalling capabilities.

Recombinant Human DHH
Z101695 50 µg
EUR 85
Description: The Desert Hedgehog protein is one of the three Hedgehog family proteins that is highly conserved and plays a role in many developmental processes in animals. DHH become biologically active following its autocatalytic cleavage. There is a high degree of residue homology between Sonic Hedgehog (SHH), Indian Hedgehog (IHH), and DHH. Despite their individual levels of expression and unique biological roles, the Hedgehog family members all use the same signalling pathway, and therefore, may be used interchangeably for some experimental purposes.

Recombinant Human DHH
Z101697 250 µg
EUR 375
Description: The Desert Hedgehog protein is one of the three Hedgehog family proteins that is highly conserved and plays a role in many developmental processes in animals. DHH become biologically active following its autocatalytic cleavage. There is a high degree of residue homology between Sonic Hedgehog (SHH), Indian Hedgehog (IHH), and DHH. Despite their individual levels of expression and unique biological roles, the Hedgehog family members all use the same signalling pathway, and therefore, may be used interchangeably for some experimental purposes.

Recombinant Human DHH
Z101699 1.0 mg
EUR 1320
Description: The Desert Hedgehog protein is one of the three Hedgehog family proteins that is highly conserved and plays a role in many developmental processes in animals. DHH become biologically active following its autocatalytic cleavage. There is a high degree of residue homology between Sonic Hedgehog (SHH), Indian Hedgehog (IHH), and DHH. Despite their individual levels of expression and unique biological roles, the Hedgehog family members all use the same signalling pathway, and therefore, may be used interchangeably for some experimental purposes.

Recombinant Human MIA
Z102045 20 µg
EUR 85
Description: MIA is a secreted, regulatory protein produced mainly by chondrocytes and malignant melanoma cells. This protein induces the metastasis of cancer cells by indirectly causing the detachment of melanoma cells from the surrounding extracellular matrix. MIA levels are now measured and used as a diagnostic tool for melanoma metastasis and rheumatoid arthritis.

Recombinant Human MIA
Z102049 1.0 mg
EUR 3195
Description: MIA is a secreted, regulatory protein produced mainly by chondrocytes and malignant melanoma cells. This protein induces the metastasis of cancer cells by indirectly causing the detachment of melanoma cells from the surrounding extracellular matrix. MIA levels are now measured and used as a diagnostic tool for melanoma metastasis and rheumatoid arthritis.

Recombinant Human IL9
Z102475 10 µg
EUR 195
Description: Interleukin 9 (IL9) is an immunoregulatory cytokine belonging to the IL-7/IL-9 cytokine family. Commonly produced by TH17 cells, IL9 acts as a hematopoietic cell regulator by preventing apoptosis and stimulates cell proliferation of T lymphocytes, erythroid cells, and mast cells. It binds to the IL9 receptor (IL9R) to activate different signal transducer and activator (STAT) proteins. It also supports IL2 and IL4 independent growth of helper T-cells and affects TH17 and Tregs through STAT3 and STAT5 signalling activation. Furthermore, IL9 has been found to be a candidate gene for asthma as its presence determines the pathogenesis of bronchial hyper-responsiveness. Although human and mouse IL9 share a 56% amino acid identity, human IL9 is not active on mouse cells and can be found to inhibit melanoma growth in mice.

Recombinant Human IL9
Z102479 1.0 mg
EUR 6900
Description: Interleukin 9 (IL9) is an immunoregulatory cytokine belonging to the IL-7/IL-9 cytokine family. Commonly produced by TH17 cells, IL9 acts as a hematopoietic cell regulator by preventing apoptosis and stimulates cell proliferation of T lymphocytes, erythroid cells, and mast cells. It binds to the IL9 receptor (IL9R) to activate different signal transducer and activator (STAT) proteins. It also supports IL2 and IL4 independent growth of helper T-cells and affects TH17 and Tregs through STAT3 and STAT5 signalling activation. Furthermore, IL9 has been found to be a candidate gene for asthma as its presence determines the pathogenesis of bronchial hyper-responsiveness. Although human and mouse IL9 share a 56% amino acid identity, human IL9 is not active on mouse cells and can be found to inhibit melanoma growth in mice.

Recombinant Human IL5
Z102625 10 µg
EUR 85
Description: Interleukin 5 (IL5) is a specific hematopoietic growth factor that is responsible for the growth and differentiation of eosinophils. IL5 promotes the growth of immature hematopoietic progenitor cells BFU-E while it causes differentiation of CFU-E the proliferation of which is inhibited by IL5. B cells can be made responsive to IL5 by treatment with suboptimal doses of IL1. Interleukin 5 also promotes the generation of cytotoxic T cells from thymocytes. In thymocytes IL5 induces the expression of high affinity IL2 receptors. Human and mouse IL5 is cross-species reactive. Recombinant Human IL5 is a 26.5 kDa disulfide-linked homodimerized protein.

Recombinant Human HGF
Z102775 10 µg
EUR 195
Description: Hepatocyte growth factor (HGF) is a multifunctional cytokine that was originally described as a mesenchymal-derived factor that regulates cell growth, cell motility, morphogenesis and angiogenesis through activation of its receptor, the transmembrane tyrosine kinase encoded by the c-Met proto-oncogene. HGF and c-Met are often co-expressed or over-expressed in a variety of human malignancies including glioblastoma and medullablastoma. The multifunctional effects of HGF: c-Met signaling in tumor cells are mediated by a network of signal transduction pathways including mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K). HGF consists of two subunits held by a disulfide bond. The alpha subunit (69 kDa) has a length of 440 amino acids and the beta subunit (34 kDa) has a length of 234 amino acids. The beta chain of the factor shows approximately 38% homology at the protein level to the serine protease domain of plasminogen. Recombinant HGF expressed in human 293 cells and has a molecular mass of 70 kDa, lower compared to the Molecular mass for this cytokine expressed in CHO cells which emphasizes the difference in post translational modifications.

Recombinant Human HGF
Z102777 1.0 mg
EUR 6300
Description: Hepatocyte growth factor (HGF) is a multifunctional cytokine that was originally described as a mesenchymal-derived factor that regulates cell growth, cell motility, morphogenesis and angiogenesis through activation of its receptor, the transmembrane tyrosine kinase encoded by the c-Met proto-oncogene. HGF and c-Met are often co-expressed or over-expressed in a variety of human malignancies including glioblastoma and medullablastoma. The multifunctional effects of HGF: c-Met signaling in tumor cells are mediated by a network of signal transduction pathways including mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K). HGF consists of two subunits held by a disulfide bond. The alpha subunit (69 kDa) has a length of 440 amino acids and the beta subunit (34 kDa) has a length of 234 amino acids. The beta chain of the factor shows approximately 38% homology at the protein level to the serine protease domain of plasminogen. Recombinant HGF expressed in human 293 cells and has a molecular mass of 70 kDa, lower compared to the Molecular mass for this cytokine expressed in CHO cells which emphasizes the difference in post translational modifications.

Recombinant Human IA2
DAG-WT1345 1 mg
EUR 1460
Description: Recombinant

Recombinant Human GAD
DAG-WT1346 1 mg
EUR 1460
Description: Recombinant

Recombinant Human LTF
LTF-155H 100mg
EUR 255.2

Recombinant Human NSE
HEENP-1402 5ug Ask for price

Recombinant Human PDI
HEENP-1601 100ug Ask for price

Recombinant Human EGF
HEGFP-0501 100ug Ask for price

Recombinant Human BNP
HEOPP-0211 100ug Ask for price

Recombinant Human C5a
HEOPP-0306 5ug Ask for price

Recombinant Human EPG
HEOPP-0503 5ug Ask for price

Recombinant Human LIF
HEOPP-1202 5ug Ask for price

Recombinant Human MIA
HEOPP-1301 5ug Ask for price

Recombinant Human MIF
HEOPP-1308 10ug Ask for price

Recombinant Human NOV
HEOPP-1407 5ug Ask for price

Recombinant Human OSM
HEOPP-1503 10ug Ask for price

Recombinant Human OPG
HEOPP-1506 10ug Ask for price

Recombinant Human PTN
HEOPP-1607 5ug Ask for price

Recombinant Human SCF
HEOPP-1902 10ug Ask for price

Recombinant Human SHH
HEOPP-1907 5ug Ask for price

Recombinant Human EGF
EPT004 10ug
EUR 23.4
Description: Recombinant Human Epidermal Growth Factor is produced by our E.coli expression system and the target gene encoding Asn971-Arg1023 is expressed.

Recombinant Human PTH
EPT146 50ug
EUR 353.4
Description: Recombinant Human Parathyroid Hormone is produced by our E.coli expression system and the target gene encoding Ser32-Gln115 is expressed.

Recombinant Human LIF
EPT153 10ug
EUR 119.4
Description: Recombinant Human Leukemia Inhibitory Factor is produced by our E.coli expression system and the target gene encoding Ser23-Phe202 is expressed.

Recombinant Human C3a
EPT178 50ug
EUR 353.4
Description: Recombinant Human Complement Component C3a is produced by our E.coli expression system and the target gene encoding Ser672-Arg748 is expressed.

Recombinant Human SCF
EPT201 50ug
EUR 209.4
Description: Recombinant Human Stem Cell Factor is produced by our E.coli expression system and the target gene encoding Glu26-Ala189 is expressed.

Recombinant Human PCT
P0010 100ug
EUR 626.83
Description: Recombinant Human protein for PCT

Recombinant Human CKB
P0020-B 100ug
EUR 626.83
Description: Recombinant Human protein for CKB

Recombinant Human CKM
P0020-M 100ug
EUR 626.83
Description: Recombinant Human protein for CKM

Recombinant Human HE4
P0034 100ug
EUR 626.83
Description: Recombinant Human protein for HE4

Recombinant Human NNE
P0040 100ug
EUR 626.83
Description: Recombinant Human protein for NNE

Recombinant Human GLA
P0494 100ug
EUR 626.83
Description: Recombinant Human protein for GLA

Recombinant human EDA
P1422 100ug Ask for price
Description: Recombinant protein for human EDA

Recombinant human ENG
P1433 100ug Ask for price
Description: Recombinant protein for human ENG

Recombinant human PXN
P1439 100ug Ask for price
Description: Recombinant protein for human PXN

Recombinant human FAS
P1464 100ug Ask for price
Description: Recombinant protein for human FAS

Recombinant human REL
P1479 100ug Ask for price
Description: Recombinant protein for human REL

Recombinant human MET
P1995 100ug Ask for price
Description: Recombinant protein for human MET

Recombinant human KIT
P1996 100ug Ask for price
Description: Recombinant protein for human KIT

Recombinant human TEC
P1997 100ug Ask for price
Description: Recombinant protein for human TEC

Recombinant human FRY
P2014 100ug Ask for price
Description: Recombinant protein for human FRY

Recombinant human VHL
P2120 100ug Ask for price
Description: Recombinant protein for human VHL

Recombinant human FEV
P2435 100ug Ask for price
Description: Recombinant protein for human FEV

Recombinant human GGN
P2440 100ug Ask for price
Description: Recombinant protein for human GGN

Recombinant human KLB
P2441 100ug Ask for price
Description: Recombinant protein for human KLB

Recombinant human DBT
P2445 100ug Ask for price
Description: Recombinant protein for human DBT

Recombinant human MT4
P2447 100ug Ask for price
Description: Recombinant protein for human MT4

In short, these findings indicate that leptin may be the main molecule that mediates the effects of adipocytes in inflammatory cells such as basophiles by binding LEPR and activating cellular functions, which may worsen allergic inflammation.

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