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Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.

Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.
Posted by Frank

target receptors androgen therapy has emerged as an effective tool for managing prostate cancer (PCa). However, the frequent occurrence of therapy resistance is a major challenge in the clinical management of the patient, as well as the molecular mechanisms behind resistance therapy is not yet fully understood.

In this study, we aimed to identify new targets for intervention with therapy resistance using gene expression analysis of PCa spheroids co-cultures in which the cells of PCa were grown in the presence of fibroblasts associated cancer (CAFS) and which had previously been shown to be reliable models for change antiandrogen resistance.Gene expression of co-culture spheroids (LNCaP and featured DuCaP together with the CAFS) identified by Illumina microarray profiles.

Real-time PCR, Western blotting, immunohistochemistry and cell viability tests in 2D and 3D cultures performed to validate the selected target expression in vitro and in vivo. cytokine profiles was conducted to analyze the CAF-conditioned medium.Gene co-culture expression analysis spheroids revealed that CAFS trigger a significant upregulation of cholesterol and steroid biosynthesis pathway in PCa cells. Cytokine profiling reveal a high number of pro-inflammatory factors, pro-migratory and pro-angiogenic in the supernatant CAF.

In particular, two genes, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (HMGCS2) and aldo-keto reductase family 1 member C3 (AKR1C3), was significantly upregulated in PCa cells in co-culture with CAFS. Both enzymes also increased significantly in human PCa compared with benign tissue with AKR1C3 expression even associated with Gleason score and metastatic status. Inhibiting HMGCS2 and AKR1C3 resulted in a significant growth retardation of spheroids co-culture as well as a variety of castration and enzalutamide resistant cell lines in 2D and 3D cultures, underlining their alleged role in PCa.

Importantly, dual targeting cholesterol and steroid biosynthesis with simvastatin, commonly prescribed cholesterol synthesis inhibitors, and inhibitors to have the strongest growth inhibitory AKR1C3 effect.From our results we conclude that the CAFS induces upregulation of cholesterol and steroid biosynthesis in PCa cells, driving them to AR targeted therapy resistance. Hinder both paths with AKR1C3 inhibitor simvastatin and therefore may be a promising approach to overcome resistance to targeted therapies AR in PCa. Video abstract.

Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.
Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.

Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an immunoregulatory Factor Mediates Airway Remodeling and Possible Pharmacological Target.

Asthma is a chronic disease of the respiratory system and heterogeneous, one of the most common lung diseases worldwide. The underlying pathology, the chronic inflammatory process and airway remodeling (AR), mediated by cells and cytokines.

Particularly interesting in this field is the platelet-derived growth factor (PDGF), one of the members of the family of human growth factors. In this article, the authors analyze the available data on the role of PDGF in asthma in experimental models and human studies. PDGF is expressed in the airway by a variety of cells contribute to the pathogenesis of asthma-mast cells, eosinophils and airway epithelial cells.

Chicken Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Ch-96T 96T
EUR 704.4
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Eq-48T 48T
EUR 603.6
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Eq-96T 96T
EUR 784.8
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Hu-48T 48T
EUR 374.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Hu-96T 96T
EUR 470.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Mu-48T 48T
EUR 522
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Mu-96T 96T
EUR 673.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 4 (IL4) ELISA Kit

DLR-IL4-p-48T 48T
EUR 591.6
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 4 (IL4) ELISA Kit

DLR-IL4-p-96T 96T
EUR 769.2
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Ra-48T 48T
EUR 372
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Ra-96T 96T
EUR 466.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Rb-48T 48T
EUR 544.8
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Rb-96T 96T
EUR 704.4
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Sheep Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Sh-48T 48T
EUR 626.4
Description: A sandwich quantitative ELISA assay kit for detection of Sheep Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Sheep Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Sh-96T 96T
EUR 817.2
Description: A sandwich quantitative ELISA assay kit for detection of Sheep Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Si-48T 48T
EUR 626.4
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Si-96T 96T
EUR 817.2
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-b-48Tests 48 Tests
EUR 619.2

Bovine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-b-96Tests 96 Tests
EUR 859.2

Canine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-c-48Tests 48 Tests
EUR 591.6

Canine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-c-96Tests 96 Tests
EUR 819.6

Chicken Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Ch-48Tests 48 Tests
EUR 564

Chicken Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Ch-96Tests 96 Tests
EUR 781.2

Equine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Eq-48Tests 48 Tests
EUR 633.6

Equine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Eq-96Tests 96 Tests
EUR 879.6

Human Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Hu-48Tests 48 Tests
EUR 362.4

Human Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Hu-96Tests 96 Tests
EUR 490.8

Mouse Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Mu-48Tests 48 Tests
EUR 536.4

Mouse Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Mu-96Tests 96 Tests
EUR 741.6

Porcine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-p-48Tests 48 Tests
EUR 619.2

Porcine Interleukin 4 (IL4) ELISA Kit

RDR-IL4-p-96Tests 96 Tests
EUR 859.2

Rat Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Ra-48Tests 48 Tests
EUR 360

Rat Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Ra-96Tests 96 Tests
EUR 488.4

Rabbit Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Rb-48Tests 48 Tests
EUR 564

Rabbit Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Rb-96Tests 96 Tests
EUR 781.2

Sheep Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Sh-48Tests 48 Tests
EUR 661.2

Sheep Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Sh-96Tests 96 Tests
EUR 918

Monkey Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Si-48Tests 48 Tests
EUR 661.2

Monkey Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Si-96Tests 96 Tests
EUR 918

Bovine Interleukin 4 (IL4) ELISA Kit

RD-IL4-b-48Tests 48 Tests
EUR 592.8

Bovine Interleukin 4 (IL4) ELISA Kit

RD-IL4-b-96Tests 96 Tests
EUR 820.8

Canine Interleukin 4 (IL4) ELISA Kit

RD-IL4-c-48Tests 48 Tests
EUR 566.4

Canine Interleukin 4 (IL4) ELISA Kit

RD-IL4-c-96Tests 96 Tests
EUR 783.6

Chicken Interleukin 4 (IL4) ELISA Kit

RD-IL4-Ch-48Tests 48 Tests
EUR 540

Chicken Interleukin 4 (IL4) ELISA Kit

RD-IL4-Ch-96Tests 96 Tests
EUR 746.4

Equine Interleukin 4 (IL4) ELISA Kit

RD-IL4-Eq-48Tests 48 Tests
EUR 606

Equine Interleukin 4 (IL4) ELISA Kit

RD-IL4-Eq-96Tests 96 Tests
EUR 840

Human Interleukin 4 (IL4) ELISA Kit

RD-IL4-Hu-48Tests 48 Tests
EUR 348

Human Interleukin 4 (IL4) ELISA Kit

RD-IL4-Hu-96Tests 96 Tests
EUR 470.4

Mouse Interleukin 4 (IL4) ELISA Kit

RD-IL4-Mu-48Tests 48 Tests
EUR 514.8

Mouse Interleukin 4 (IL4) ELISA Kit

RD-IL4-Mu-96Tests 96 Tests
EUR 709.2

Porcine Interleukin 4 (IL4) ELISA Kit

RD-IL4-p-48Tests 48 Tests
EUR 592.8

Porcine Interleukin 4 (IL4) ELISA Kit

RD-IL4-p-96Tests 96 Tests
EUR 820.8

Rat Interleukin 4 (IL4) ELISA Kit

RD-IL4-Ra-48Tests 48 Tests
EUR 345.6

Rat Interleukin 4 (IL4) ELISA Kit

RD-IL4-Ra-96Tests 96 Tests
EUR 468

Rabbit Interleukin 4 (IL4) ELISA Kit

RD-IL4-Rb-48Tests 48 Tests
EUR 540

Rabbit Interleukin 4 (IL4) ELISA Kit

RD-IL4-Rb-96Tests 96 Tests
EUR 746.4

Sheep Interleukin 4 (IL4) ELISA Kit

RD-IL4-Sh-48Tests 48 Tests
EUR 632.4

Sheep Interleukin 4 (IL4) ELISA Kit

RD-IL4-Sh-96Tests 96 Tests
EUR 877.2

Monkey Interleukin 4 (IL4) ELISA Kit

RD-IL4-Si-48Tests 48 Tests
EUR 632.4

Monkey Interleukin 4 (IL4) ELISA Kit

RD-IL4-Si-96Tests 96 Tests
EUR 877.2

Recombinant Human IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug

QP10311-ec-100ug 100ug
EUR 1044

Recombinant Macaque IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug

QP10337-ec-100ug 100ug
EUR 1228.8

Recombinant Mouse IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug

QP10453-ec-100ug 100ug
EUR 1044

Recombinant Human IL4/ Interleukin-4 Protein, His, E.coli-100ug

QP8557-ec-100ug 100ug
EUR 489.6

Recombinant Human IL4/ Interleukin-4 Protein, His, Yeast-100ug

QP8557-ye-100ug 100ug
EUR 576

Recombinant Dog IL4/ Interleukin-4 Protein, His, E.coli-100ug

QP6222-ec-100ug 100ug
EUR 848.4

Guinea pig Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Gu-48T 48T
EUR 568.8
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 4 (IL4) ELISA Kit

DLR-IL4-Gu-96T 96T
EUR 736.8
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 4 (IL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Gu-48Tests 48 Tests
EUR 591.6

Guinea pig Interleukin 4 (IL4) ELISA Kit

RDR-IL4-Gu-96Tests 96 Tests
EUR 819.6

Guinea pig Interleukin 4 (IL4) ELISA Kit

RD-IL4-Gu-48Tests 48 Tests
EUR 566.4

Guinea pig Interleukin 4 (IL4) ELISA Kit

RD-IL4-Gu-96Tests 96 Tests
EUR 783.6

Human Interleukin 4 (IL4) Protein

abx060185-100ug 100 ug
EUR 661.2

Human Interleukin 4 (IL4) Protein

abx060251-100ug 100 ug
EUR 661.2

Active Interleukin 4 (IL4)

4-APA077Hu01
  • EUR 798.46
  • EUR 337.20
  • EUR 2664.19
  • EUR 968.06
  • EUR 1816.13
  • EUR 609.60
  • EUR 6480.48
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 4 expressed in: E.coli

Active Interleukin 4 (IL4)

4-APA077Hu61
  • EUR 939.30
  • EUR 375.60
  • EUR 3192.38
  • EUR 1144.13
  • EUR 2168.26
  • EUR 704.40
  • EUR 7800.96
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 4 expressed in: 293F cell

Active Interleukin 4 (IL4)

4-APA077Mu01
  • EUR 781.25
  • EUR 332.40
  • EUR 2599.68
  • EUR 946.56
  • EUR 1773.12
  • EUR 598.80
  • EUR 6319.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 4 expressed in: E.coli

Active Interleukin 4 (IL4)

4-APA077Ra01
  • EUR 995.21
  • EUR 390.00
  • EUR 3402.05
  • EUR 1214.02
  • EUR 2308.03
  • EUR 741.60
  • EUR 8325.12
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 4 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Eukaryotic Interleukin 4 (IL4)

4-EPA077Hu61
  • EUR 831.78
  • EUR 346.80
  • EUR 2789.18
  • EUR 1009.73
  • EUR 1899.46
  • EUR 632.40
  • EUR 6792.96
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 4 expressed in: 293F cell

Eukaryotic Interleukin 4 (IL4)

4-EPA077Mu61
  • EUR 872.64
  • EUR 357.60
  • EUR 2942.40
  • EUR 1060.80
  • EUR 2001.60
  • EUR 660.00
  • EUR 7176.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 4 expressed in: 293F cell

Eukaryotic Interleukin 4 (IL4)

4-EPA077Ra61
  • EUR 874.79
  • EUR 357.60
  • EUR 2950.46
  • EUR 1063.49
  • EUR 2006.98
  • EUR 661.20
  • EUR 7196.16
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 4 expressed in: 293F cell

Recombinant Interleukin 4 (IL4)

4-RPA077Ca01
  • EUR 657.60
  • EUR 300.00
  • EUR 2136.00
  • EUR 792.00
  • EUR 1464.00
  • EUR 516.00
  • EUR 5160.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Dog Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)

4-RPA077Ga01
  • EUR 612.44
  • EUR 286.80
  • EUR 1966.66
  • EUR 735.55
  • EUR 1351.10
  • EUR 484.80
  • EUR 4736.64
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Chicken Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)

4-RPA077Hu02
  • EUR 642.55
  • EUR 295.20
  • EUR 2079.55
  • EUR 773.18
  • EUR 1426.37
  • EUR 505.20
  • EUR 5018.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)

4-RPA077Mu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)

4-RPA077Po01
  • EUR 689.86
  • EUR 308.40
  • EUR 2256.96
  • EUR 832.32
  • EUR 1544.64
  • EUR 537.60
  • EUR 5462.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)

4-RPA077Ra01
  • EUR 605.99
  • EUR 285.60
  • EUR 1942.46
  • EUR 727.49
  • EUR 1334.98
  • EUR 481.20
  • EUR 4676.16
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)

4-RPA077Rb01
  • EUR 657.60
  • EUR 300.00
  • EUR 2136.00
  • EUR 792.00
  • EUR 1464.00
  • EUR 516.00
  • EUR 5160.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rabbit Interleukin 4 expressed in: E.coli

Recombinant Sheep IL4/ Interleukin-4 Protein, His-B2M, E.coli-100ug

QP6224-ec-100ug 100ug
EUR 848.4

Interleukin 4 (IL4) Antibody

20-abx200977
  • EUR 376.80
  • EUR 594.00
  • 100 ug
  • 500 ug

Interleukin 4 (IL4) Antibody

20-abx323730
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx324014
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx324053
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx015093
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Interleukin 4 (IL4) Antibody

20-abx100944
  • EUR 360.00
  • EUR 159.60
  • EUR 944.40
  • EUR 493.20
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx100945
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx100946
  • EUR 360.00
  • EUR 844.80
  • EUR 427.20
  • EUR 184.80
  • EUR 292.80
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx100947
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx100948
  • EUR 543.60
  • EUR 159.60
  • EUR 1545.60
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx104769
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx104913
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx109942
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx110541
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx130731
  • EUR 360.00
  • EUR 159.60
  • EUR 944.40
  • EUR 493.20
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx130732
  • EUR 510.00
  • EUR 159.60
  • EUR 1462.80
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx130733
  • EUR 376.80
  • EUR 159.60
  • EUR 1028.40
  • EUR 526.80
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx130734
  • EUR 360.00
  • EUR 159.60
  • EUR 944.40
  • EUR 493.20
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx131748
  • EUR 360.00
  • EUR 844.80
  • EUR 427.20
  • EUR 184.80
  • EUR 292.80
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx129505
  • EUR 360.00
  • EUR 159.60
  • EUR 927.60
  • EUR 493.20
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 4 (IL4) Antibody

20-abx318199
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dog Interleukin-4 (IL4)

1-CSB-EP011659DO
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Dog Interleukin-4(IL4) expressed in E.coli

Human Interleukin-4 (IL4)

1-CSB-EP011659HUa0
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL4) expressed in E.coli

Sheep Interleukin-4 (IL4)

1-CSB-EP011659SH
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Sheep Interleukin-4(IL4) expressed in E.coli

Human Interleukin-4 (IL4)

1-CSB-YP011659HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL4) expressed in Yeast

Sheep Interleukin-4 (IL4)

1-CSB-YP011659SH
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Sheep Interleukin-4(IL4) expressed in Yeast

Interleukin 4 (IL4) Antibody

20-abx137090
  • EUR 427.20
  • EUR 627.60
  • 0.5 mg
  • 1 mg

Interleukin 4 (IL4) Antibody

20-abx137097
  • EUR 427.20
  • EUR 627.60
  • 0.5 mg
  • 1 mg

Interleukin 4 (IL4) Antibody

20-abx006302
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Interleukin 4 (IL4) Antibody

20-abx009115
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Interleukin 4 (IL4) Antibody

20-abx009116
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Interleukin 4 (IL4) Antibody

20-abx009117
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Interleukin 4 (IL4) Antibody

abx032452-400ul 400 ul
EUR 627.6

Interleukin 4 (IL4) Antibody

abx032452-80l 80 µl
EUR 343.2

Interleukin 4 (IL4) Antibody

20-abx270159
  • EUR 560.40
  • EUR 644.40
  • EUR 326.40
  • EUR 978.00
  • EUR 427.20
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Interleukin 4 (IL4) Antibody

20-abx270232
  • EUR 560.40
  • EUR 644.40
  • EUR 326.40
  • EUR 978.00
  • EUR 427.20
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Interleukin 4 (IL4) Antibody

abx330739-100ul 100 ul
EUR 510

Interleukin 4 (IL4) Antibody

20-abx173160
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Interleukin 4 (IL4) Antibody

20-abx173161
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

Interleukin 4 (IL4) Antibody

20-abx173162
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

The study confirms the thesis that this factor is also secreted by these cells in the course of asthma. The main effect of PDGF in the bronchus is the proliferation of airway smooth muscle cells (ASM) ASM to epithelial cell migration and enhanced collagen synthesis by pulmonary fibroblasts. AR importance in asthma is a well recognized and new therapies should also aim to manage it, perhaps targeting PDGFRs.

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