target receptors androgen therapy has emerged as an effective tool for managing prostate cancer (PCa). However, the frequent occurrence of therapy resistance is a major challenge in the clinical management of the patient, as well as the molecular mechanisms behind resistance therapy is not yet fully understood.

In this study, we aimed to identify new targets for intervention with therapy resistance using gene expression analysis of PCa spheroids co-cultures in which the cells of PCa were grown in the presence of fibroblasts associated cancer (CAFS) and which had previously been shown to be reliable models for change antiandrogen resistance.Gene expression of co-culture spheroids (LNCaP and featured DuCaP together with the CAFS) identified by Illumina microarray profiles.

Real-time PCR, Western blotting, immunohistochemistry and cell viability tests in 2D and 3D cultures performed to validate the selected target expression in vitro and in vivo. cytokine profiles was conducted to analyze the CAF-conditioned medium.Gene co-culture expression analysis spheroids revealed that CAFS trigger a significant upregulation of cholesterol and steroid biosynthesis pathway in PCa cells. Cytokine profiling reveal a high number of pro-inflammatory factors, pro-migratory and pro-angiogenic in the supernatant CAF.

In particular, two genes, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (HMGCS2) and aldo-keto reductase family 1 member C3 (AKR1C3), was significantly upregulated in PCa cells in co-culture with CAFS. Both enzymes also increased significantly in human PCa compared with benign tissue with AKR1C3 expression even associated with Gleason score and metastatic status. Inhibiting HMGCS2 and AKR1C3 resulted in a significant growth retardation of spheroids co-culture as well as a variety of castration and enzalutamide resistant cell lines in 2D and 3D cultures, underlining their alleged role in PCa.

Importantly, dual targeting cholesterol and steroid biosynthesis with simvastatin, commonly prescribed cholesterol synthesis inhibitors, and inhibitors to have the strongest growth inhibitory AKR1C3 effect.From our results we conclude that the CAFS induces upregulation of cholesterol and steroid biosynthesis in PCa cells, driving them to AR targeted therapy resistance. Hinder both paths with AKR1C3 inhibitor simvastatin and therefore may be a promising approach to overcome resistance to targeted therapies AR in PCa. Video abstract.

Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an immunoregulatory Factor Mediates Airway Remodeling and Possible Pharmacological Target.

Asthma is a chronic disease of the respiratory system and heterogeneous, one of the most common lung diseases worldwide. The underlying pathology, the chronic inflammatory process and airway remodeling (AR), mediated by cells and cytokines.

Particularly interesting in this field is the platelet-derived growth factor (PDGF), one of the members of the family of human growth factors. In this article, the authors analyze the available data on the role of PDGF in asthma in experimental models and human studies. PDGF is expressed in the airway by a variety of cells contribute to the pathogenesis of asthma-mast cells, eosinophils and airway epithelial cells.

Interleukin 4 (IL4) Antibody
20-abx109942	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx110541	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx104913	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx173160	Abbexa	EUR 1011.60 EUR 526.80	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx173161	Abbexa	EUR 1045.20 EUR 543.60	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx173162	Abbexa	EUR 1045.20 EUR 543.60	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx173163	Abbexa	EUR 1095.60 EUR 560.40	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx173164	Abbexa	EUR 1095.60 EUR 560.40	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx173165	Abbexa	EUR 1111.20 EUR 560.40	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx173166	Abbexa	EUR 1144.80 EUR 577.20	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx173167	Abbexa	EUR 1144.80 EUR 577.20	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx177170	Abbexa	EUR 1362.00 EUR 661.20	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx177172	Abbexa	EUR 1479.60 EUR 710.40	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx177173	Abbexa	EUR 1545.60 EUR 744.00	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx177174	Abbexa	EUR 1579.20 EUR 760.80	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx177175	Abbexa	EUR 1579.20 EUR 760.80	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx177176	Abbexa	EUR 1646.40 EUR 777.60	1 mg 200 ug

Interleukin 4 (IL4) Antibody
20-abx177177	Abbexa	EUR 1646.40 EUR 777.60	1 mg 200 ug

Interleukin 4 (IL4) Antibody
abx148481-100ug	Abbexa	100 ug	EUR 526.8

Interleukin 4 (IL4) Antibody
abx330739-100ul	Abbexa	100 ul	EUR 510

Interleukin 4 (IL4) Antibody
abx032452-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 4 (IL4) Antibody
abx032452-80l	Abbexa	80 µl	EUR 343.2

Interleukin 4 (IL4) Antibody
abx037033-100ug	Abbexa	100 ug	EUR 469.2

Interleukin 4 (IL4) Antibody
20-abx100944	Abbexa	EUR 360.00 EUR 159.60 EUR 944.40 EUR 493.20 EUR 309.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx100945	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx100946	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx100947	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx100948	Abbexa	EUR 543.60 EUR 159.60 EUR 1545.60 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx129505	Abbexa	EUR 360.00 EUR 159.60 EUR 927.60 EUR 493.20 EUR 309.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx130731	Abbexa	EUR 360.00 EUR 159.60 EUR 944.40 EUR 493.20 EUR 309.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx130732	Abbexa	EUR 510.00 EUR 159.60 EUR 1462.80 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx130733	Abbexa	EUR 376.80 EUR 159.60 EUR 1028.40 EUR 526.80 EUR 326.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx130734	Abbexa	EUR 360.00 EUR 159.60 EUR 944.40 EUR 493.20 EUR 309.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx131748	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx323730	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx324014	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx324053	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 4 (IL4) Antibody
20-abx006302	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin 4 (IL4) Antibody
20-abx009115	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Interleukin 4 (IL4) Antibody
20-abx009116	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Interleukin 4 (IL4) Antibody
20-abx009117	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Interleukin 4 (IL4) Antibody
20-abx015093	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Dog Interleukin-4 (IL4)
1-CSB-EP011659DO	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Dog Interleukin-4(IL4) expressed in E.coli

Active Interleukin 4 (IL4)
4-APA077Hu01	Cloud-Clone	EUR 798.46 EUR 337.20 EUR 2664.19 EUR 968.06 EUR 1816.13 EUR 609.60 EUR 6480.48	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 4 expressed in: E.coli

Active Interleukin 4 (IL4)
4-APA077Hu61	Cloud-Clone	EUR 939.30 EUR 375.60 EUR 3192.38 EUR 1144.13 EUR 2168.26 EUR 704.40 EUR 7800.96	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 4 expressed in: 293F cell

Active Interleukin 4 (IL4)
4-APA077Mu01	Cloud-Clone	EUR 781.25 EUR 332.40 EUR 2599.68 EUR 946.56 EUR 1773.12 EUR 598.80 EUR 6319.20	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 4 expressed in: E.coli

Active Interleukin 4 (IL4)
4-APA077Ra01	Cloud-Clone	EUR 995.21 EUR 390.00 EUR 3402.05 EUR 1214.02 EUR 2308.03 EUR 741.60 EUR 8325.12	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Interleukin 4 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Human Interleukin-4 (IL4)
1-CSB-YP011659HU	Cusabio	EUR 516.00 EUR 280.80 EUR 1809.60 EUR 770.40 EUR 1210.80 EUR 349.20	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Interleukin-4(IL4) expressed in Yeast

Sheep Interleukin-4 (IL4)
1-CSB-YP011659SH	Cusabio	EUR 814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Sheep Interleukin-4(IL4) expressed in Yeast

Human Interleukin-4 (IL4)
1-CSB-EP011659HUa0	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Interleukin-4(IL4) expressed in E.coli

Sheep Interleukin-4 (IL4)
1-CSB-EP011659SH	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Sheep Interleukin-4(IL4) expressed in E.coli

Active Interleukin 4 (IL4)
RPU54749-100ug	Biomatik Corporation	100ug	EUR 777.7

Active Interleukin 4 (IL4)
RPU54749-1mg	Biomatik Corporation	1mg	EUR 3445

Active Interleukin 4 (IL4)
RPU54749-50ug	Biomatik Corporation	50ug	EUR 624.8

Active Interleukin 4 (IL4)
RPU54828-100ug	Biomatik Corporation	100ug	EUR 822.8

Active Interleukin 4 (IL4)
RPU54828-1mg	Biomatik Corporation	1mg	EUR 3244.8

Active Interleukin 4 (IL4)
RPU54828-50ug	Biomatik Corporation	50ug	EUR 499.2

Active Interleukin 4 (IL4)
RPU55470-100ug	Biomatik Corporation	100ug	EUR 973.5

Active Interleukin 4 (IL4)
RPU55470-1mg	Biomatik Corporation	1mg	EUR 3837.6

Active Interleukin 4 (IL4)
RPU55470-50ug	Biomatik Corporation	50ug	EUR 590.4

Active Interleukin 4 (IL4)
RPU55471-100ug	Biomatik Corporation	100ug	EUR 1013.1

Active Interleukin 4 (IL4)
RPU55471-1mg	Biomatik Corporation	1mg	EUR 5079.1

Active Interleukin 4 (IL4)
RPU55471-50ug	Biomatik Corporation	50ug	EUR 781.5

Active Interleukin 4 (IL4)
RPU56354-100ug	Biomatik Corporation	100ug	EUR 1282.6

Active Interleukin 4 (IL4)
RPU56354-1mg	Biomatik Corporation	1mg	EUR 5054.4

Active Interleukin 4 (IL4)
RPU56354-50ug	Biomatik Corporation	50ug	EUR 777.6

Active Interleukin 4 (IL4)
RPU56358-100ug	Biomatik Corporation	100ug	EUR 1013.1

Active Interleukin 4 (IL4)
RPU56358-1mg	Biomatik Corporation	1mg	EUR 5079.1

Active Interleukin 4 (IL4)
RPU56358-50ug	Biomatik Corporation	50ug	EUR 781.5

Interleukin 4 (IL4) Antibody (PE)
20-abx200974	Abbexa	EUR 543.60 EUR 343.20	100 ug 25 ug

Interleukin 4 (IL4) Antibody (PE)
20-abx270921	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 4 (IL4) Antibody (PE)
20-abx270994	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 4 (IL4) Antibody (HRP)
20-abx314853	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody (APC)
20-abx200970	Abbexa	EUR 610.80 EUR 360.00	100 ug 25 ug

Interleukin 4 (IL4) Antibody (APC)
20-abx270689	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 4 (IL4) Antibody (APC)
20-abx270762	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 4 (IL4) Antibody (APC)
20-abx177171	Abbexa	EUR 1412.40 EUR 693.60	1 mg 200 ug

Interleukin 4 (IL4) Antibody (HRP)
20-abx108431	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody (HRP)
20-abx109098	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody (RPE)
abx413390-100tests	Abbexa	100 tests	EUR 994.8

Eukaryotic Interleukin 4 (IL4)
4-EPA077Hu61	Cloud-Clone	EUR 831.78 EUR 346.80 EUR 2789.18 EUR 1009.73 EUR 1899.46 EUR 632.40 EUR 6792.96	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 4 expressed in: 293F cell

Eukaryotic Interleukin 4 (IL4)
4-EPA077Mu61	Cloud-Clone	EUR 872.64 EUR 357.60 EUR 2942.40 EUR 1060.80 EUR 2001.60 EUR 660.00 EUR 7176.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 4 expressed in: 293F cell

Eukaryotic Interleukin 4 (IL4)
4-EPA077Ra61	Cloud-Clone	EUR 874.79 EUR 357.60 EUR 2950.46 EUR 1063.49 EUR 2006.98 EUR 661.20 EUR 7196.16	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Interleukin 4 expressed in: 293F cell

Eukaryotic Interleukin 4 (IL4)
RPU54769-100ug	Biomatik Corporation	100ug	EUR 815.1

Eukaryotic Interleukin 4 (IL4)
RPU54769-1mg	Biomatik Corporation	1mg	EUR 3614

Eukaryotic Interleukin 4 (IL4)
RPU54769-50ug	Biomatik Corporation	50ug	EUR 655.6

Eukaryotic Interleukin 4 (IL4)
RPU54798-100ug	Biomatik Corporation	100ug	EUR 862.4

Eukaryotic Interleukin 4 (IL4)
RPU54798-1mg	Biomatik Corporation	1mg	EUR 3822

Eukaryotic Interleukin 4 (IL4)
RPU54798-50ug	Biomatik Corporation	50ug	EUR 693

Eukaryotic Interleukin 4 (IL4)
RPU54799-100ug	Biomatik Corporation	100ug	EUR 864.6

Eukaryotic Interleukin 4 (IL4)
RPU54799-1mg	Biomatik Corporation	1mg	EUR 3832.4

Eukaryotic Interleukin 4 (IL4)
RPU54799-50ug	Biomatik Corporation	50ug	EUR 695.2

Eukaryotic Interleukin 4 (IL4)
RPU59271-100ug	Biomatik Corporation	100ug	EUR 1254

Eukaryotic Interleukin 4 (IL4)
RPU59271-1mg	Biomatik Corporation	1mg	EUR 5557.5

Eukaryotic Interleukin 4 (IL4)
RPU59271-50ug	Biomatik Corporation	50ug	EUR 836

Interleukin 4 (IL4) Antibody (FITC)
20-abx314854	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody (FITC)
20-abx200973	Abbexa	EUR 477.60 EUR 326.40 EUR 760.80	100 ug 25 ug 500 ug

Interleukin 4 (IL4) Antibody (FITC)
20-abx270457	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 4 (IL4) Antibody (FITC)
20-abx270530	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 4 (IL4) Antibody (FITC)
20-abx107010	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody Pair
20-abx370094	Abbexa	EUR 1545.60 EUR 1011.60	10 × 96 tests 5 × 96 tests

Interleukin 4 (IL4) Antibody Pair
20-abx370134	Abbexa	EUR 1462.80 EUR 961.20	10 × 96 tests 5 × 96 tests

Interleukin 4 (IL4) Antibody Pair
20-abx370305	Abbexa	EUR 1545.60 EUR 1011.60	10 × 96 tests 5 × 96 tests

Interleukin 4 (IL4) Antibody Pair
20-abx370499	Abbexa	EUR 2247.60 EUR 1429.20	10 × 96 tests 5 × 96 tests

Interleukin 4 (IL4) Antibody Pair
20-abx370653	Abbexa	EUR 2047.20 EUR 1312.80	10 × 96 tests 5 × 96 tests

Interleukin 4 (IL4) Antibody (FITC)
20-abx107681	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 4 (IL4) Antibody (FITC)
20-abx274591	Abbexa	EUR 560.40 EUR 292.80 EUR 1663.20 EUR 777.60 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Recombinant Interleukin 4 (IL4)
4-RPA077Ca01	Cloud-Clone	EUR 657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Dog Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)
4-RPA077Ga01	Cloud-Clone	EUR 612.44 EUR 286.80 EUR 1966.66 EUR 735.55 EUR 1351.10 EUR 484.80 EUR 4736.64	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Chicken Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)
4-RPA077Hu02	Cloud-Clone	EUR 642.55 EUR 295.20 EUR 2079.55 EUR 773.18 EUR 1426.37 EUR 505.20 EUR 5018.88	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)
4-RPA077Mu01	Cloud-Clone	EUR 603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)
4-RPA077Po01	Cloud-Clone	EUR 689.86 EUR 308.40 EUR 2256.96 EUR 832.32 EUR 1544.64 EUR 537.60 EUR 5462.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pig Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)
4-RPA077Ra01	Cloud-Clone	EUR 605.99 EUR 285.60 EUR 1942.46 EUR 727.49 EUR 1334.98 EUR 481.20 EUR 4676.16	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)
4-RPA077Rb01	Cloud-Clone	EUR 657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rabbit Interleukin 4 expressed in: E.coli

Recombinant Interleukin 4 (IL4)
RPU42303-100ug	Biomatik Corporation	100ug	EUR 653.4

Recombinant Interleukin 4 (IL4)
RPU42303-1mg	Biomatik Corporation	1mg	EUR 2893.8

Recombinant Interleukin 4 (IL4)
RPU42303-50ug	Biomatik Corporation	50ug	EUR 524.7

Recombinant Interleukin 4 (IL4)
RPU42304-100ug	Biomatik Corporation	100ug	EUR 556.6

Recombinant Interleukin 4 (IL4)
RPU42304-1mg	Biomatik Corporation	1mg	EUR 2467.4

Recombinant Interleukin 4 (IL4)
RPU42304-50ug	Biomatik Corporation	50ug	EUR 447.7

Recombinant Interleukin 4 (IL4)
RPU42305-100ug	Biomatik Corporation	100ug	EUR 616

Recombinant Interleukin 4 (IL4)
RPU42305-1mg	Biomatik Corporation	1mg	EUR 2730

Recombinant Interleukin 4 (IL4)
RPU42305-50ug	Biomatik Corporation	50ug	EUR 495

Recombinant Interleukin 4 (IL4)
RPU54429-100ug	Biomatik Corporation	100ug	EUR 599.5

Recombinant Interleukin 4 (IL4)
RPU54429-1mg	Biomatik Corporation	1mg	EUR 2653.3

Recombinant Interleukin 4 (IL4)
RPU54429-50ug	Biomatik Corporation	50ug	EUR 480.7

Recombinant Interleukin 4 (IL4)
RPU54583-100ug	Biomatik Corporation	100ug	EUR 616

Recombinant Interleukin 4 (IL4)
RPU54583-1mg	Biomatik Corporation	1mg	EUR 2730

Recombinant Interleukin 4 (IL4)
RPU54583-50ug	Biomatik Corporation	50ug	EUR 495

Recombinant Interleukin 4 (IL4)
RPU53482-100ug	Biomatik Corporation	100ug	EUR 554.4

The study confirms the thesis that this factor is also secreted by these cells in the course of asthma. The main effect of PDGF in the bronchus is the proliferation of airway smooth muscle cells (ASM) ASM to epithelial cell migration and enhanced collagen synthesis by pulmonary fibroblasts. AR importance in asthma is a well recognized and new therapies should also aim to manage it, perhaps targeting PDGFRs.