Cygnus Technologies, part of Maravai LifeSciences, is the biopharmaceutical industry’s partner in host cell protein (HCP) and other process-related impurity detection and analytics. In addition,
Hydrogen sulfide induces the synthesis of proinflammatory cytokines at the U937 human monocyte cell line through the ERK-NF-KAPPAB line.
Hydrogen sulfide (H2S) is now considered an endogenous gas mediator, which has been shown to be involved in many inflammatory countries. However, the mechanism of the proinflammatory function is
Estriol Inhibits Dermcidin Isoform-2 Induced Inflammatory Cytokine Expression Via Nitric Oxide Synthesis in Human Neutrophil.
The increase in cytokine levels such as TNF-α and IL-6 caused a surge in inflammation in acute ischemic heart disease (AIHD) .a dermcidin isoform-2 high level (DCN-2) occurs in AIHD will determine
The proinflammatory cytokine turns on the synthesis and secretion of urine trypsin inhibitors in human hepatoma cells.
Background and Objectives: Trypsin urine (UTI) inhibitors, protein inhibiting diverse synthesized with hepatocytes, are considered to play an important role not only in organ injury protection during
Human β-defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells.
AMP HBD-3 stimulates many functions of immune effector in myeloid cells and keratinocytes, especially through MAPK signaling cascade. Instead, HBD-3 reportedly neutralized the activation of T cells
Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon-gamma) production of four novel malonitrilamides.
Leflunomide is immunomodulator drugs with applications in managing rheumatoid arthritis. In this study, four new analogs (4A-D) A771726, active metabolites of Leflunomide were synthesized and
Learn at the synthesis of complement components by human kidney mesangial cells in culture. Assessment of cytokine effects.
Cultivation of kidney mesangial cells (MC) is easily established and widely used. MCs produce several complementary regulatory proteins (C). We studied whether MC synthesized components C (C3, C5,
Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.
target receptors androgen therapy has emerged as an effective tool for managing prostate cancer (PCa). However, the frequent occurrence of therapy resistance is a major challenge in the clinical
Autophagy modulation altered differentiation capacity of CD146+ cells toward endothelial cells, pericytes, and cardiomyocytes.
BACKGROUNDUntil now, a lot of effort used to enhance the regenerative potential of stem cells. In this study, we evaluated the hypothesis whether the modulation of autophagy could change
AIMS / HYPOTHESISinflammatory signals and increase the synthesis of prostaglandins play a role during the development of diabetes. The prostaglandin D2 (PGD2) receptor, GPR44 / DP2, is highly