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Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines
Posted by Frank

Background: High inflammation status despite the absence of infection is known to characterize subpopulations of people with schizophrenia who suffer from more severe cognitive deficits, less gray matter cortical, and neuropathology bad. Transcripts encoding upstream factor nuclear factor kappa B (NF-kB), a major transcriptional activator for the synthesis of pro-inflammatory cytokines, increased in the frontal cortex in schizophrenia compared with controls. However, the extent of this change certain diseases, limited to people with schizophrenia and high status neuroinflammatory, or caused by the loss of key NF-kB inhibitor (HIVEP2) found in the brains of schizophrenia, has not been tested.


Methods: Post-mortem prefrontal cortex brain samples assessed in 141 men (69 controls and 72 schizophrenia) and 13 wild-type mice and the brains of mice lacking HIVEP2 (wild-type 6, 7 KO mice). gene expression of pro-inflammatory cytokines and acute phase proteins SERPINA3 used to categorize groups biotypes neuroinflammation high and low in human samples through cluster analysis. The expression of 18 genes pathway NF-kB canonical and non-canonical assessed by qPCR in human and mouse tissues.


Results: In humans, we find non-canonical upstream activator of NF-kB are generally elevated in individuals with nerve inflammation regardless of diagnosis, supports the activation of NF-kB in both controls and people with schizophrenia when high cytokine mRNA. However, patients with schizophrenia have a high neuroinflammation weaker (or not) increased transcription of several upstream activator of the canonical NF-kB as compared to control high neuroinflammation.

Decrease HIVEP2 mRNA is specialized for patients with schizophrenia who also have high neuroinflammatory status, and we also found a decrease in NF-kB transcript is usually caused by activated microglia in mice lacking HIVEP2.


Conclusion: Collectively, our results show that higher cortical expression of pro-inflammatory cytokines and lower cortical HIVEP2 expression in a subset of people with schizophrenia is associated with NF-kB transcriptional signature is relatively weak compared to non-schizophrenic controls with high cytokine expression. We speculate that the relatively mild induction of NF-kB may reflect specific emphasis schizophrenia may be associated with a deficiency HIVEP2 in the cortex.

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines
Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines


The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

Psoriasis is an inflammatory skin disease that is often characterized by hyperproliferation of keratinocytes and infiltrating immune cells related diseases. Here, we identify a novel pro-inflammatory signaling pathways driven by cyclin-dependent kinase (CDK) 4 and 6 and the methyltransferase EZH2 as a valid target for the treatment of psoriasis. Delineation of pathways revealed that Cdk4 / 6 phosphorylated EZH2 in keratinocytes, leading to methylation induced STAT3 activation.

Furthermore, the active STAT3 resulted in induction IκBζ (IkappaBzeta), which is a pro-inflammatory transcription factor that is required for the synthesis of a key cytokine in psoriasis. Pharmacological or genetic inhibition of Cdk4 / 6 or EZH2 canceled pro-inflammatory gene expression related to psoriasis-pressing IκBζ induction in keratinocytes.

Human Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Hu-48T 48T
EUR 387.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Hu-96T 96T
EUR 488.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Mu-48T 48T
EUR 428.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Mu-96T 96T
EUR 544.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-p-48T 48T
EUR 591.6
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-p-96T 96T
EUR 769.2
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ra-48T 48T
EUR 446.4
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ra-96T 96T
EUR 570
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Rb-48T 48T
EUR 446.4
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Rb-96T 96T
EUR 570
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Si-48T 48T
EUR 691.2
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Si-96T 96T
EUR 906
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-b-48Tests 48 Tests
EUR 592.8

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-b-96Tests 96 Tests
EUR 820.8

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-c-48Tests 48 Tests
EUR 450

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-c-96Tests 96 Tests
EUR 618

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ch-48Tests 48 Tests
EUR 540

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ch-96Tests 96 Tests
EUR 746.4

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Eq-48Tests 48 Tests
EUR 606

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Eq-96Tests 96 Tests
EUR 840

Human Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Hu-48Tests 48 Tests
EUR 362.4

Human Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Hu-96Tests 96 Tests
EUR 493.2

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Mu-48Tests 48 Tests
EUR 409.2

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Mu-96Tests 96 Tests
EUR 559.2

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-p-48Tests 48 Tests
EUR 592.8

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-p-96Tests 96 Tests
EUR 820.8

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ra-48Tests 48 Tests
EUR 429.6

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ra-96Tests 96 Tests
EUR 588

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Rb-48Tests 48 Tests
EUR 429.6

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Rb-96Tests 96 Tests
EUR 588

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-b-48Tests 48 Tests
EUR 619.2

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-b-96Tests 96 Tests
EUR 859.2

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-c-48Tests 48 Tests
EUR 469.2

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-c-96Tests 96 Tests
EUR 645.6

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ch-48Tests 48 Tests
EUR 564

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ch-96Tests 96 Tests
EUR 781.2

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Eq-48Tests 48 Tests
EUR 633.6

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Eq-96Tests 96 Tests
EUR 879.6

Human Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Hu-48Tests 48 Tests
EUR 378

Human Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Hu-96Tests 96 Tests
EUR 514.8

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Mu-48Tests 48 Tests
EUR 427.2

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Mu-96Tests 96 Tests
EUR 584.4

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-p-48Tests 48 Tests
EUR 619.2

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-p-96Tests 96 Tests
EUR 859.2

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ra-48Tests 48 Tests
EUR 448.8

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ra-96Tests 96 Tests
EUR 614.4

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Rb-48Tests 48 Tests
EUR 448.8

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Rb-96Tests 96 Tests
EUR 614.4

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Si-48Tests 48 Tests
EUR 736.8

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Si-96Tests 96 Tests
EUR 1027.2

Interleukin 1 Beta (IL1B) Antibody

abx018323-100ug 100 ug
EUR 526.8

Interleukin 1 Beta (IL1B) Antibody

abx037983-100ug 100 ug
EUR 469.2

Interleukin-1 Beta (IL1B) Antibody

abx234209-100ug 100 ug
EUR 577.2

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Gu-48T 48T
EUR 465.6
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Gu-96T 96T
EUR 595.2
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Gu-48Tests 48 Tests
EUR 450

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Gu-96Tests 96 Tests
EUR 618

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Gu-48Tests 48 Tests
EUR 469.2

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Gu-96Tests 96 Tests
EUR 645.6

Human Interleukin-1 beta (IL1B)

1-CSB-EP011614HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli

Human Interleukin-1 beta (IL1B)

1-CSB-EP011614HUe0
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli

Sheep Interleukin-1 beta (IL1B)

1-CSB-EP011614SH
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in E.coli

Mouse Interleukin-1 beta (Il1b)

1-CSB-RP173474m
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Interleukin-1 beta(Il1b),partial expressed in E.coli

Sheep Interleukin-1 beta (IL1B)

1-CSB-YP011614SH
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in Yeast

Interleukin-1 Beta (IL1B) Antibody

20-abx210109
  • EUR 526.80
  • EUR 393.60
  • 100 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx329131
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx327587
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101763
  • EUR 393.60
  • EUR 159.60
  • EUR 1095.60
  • EUR 560.40
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx101764
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101765
  • EUR 410.40
  • EUR 159.60
  • EUR 1144.80
  • EUR 577.20
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101766
  • EUR 427.20
  • EUR 159.60
  • EUR 1195.20
  • EUR 594.00
  • EUR 360.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101767
  • EUR 427.20
  • EUR 159.60
  • EUR 1195.20
  • EUR 594.00
  • EUR 360.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx101768
  • EUR 543.60
  • EUR 159.60
  • EUR 1545.60
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101769
  • EUR 543.60
  • EUR 159.60
  • EUR 1545.60
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101770
  • EUR 543.60
  • EUR 159.60
  • EUR 1579.20
  • EUR 760.80
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx109931
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx109932
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx110440
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx110441
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx104871
  • EUR 543.60
  • EUR 159.60
  • EUR 1545.60
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx173025
  • EUR 360.00
  • EUR 844.80
  • EUR 427.20
  • EUR 184.80
  • EUR 292.80
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx173026
  • EUR 360.00
  • EUR 844.80
  • EUR 427.20
  • EUR 184.80
  • EUR 292.80
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx132185
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx130423
  • EUR 560.40
  • EUR 159.60
  • EUR 1646.40
  • EUR 777.60
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131952
  • EUR 410.40
  • EUR 1045.20
  • EUR 543.60
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131953
  • EUR 427.20
  • EUR 1111.20
  • EUR 560.40
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131954
  • EUR 410.40
  • EUR 1045.20
  • EUR 543.60
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131955
  • EUR 427.20
  • EUR 1095.60
  • EUR 560.40
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131956
  • EUR 393.60
  • EUR 1011.60
  • EUR 526.80
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx131957
  • EUR 360.00
  • EUR 844.80
  • EUR 427.20
  • EUR 184.80
  • EUR 292.80
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx131958
  • EUR 427.20
  • EUR 1095.60
  • EUR 560.40
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx128522
  • EUR 376.80
  • EUR 159.60
  • EUR 978.00
  • EUR 510.00
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx129733
  • EUR 393.60
  • EUR 159.60
  • EUR 1095.60
  • EUR 560.40
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx177056
  • EUR 376.80
  • EUR 159.60
  • EUR 978.00
  • EUR 510.00
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx177057
  • EUR 393.60
  • EUR 159.60
  • EUR 1095.60
  • EUR 560.40
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx177058
  • EUR 410.40
  • EUR 159.60
  • EUR 1195.20
  • EUR 594.00
  • EUR 360.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Eukaryotic Interleukin 1 Beta (IL1b)

4-EPA563Hu61
  • EUR 958.66
  • EUR 380.40
  • EUR 3264.96
  • EUR 1168.32
  • EUR 2216.64
  • EUR 717.60
  • EUR 7982.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell

Eukaryotic Interleukin 1 Beta (IL1b)

4-EPA563Mu61
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: 293F cell

Active Interleukin 1 Beta (IL1b)

4-APA563Hu01
  • EUR 1280.14
  • EUR 466.80
  • EUR 4470.53
  • EUR 1570.18
  • EUR 3020.35
  • EUR 932.40
  • EUR 10996.32
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli

Active Interleukin 1 Beta (IL1b)

4-APA563Hu61
  • EUR 1051.13
  • EUR 404.40
  • EUR 3611.71
  • EUR 1283.90
  • EUR 2447.81
  • EUR 778.80
  • EUR 8849.28
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Bo01
  • EUR 644.70
  • EUR 296.40
  • EUR 2087.62
  • EUR 775.87
  • EUR 1431.74
  • EUR 506.40
  • EUR 5039.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Bo02
  • EUR 644.70
  • EUR 296.40
  • EUR 2087.62
  • EUR 775.87
  • EUR 1431.74
  • EUR 506.40
  • EUR 5039.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ca01
  • EUR 657.60
  • EUR 300.00
  • EUR 2136.00
  • EUR 792.00
  • EUR 1464.00
  • EUR 516.00
  • EUR 5160.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Dog Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Eq01
  • EUR 700.61
  • EUR 310.80
  • EUR 2297.28
  • EUR 845.76
  • EUR 1571.52
  • EUR 544.80
  • EUR 5563.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Horse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Fi01
  • EUR 652.22
  • EUR 297.60
  • EUR 2115.84
  • EUR 785.28
  • EUR 1450.56
  • EUR 512.40
  • EUR 5109.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Zebrafish Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ga01
  • EUR 657.60
  • EUR 300.00
  • EUR 2136.00
  • EUR 792.00
  • EUR 1464.00
  • EUR 516.00
  • EUR 5160.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Chicken Interleukin 1 Beta expressed in: Prokaryotic expression

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Gu01
  • EUR 528.58
  • EUR 265.20
  • EUR 1652.16
  • EUR 630.72
  • EUR 1141.44
  • EUR 429.60
  • EUR 3950.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Guinea pig Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Hu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Mu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Mu02
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ov01
  • EUR 644.70
  • EUR 296.40
  • EUR 2087.62
  • EUR 775.87
  • EUR 1431.74
  • EUR 506.40
  • EUR 5039.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Sheep Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Po01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ra01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Rb01
  • EUR 464.06
  • EUR 247.20
  • EUR 1410.24
  • EUR 550.08
  • EUR 980.16
  • EUR 386.40
  • EUR 3345.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rabbit Interleukin 1 Beta expressed in: E.coli

Anti-IL1 beta/Il1b Antibody

A00101-1 100ug/vial
EUR 352.8

Interleukin 1 Beta (IL1B) Antibody

abx159562-100ul 100 ul
EUR 560.4

Interleukin 1 Beta (IL1b) Antibody

20-abx173027
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx173028
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx173029
  • EUR 1144.80
  • EUR 577.20
  • 1 mg
  • 200 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx173030
  • EUR 1144.80
  • EUR 577.20
  • 1 mg
  • 200 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx136150
  • EUR 594.00
  • EUR 427.20
  • 100 ul
  • 50 ul

Interleukin 1 Beta (IL1B) Antibody

20-abx137010
  • EUR 427.20
  • EUR 627.60
  • 0.5 mg
  • 1 mg

Interleukin 1 Beta (IL1B) Antibody

20-abx137171
  • EUR 510.00
  • EUR 777.60
  • 0.5 mg
  • 1 mg

Interleukin 1 Beta (IL1B) Antibody

20-abx137172
  • EUR 510.00
  • EUR 777.60
  • 0.5 mg
  • 1 mg

Interleukin 1 Beta (IL1B) Antibody

20-abx141200
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

The important thing, the topical application of Cdk4 / 6 or EZH2 inhibitor on the skin is enough to completely prevent the development of psoriasis in a variety of mouse models to suppress STAT3-mediated expression of IκBζ. In addition, we found a hyperactivation of the pathway Cdk4 / 6-EZH2 in human skin lesions and psoriasis mice.

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