Background: High inflammation status despite the absence of infection is known to characterize subpopulations of people with schizophrenia who suffer from more severe cognitive deficits, less gray matter cortical, and neuropathology bad. Transcripts encoding upstream factor nuclear factor kappa B (NF-kB), a major transcriptional activator for the synthesis of pro-inflammatory cytokines, increased in the frontal cortex in schizophrenia compared with controls. However, the extent of this change certain diseases, limited to people with schizophrenia and high status neuroinflammatory, or caused by the loss of key NF-kB inhibitor (HIVEP2) found in the brains of schizophrenia, has not been tested.
Methods: Post-mortem prefrontal cortex brain samples assessed in 141 men (69 controls and 72 schizophrenia) and 13 wild-type mice and the brains of mice lacking HIVEP2 (wild-type 6, 7 KO mice). gene expression of pro-inflammatory cytokines and acute phase proteins SERPINA3 used to categorize groups biotypes neuroinflammation high and low in human samples through cluster analysis. The expression of 18 genes pathway NF-kB canonical and non-canonical assessed by qPCR in human and mouse tissues.
Results: In humans, we find non-canonical upstream activator of NF-kB are generally elevated in individuals with nerve inflammation regardless of diagnosis, supports the activation of NF-kB in both controls and people with schizophrenia when high cytokine mRNA. However, patients with schizophrenia have a high neuroinflammation weaker (or not) increased transcription of several upstream activator of the canonical NF-kB as compared to control high neuroinflammation.
Decrease HIVEP2 mRNA is specialized for patients with schizophrenia who also have high neuroinflammatory status, and we also found a decrease in NF-kB transcript is usually caused by activated microglia in mice lacking HIVEP2.
Conclusion: Collectively, our results show that higher cortical expression of pro-inflammatory cytokines and lower cortical HIVEP2 expression in a subset of people with schizophrenia is associated with NF-kB transcriptional signature is relatively weak compared to non-schizophrenic controls with high cytokine expression. We speculate that the relatively mild induction of NF-kB may reflect specific emphasis schizophrenia may be associated with a deficiency HIVEP2 in the cortex.

The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis
Psoriasis is an inflammatory skin disease that is often characterized by hyperproliferation of keratinocytes and infiltrating immune cells related diseases. Here, we identify a novel pro-inflammatory signaling pathways driven by cyclin-dependent kinase (CDK) 4 and 6 and the methyltransferase EZH2 as a valid target for the treatment of psoriasis. Delineation of pathways revealed that Cdk4 / 6 phosphorylated EZH2 in keratinocytes, leading to methylation induced STAT3 activation.
Furthermore, the active STAT3 resulted in induction IκBζ (IkappaBzeta), which is a pro-inflammatory transcription factor that is required for the synthesis of a key cytokine in psoriasis. Pharmacological or genetic inhibition of Cdk4 / 6 or EZH2 canceled pro-inflammatory gene expression related to psoriasis-pressing IκBζ induction in keratinocytes.
Interleukin 1 Beta (IL1b) Antibody |
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20-abx104871 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx101763 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx101764 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx101765 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx101766 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx101767 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx101768 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx101769 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx173025 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx173026 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx173027 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx173028 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx173029 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx173030 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx177056 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx177057 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx177058 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx177060 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx213056 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx213454 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx141200 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx327587 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx113231 | Abbexa |
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Interleukin 1 beta (IL1B) Antibody |
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abx023975-1mg | Abbexa | 1 mg | EUR 961.2 |
Interleukin 1 beta (IL1B) Antibody |
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abx023976-1mg | Abbexa | 1 mg | EUR 961.2 |
Interleukin 1 Beta (IL1B) Antibody |
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abx025489-100ul | Abbexa | 100 ul | EUR 627.6 |
Interleukin 1 Beta (IL1B) Antibody |
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abx033984-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 1 Beta (IL1B) Antibody |
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abx033984-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 1 Beta (IL1B) Antibody |
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abx018323-100ug | Abbexa | 100 ug | EUR 526.8 |
Interleukin 1 Beta (IL1B) Antibody |
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abx037983-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 1 Beta (IL1b) Antibody |
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20-abx101770 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx128522 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx131952 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx131953 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx131954 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx131955 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx131956 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx131957 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx131958 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx132185 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx125995 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx125996 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx129733 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody |
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20-abx130423 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx329131 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx009120 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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20-abx001029 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody |
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abx011665-100ul | Abbexa | 100 ul | EUR 493.2 |
Interleukin 1 Beta (IL1B) Antibody |
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abx159562-100ul | Abbexa | 100 ul | EUR 560.4 |
Interleukin-1 Beta (IL1B) Antibody |
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20-abx210109 | Abbexa |
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Interleukin-1 Beta (IL1B) Antibody |
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abx234209-100ug | Abbexa | 100 ug | EUR 577.2 |
Interleukin-1 Beta (IL1B) Antibody |
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abx432851-200ul | Abbexa | 200 ul | EUR 460.8 |
Active Interleukin 1 Beta (IL1b) |
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4-APA563Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli |
Active Interleukin 1 Beta (IL1b) |
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4-APA563Hu61 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell |
Mouse Interleukin-1 beta (Il1b) |
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1-CSB-RP173474m | Cusabio |
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Description: Recombinant Mouse Interleukin-1 beta(Il1b),partial expressed in E.coli |
Sheep Interleukin-1 beta (IL1B) |
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1-CSB-YP011614SH | Cusabio |
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Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in Yeast |
Human Interleukin-1 beta (IL1B) |
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1-CSB-EP011614HU | Cusabio |
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Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli |
Human Interleukin-1 beta (IL1B) |
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1-CSB-EP011614HUe0 | Cusabio |
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Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli |
Sheep Interleukin-1 beta (IL1B) |
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1-CSB-EP011614SH | Cusabio |
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Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in E.coli |
Interleukin 1 Beta (IL1b) Antibody (APC) |
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20-abx177059 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (HRP) |
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20-abx108419 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (HRP) |
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20-abx108420 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (HRP) |
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20-abx108994 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (HRP) |
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20-abx108995 | Abbexa |
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Eukaryotic Interleukin 1 Beta (IL1b) |
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4-EPA563Hu61 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell |
Eukaryotic Interleukin 1 Beta (IL1b) |
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4-EPA563Mu61 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Beta expressed in: 293F cell |
Interleukin 1 Beta (IL1B) Antibody (FITC) |
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20-abx106998 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (FITC) |
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20-abx106999 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (FITC) |
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20-abx107575 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (FITC) |
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20-abx107576 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody Pair |
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abx117322-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Interleukin 1 Beta (Il1b) Antibody Pair |
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abx117577-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Interleukin 1 Beta (IL1B) Antibody Pair |
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abx117659-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Interleukin 1 Beta (IL1b) Antibody Pair |
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20-abx370096 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody Pair |
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20-abx370327 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody Pair |
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20-abx370594 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody Pair |
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20-abx370668 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody Pair |
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20-abx370671 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (FITC) |
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20-abx273528 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (FITC) |
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20-abx274132 | Abbexa |
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Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Bo02 | Cloud-Clone |
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Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Ca01 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Eq01 | Cloud-Clone |
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Description: Recombinant Horse Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Fi01 | Cloud-Clone |
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Description: Recombinant Zebrafish Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Ga01 | Cloud-Clone |
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Description: Recombinant Chicken Interleukin 1 Beta expressed in: Prokaryotic expression |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Gu01 | Cloud-Clone |
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Description: Recombinant Guinea pig Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Ov01 | Cloud-Clone |
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Description: Recombinant Sheep Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Po01 | Cloud-Clone |
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Description: Recombinant Pig Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Ra01 | Cloud-Clone |
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Description: Recombinant Rat Interleukin 1 Beta expressed in: E.coli |
Recombinant Interleukin 1 Beta (IL1b) |
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4-RPA563Rb01 | Cloud-Clone |
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Description: Recombinant Rabbit Interleukin 1 Beta expressed in: E.coli |
Interleukin 1 Beta (IL1b) Antibody (Biotin) |
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20-abx271689 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (Biotin) |
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20-abx271736 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (Biotin) |
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20-abx105580 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (Biotin) |
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20-abx105581 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (Biotin) |
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20-abx106162 | Abbexa |
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Interleukin 1 Beta (IL1B) Antibody (Biotin) |
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20-abx106163 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (Biotin) |
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20-abx272709 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (Biotin) |
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20-abx273058 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (Biotin) |
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20-abx273183 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (Biotin) |
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20-abx274442 | Abbexa |
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Interleukin 1 Beta (IL1b) Antibody (Biotin) |
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20-abx274505 | Abbexa |
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Pig Interleukin 1 Beta (IL1B) Protein |
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20-abx262199 | Abbexa |
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Rat Interleukin 1 Beta (IL1B) Protein |
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20-abx262247 | Abbexa |
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Dog Interleukin 1 Beta (IL1b) Protein |
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20-abx067387 | Abbexa |
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Pig Interleukin 1 Beta (IL1b) Protein |
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20-abx067391 | Abbexa |
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Rat Interleukin 1 Beta (IL1b) Protein |
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20-abx067392 | Abbexa |
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Cow Interleukin 1 Beta (IL1B) Protein |
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abx670122-20ug | Abbexa | 20 ug | EUR 777.6 |
Dog Interleukin 1 Beta (IL1B) Protein |
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abx670155-5ug | Abbexa | 5 ug | EUR 493.2 |
Rat Interleukin 1 Beta (IL1B) Protein |
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abx670342-10ug | Abbexa | 10 ug | EUR 661.2 |
Cow Interleukin 1 Beta (IL1b) Protein |
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20-abx166303 | Abbexa |
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Mouse Interleukin 1 Beta (IL1B) Protein |
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20-abx261662 | Abbexa |
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Human Interleukin 1 Beta (IL1B) Protein |
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20-abx261818 | Abbexa |
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Human Interleukin 1 Beta (IL1B) Protein |
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20-abx261854 | Abbexa |
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Horse Interleukin 1 Beta (IL1B) Protein |
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20-abx262251 | Abbexa |
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Human Interleukin 1 Beta (IL1B) Protein |
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20-abx263010 | Abbexa |
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Horse Interleukin 1 Beta (IL1b) Protein |
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20-abx067388 | Abbexa |
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Mouse Interleukin 1 Beta (IL1b) Protein |
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20-abx067390 | Abbexa |
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Mouse Interleukin 1 Beta (IL1b) Protein |
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20-abx167258 | Abbexa |
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Sheep Interleukin 1 Beta (IL1b) Protein |
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20-abx167806 | Abbexa |
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Human Interleukin 1 Beta (IL1b) Protein |
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20-abx651514 | Abbexa |
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Mouse Interleukin 1 Beta (IL1b) Protein |
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20-abx651515 | Abbexa |
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The important thing, the topical application of Cdk4 / 6 or EZH2 inhibitor on the skin is enough to completely prevent the development of psoriasis in a variety of mouse models to suppress STAT3-mediated expression of IκBζ. In addition, we found a hyperactivation of the pathway Cdk4 / 6-EZH2 in human skin lesions and psoriasis mice.