Background: High inflammation status despite the absence of infection is known to characterize subpopulations of people with schizophrenia who suffer from more severe cognitive deficits, less gray matter cortical, and neuropathology bad. Transcripts encoding upstream factor nuclear factor kappa B (NF-kB), a major transcriptional activator for the synthesis of pro-inflammatory cytokines, increased in the frontal cortex in schizophrenia compared with controls. However, the extent of this change certain diseases, limited to people with schizophrenia and high status neuroinflammatory, or caused by the loss of key NF-kB inhibitor (HIVEP2) found in the brains of schizophrenia, has not been tested.

Methods: Post-mortem prefrontal cortex brain samples assessed in 141 men (69 controls and 72 schizophrenia) and 13 wild-type mice and the brains of mice lacking HIVEP2 (wild-type 6, 7 KO mice). gene expression of pro-inflammatory cytokines and acute phase proteins SERPINA3 used to categorize groups biotypes neuroinflammation high and low in human samples through cluster analysis. The expression of 18 genes pathway NF-kB canonical and non-canonical assessed by qPCR in human and mouse tissues.

Results: In humans, we find non-canonical upstream activator of NF-kB are generally elevated in individuals with nerve inflammation regardless of diagnosis, supports the activation of NF-kB in both controls and people with schizophrenia when high cytokine mRNA. However, patients with schizophrenia have a high neuroinflammation weaker (or not) increased transcription of several upstream activator of the canonical NF-kB as compared to control high neuroinflammation.

Decrease HIVEP2 mRNA is specialized for patients with schizophrenia who also have high neuroinflammatory status, and we also found a decrease in NF-kB transcript is usually caused by activated microglia in mice lacking HIVEP2.

Conclusion: Collectively, our results show that higher cortical expression of pro-inflammatory cytokines and lower cortical HIVEP2 expression in a subset of people with schizophrenia is associated with NF-kB transcriptional signature is relatively weak compared to non-schizophrenic controls with high cytokine expression. We speculate that the relatively mild induction of NF-kB may reflect specific emphasis schizophrenia may be associated with a deficiency HIVEP2 in the cortex.

The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

Psoriasis is an inflammatory skin disease that is often characterized by hyperproliferation of keratinocytes and infiltrating immune cells related diseases. Here, we identify a novel pro-inflammatory signaling pathways driven by cyclin-dependent kinase (CDK) 4 and 6 and the methyltransferase EZH2 as a valid target for the treatment of psoriasis. Delineation of pathways revealed that Cdk4 / 6 phosphorylated EZH2 in keratinocytes, leading to methylation induced STAT3 activation.

Furthermore, the active STAT3 resulted in induction IκBζ (IkappaBzeta), which is a pro-inflammatory transcription factor that is required for the synthesis of a key cytokine in psoriasis. Pharmacological or genetic inhibition of Cdk4 / 6 or EZH2 canceled pro-inflammatory gene expression related to psoriasis-pressing IκBζ induction in keratinocytes.

Interleukin 1 Beta (IL1b) Antibody
20-abx104871	Abbexa	EUR 543.60 EUR 159.60 EUR 1545.60 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx101763	Abbexa	EUR 393.60 EUR 159.60 EUR 1095.60 EUR 560.40 EUR 343.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx101764	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx101765	Abbexa	EUR 410.40 EUR 159.60 EUR 1144.80 EUR 577.20 EUR 343.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx101766	Abbexa	EUR 427.20 EUR 159.60 EUR 1195.20 EUR 594.00 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx101767	Abbexa	EUR 427.20 EUR 159.60 EUR 1195.20 EUR 594.00 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx101768	Abbexa	EUR 543.60 EUR 159.60 EUR 1545.60 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx101769	Abbexa	EUR 543.60 EUR 159.60 EUR 1545.60 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx173025	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx173026	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx173027	Abbexa	EUR 1011.60 EUR 526.80	1 mg 200 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx173028	Abbexa	EUR 1095.60 EUR 560.40	1 mg 200 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx173029	Abbexa	EUR 1144.80 EUR 577.20	1 mg 200 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx173030	Abbexa	EUR 1144.80 EUR 577.20	1 mg 200 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx177056	Abbexa	EUR 376.80 EUR 159.60 EUR 978.00 EUR 510.00 EUR 326.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx177057	Abbexa	EUR 393.60 EUR 159.60 EUR 1095.60 EUR 560.40 EUR 343.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx177058	Abbexa	EUR 410.40 EUR 159.60 EUR 1195.20 EUR 594.00 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx177060	Abbexa	EUR 1646.40 EUR 777.60	1 mg 200 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx213056	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 1 Beta (IL1B) Antibody
20-abx213454	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 1 Beta (IL1B) Antibody
20-abx141200	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

Interleukin 1 Beta (IL1B) Antibody
20-abx327587	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx113231	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Interleukin 1 beta (IL1B) Antibody
abx023975-1mg	Abbexa	1 mg	EUR 961.2

Interleukin 1 beta (IL1B) Antibody
abx023976-1mg	Abbexa	1 mg	EUR 961.2

Interleukin 1 Beta (IL1B) Antibody
abx025489-100ul	Abbexa	100 ul	EUR 627.6

Interleukin 1 Beta (IL1B) Antibody
abx033984-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 1 Beta (IL1B) Antibody
abx033984-80l	Abbexa	80 µl	EUR 343.2

Interleukin 1 Beta (IL1B) Antibody
abx018323-100ug	Abbexa	100 ug	EUR 526.8

Interleukin 1 Beta (IL1B) Antibody
abx037983-100ug	Abbexa	100 ug	EUR 469.2

Interleukin 1 Beta (IL1b) Antibody
20-abx101770	Abbexa	EUR 543.60 EUR 159.60 EUR 1579.20 EUR 760.80 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx128522	Abbexa	EUR 376.80 EUR 159.60 EUR 978.00 EUR 510.00 EUR 326.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx131952	Abbexa	EUR 410.40 EUR 1045.20 EUR 543.60 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx131953	Abbexa	EUR 427.20 EUR 1111.20 EUR 560.40 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx131954	Abbexa	EUR 410.40 EUR 1045.20 EUR 543.60 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx131955	Abbexa	EUR 427.20 EUR 1095.60 EUR 560.40 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx131956	Abbexa	EUR 393.60 EUR 1011.60 EUR 526.80 EUR 184.80 EUR 309.60	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx131957	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx131958	Abbexa	EUR 427.20 EUR 1095.60 EUR 560.40 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx132185	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx125995	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin 1 Beta (IL1B) Antibody
20-abx125996	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin 1 Beta (IL1b) Antibody
20-abx129733	Abbexa	EUR 393.60 EUR 159.60 EUR 1095.60 EUR 560.40 EUR 343.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody
20-abx130423	Abbexa	EUR 560.40 EUR 159.60 EUR 1646.40 EUR 777.60 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx329131	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody
20-abx009120	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Interleukin 1 Beta (IL1B) Antibody
20-abx001029	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin 1 Beta (IL1B) Antibody
abx011665-100ul	Abbexa	100 ul	EUR 493.2

Interleukin 1 Beta (IL1B) Antibody
abx159562-100ul	Abbexa	100 ul	EUR 560.4

Interleukin-1 Beta (IL1B) Antibody
20-abx210109	Abbexa	EUR 526.80 EUR 393.60	100 ug 50 ug

Interleukin-1 Beta (IL1B) Antibody
abx234209-100ug	Abbexa	100 ug	EUR 577.2

Interleukin-1 Beta (IL1B) Antibody
abx432851-200ul	Abbexa	200 ul	EUR 460.8

Active Interleukin 1 Beta (IL1b)
4-APA563Hu01	Cloud-Clone	EUR 1280.14 EUR 466.80 EUR 4470.53 EUR 1570.18 EUR 3020.35 EUR 932.40 EUR 10996.32	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli

Active Interleukin 1 Beta (IL1b)
4-APA563Hu61	Cloud-Clone	EUR 1051.13 EUR 404.40 EUR 3611.71 EUR 1283.90 EUR 2447.81 EUR 778.80 EUR 8849.28	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell

Mouse Interleukin-1 beta (Il1b)
1-CSB-RP173474m	Cusabio	EUR 606.00 EUR 318.00 EUR 2192.40 EUR 919.20 EUR 1461.60 EUR 402.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Mouse Interleukin-1 beta(Il1b),partial expressed in E.coli

Sheep Interleukin-1 beta (IL1B)
1-CSB-YP011614SH	Cusabio	EUR 814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in Yeast

Human Interleukin-1 beta (IL1B)
1-CSB-EP011614HU	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli

Human Interleukin-1 beta (IL1B)
1-CSB-EP011614HUe0	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli

Sheep Interleukin-1 beta (IL1B)
1-CSB-EP011614SH	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in E.coli

Interleukin 1 Beta (IL1b) Antibody (APC)
20-abx177059	Abbexa	EUR 1412.40 EUR 693.60	1 mg 200 ug

Interleukin 1 Beta (IL1B) Antibody (HRP)
20-abx108419	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (HRP)
20-abx108420	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (HRP)
20-abx108994	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (HRP)
20-abx108995	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Eukaryotic Interleukin 1 Beta (IL1b)
4-EPA563Hu61	Cloud-Clone	EUR 958.66 EUR 380.40 EUR 3264.96 EUR 1168.32 EUR 2216.64 EUR 717.60 EUR 7982.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell

Eukaryotic Interleukin 1 Beta (IL1b)
4-EPA563Mu61	Cloud-Clone	EUR 550.08 EUR 271.20 EUR 1732.80 EUR 657.60 EUR 1195.20 EUR 444.00 EUR 4152.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: 293F cell

Interleukin 1 Beta (IL1B) Antibody (FITC)
20-abx106998	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (FITC)
20-abx106999	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (FITC)
20-abx107575	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (FITC)
20-abx107576	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody Pair
abx117322-1pair5x96wellplates	Abbexa	1 pair (5x96 well plates)	EUR 1212

Interleukin 1 Beta (Il1b) Antibody Pair
abx117577-1pair5x96wellplates	Abbexa	1 pair (5x96 well plates)	EUR 1212

Interleukin 1 Beta (IL1B) Antibody Pair
abx117659-1pair5x96wellplates	Abbexa	1 pair (5x96 well plates)	EUR 1212

Interleukin 1 Beta (IL1b) Antibody Pair
20-abx370096	Abbexa	EUR 1395.60 EUR 910.80	10 × 96 tests 5 × 96 tests

Interleukin 1 Beta (IL1b) Antibody Pair
20-abx370327	Abbexa	EUR 1412.40 EUR 927.60	10 × 96 tests 5 × 96 tests

Interleukin 1 Beta (IL1b) Antibody Pair
20-abx370594	Abbexa	EUR 1562.40 EUR 1011.60	10 × 96 tests 5 × 96 tests

Interleukin 1 Beta (IL1b) Antibody Pair
20-abx370668	Abbexa	EUR 1713.60 EUR 1111.20	10 × 96 tests 5 × 96 tests

Interleukin 1 Beta (IL1b) Antibody Pair
20-abx370671	Abbexa	EUR 2247.60 EUR 1429.20	10 × 96 tests 5 × 96 tests

Interleukin 1 Beta (IL1b) Antibody (FITC)
20-abx273528	Abbexa	EUR 493.20 EUR 276.00 EUR 1395.60 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody (FITC)
20-abx274132	Abbexa	EUR 493.20 EUR 276.00 EUR 1345.20 EUR 661.20 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Bo01	Cloud-Clone	EUR 644.70 EUR 296.40 EUR 2087.62 EUR 775.87 EUR 1431.74 EUR 506.40 EUR 5039.04	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Bo02	Cloud-Clone	EUR 644.70 EUR 296.40 EUR 2087.62 EUR 775.87 EUR 1431.74 EUR 506.40 EUR 5039.04	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Ca01	Cloud-Clone	EUR 657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Dog Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Eq01	Cloud-Clone	EUR 700.61 EUR 310.80 EUR 2297.28 EUR 845.76 EUR 1571.52 EUR 544.80 EUR 5563.20	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Horse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Fi01	Cloud-Clone	EUR 652.22 EUR 297.60 EUR 2115.84 EUR 785.28 EUR 1450.56 EUR 512.40 EUR 5109.60	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Zebrafish Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Ga01	Cloud-Clone	EUR 657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Chicken Interleukin 1 Beta expressed in: Prokaryotic expression

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Gu01	Cloud-Clone	EUR 528.58 EUR 265.20 EUR 1652.16 EUR 630.72 EUR 1141.44 EUR 429.60 EUR 3950.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Guinea pig Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Hu01	Cloud-Clone	EUR 550.08 EUR 271.20 EUR 1732.80 EUR 657.60 EUR 1195.20 EUR 444.00 EUR 4152.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Mu01	Cloud-Clone	EUR 582.34 EUR 279.60 EUR 1853.76 EUR 697.92 EUR 1275.84 EUR 465.60 EUR 4454.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Mu02	Cloud-Clone	EUR 582.34 EUR 279.60 EUR 1853.76 EUR 697.92 EUR 1275.84 EUR 465.60 EUR 4454.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Ov01	Cloud-Clone	EUR 644.70 EUR 296.40 EUR 2087.62 EUR 775.87 EUR 1431.74 EUR 506.40 EUR 5039.04	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Sheep Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Po01	Cloud-Clone	EUR 614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pig Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Ra01	Cloud-Clone	EUR 550.08 EUR 271.20 EUR 1732.80 EUR 657.60 EUR 1195.20 EUR 444.00 EUR 4152.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)
4-RPA563Rb01	Cloud-Clone	EUR 464.06 EUR 247.20 EUR 1410.24 EUR 550.08 EUR 980.16 EUR 386.40 EUR 3345.60	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rabbit Interleukin 1 Beta expressed in: E.coli

Interleukin 1 Beta (IL1b) Antibody (Biotin)
20-abx271689	Abbexa	EUR 477.60 EUR 276.00 EUR 1296.00 EUR 644.40 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody (Biotin)
20-abx271736	Abbexa	EUR 577.20 EUR 292.80 EUR 1713.60 EUR 811.20 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (Biotin)
20-abx105580	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (Biotin)
20-abx105581	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (Biotin)
20-abx106162	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1B) Antibody (Biotin)
20-abx106163	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody (Biotin)
20-abx272709	Abbexa	EUR 410.40 EUR 260.40 EUR 1195.20 EUR 594.00 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody (Biotin)
20-abx273058	Abbexa	EUR 526.80 EUR 292.80 EUR 1528.80 EUR 727.20 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody (Biotin)
20-abx273183	Abbexa	EUR 427.20 EUR 276.00 EUR 1245.60 EUR 610.80 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody (Biotin)
20-abx274442	Abbexa	EUR 477.60 EUR 260.40 EUR 1178.40 EUR 594.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 1 Beta (IL1b) Antibody (Biotin)
20-abx274505	Abbexa	EUR 427.20 EUR 243.60 EUR 1128.00 EUR 577.20 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pig Interleukin 1 Beta (IL1B) Protein
20-abx262199	Abbexa	EUR 393.60 EUR 6991.20 EUR 276.00	10 ug 1 mg 2 µg

Rat Interleukin 1 Beta (IL1B) Protein
20-abx262247	Abbexa	EUR 393.60 EUR 6991.20 EUR 276.00	10 ug 1 mg 2 µg

Dog Interleukin 1 Beta (IL1b) Protein
20-abx067387	Abbexa	EUR 910.80 EUR 360.00 EUR 2865.60 EUR 1095.60 EUR 644.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pig Interleukin 1 Beta (IL1b) Protein
20-abx067391	Abbexa	EUR 861.60 EUR 343.20 EUR 2665.20 EUR 1028.40 EUR 610.80	100 ug 10 ug 1 mg 200 ug 50 ug

Rat Interleukin 1 Beta (IL1b) Protein
20-abx067392	Abbexa	EUR 777.60 EUR 326.40 EUR 2331.60 EUR 910.80 EUR 560.40	100 ug 10 ug 1 mg 200 ug 50 ug

Cow Interleukin 1 Beta (IL1B) Protein
abx670122-20ug	Abbexa	20 ug	EUR 777.6

Dog Interleukin 1 Beta (IL1B) Protein
abx670155-5ug	Abbexa	5 ug	EUR 493.2

Rat Interleukin 1 Beta (IL1B) Protein
abx670342-10ug	Abbexa	10 ug	EUR 661.2

Cow Interleukin 1 Beta (IL1b) Protein
20-abx166303	Abbexa	EUR 895.20 EUR 360.00 EUR 2815.20 EUR 1078.80 EUR 644.40	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Interleukin 1 Beta (IL1B) Protein
20-abx261662	Abbexa	EUR 4101.60 EUR 393.60 EUR 276.00	1 mg 25 ug 5 ug

Human Interleukin 1 Beta (IL1B) Protein
20-abx261818	Abbexa	EUR 393.60 EUR 5254.80 EUR 276.00	10 ug 1 mg 2 µg

Human Interleukin 1 Beta (IL1B) Protein
20-abx261854	Abbexa	EUR 5337.60 EUR 393.60 EUR 276.00	1 mg 20 ug 5 ug

Horse Interleukin 1 Beta (IL1B) Protein
20-abx262251	Abbexa	EUR 393.60 EUR 6991.20 EUR 276.00	10 ug 1 mg 2 µg

Human Interleukin 1 Beta (IL1B) Protein
20-abx263010	Abbexa	EUR 393.60 EUR 8427.60 EUR 276.00	10 ug 1 mg 2 µg

Horse Interleukin 1 Beta (IL1b) Protein
20-abx067388	Abbexa	EUR 978.00 EUR 376.80 EUR 3082.80 EUR 1161.60 EUR 678.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Interleukin 1 Beta (IL1b) Protein
20-abx067390	Abbexa	EUR 811.20 EUR 343.20 EUR 2498.40 EUR 961.20 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Interleukin 1 Beta (IL1b) Protein
20-abx167258	Abbexa	EUR 811.20 EUR 343.20 EUR 2498.40 EUR 961.20 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Sheep Interleukin 1 Beta (IL1b) Protein
20-abx167806	Abbexa	EUR 895.20 EUR 360.00 EUR 2815.20 EUR 1078.80 EUR 644.40	100 ug 10 ug 1 mg 200 ug 50 ug

Human Interleukin 1 Beta (IL1b) Protein
20-abx651514	Abbexa	EUR 1312.80 EUR 477.60 EUR 4369.20 EUR 1596.00 EUR 895.20	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Interleukin 1 Beta (IL1b) Protein
20-abx651515	Abbexa	EUR 777.60 EUR 326.40 EUR 2331.60 EUR 910.80 EUR 560.40	100 ug 10 ug 1 mg 200 ug 50 ug

The important thing, the topical application of Cdk4 / 6 or EZH2 inhibitor on the skin is enough to completely prevent the development of psoriasis in a variety of mouse models to suppress STAT3-mediated expression of IκBζ. In addition, we found a hyperactivation of the pathway Cdk4 / 6-EZH2 in human skin lesions and psoriasis mice.