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Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines
Posted by Frank

Background: High inflammation status despite the absence of infection is known to characterize subpopulations of people with schizophrenia who suffer from more severe cognitive deficits, less gray matter cortical, and neuropathology bad. Transcripts encoding upstream factor nuclear factor kappa B (NF-kB), a major transcriptional activator for the synthesis of pro-inflammatory cytokines, increased in the frontal cortex in schizophrenia compared with controls. However, the extent of this change certain diseases, limited to people with schizophrenia and high status neuroinflammatory, or caused by the loss of key NF-kB inhibitor (HIVEP2) found in the brains of schizophrenia, has not been tested.


Methods: Post-mortem prefrontal cortex brain samples assessed in 141 men (69 controls and 72 schizophrenia) and 13 wild-type mice and the brains of mice lacking HIVEP2 (wild-type 6, 7 KO mice). gene expression of pro-inflammatory cytokines and acute phase proteins SERPINA3 used to categorize groups biotypes neuroinflammation high and low in human samples through cluster analysis. The expression of 18 genes pathway NF-kB canonical and non-canonical assessed by qPCR in human and mouse tissues.


Results: In humans, we find non-canonical upstream activator of NF-kB are generally elevated in individuals with nerve inflammation regardless of diagnosis, supports the activation of NF-kB in both controls and people with schizophrenia when high cytokine mRNA. However, patients with schizophrenia have a high neuroinflammation weaker (or not) increased transcription of several upstream activator of the canonical NF-kB as compared to control high neuroinflammation.

Decrease HIVEP2 mRNA is specialized for patients with schizophrenia who also have high neuroinflammatory status, and we also found a decrease in NF-kB transcript is usually caused by activated microglia in mice lacking HIVEP2.


Conclusion: Collectively, our results show that higher cortical expression of pro-inflammatory cytokines and lower cortical HIVEP2 expression in a subset of people with schizophrenia is associated with NF-kB transcriptional signature is relatively weak compared to non-schizophrenic controls with high cytokine expression. We speculate that the relatively mild induction of NF-kB may reflect specific emphasis schizophrenia may be associated with a deficiency HIVEP2 in the cortex.

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines
Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines


The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

Psoriasis is an inflammatory skin disease that is often characterized by hyperproliferation of keratinocytes and infiltrating immune cells related diseases. Here, we identify a novel pro-inflammatory signaling pathways driven by cyclin-dependent kinase (CDK) 4 and 6 and the methyltransferase EZH2 as a valid target for the treatment of psoriasis. Delineation of pathways revealed that Cdk4 / 6 phosphorylated EZH2 in keratinocytes, leading to methylation induced STAT3 activation.

Furthermore, the active STAT3 resulted in induction IκBζ (IkappaBzeta), which is a pro-inflammatory transcription factor that is required for the synthesis of a key cytokine in psoriasis. Pharmacological or genetic inhibition of Cdk4 / 6 or EZH2 canceled pro-inflammatory gene expression related to psoriasis-pressing IκBζ induction in keratinocytes.

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ch-96Tests 96 Tests
EUR 622

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Eq-48Tests 48 Tests
EUR 505

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Eq-96Tests 96 Tests
EUR 700

Human Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Hu-48Tests 48 Tests
EUR 302

Human Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Hu-96Tests 96 Tests
EUR 411

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Mu-48Tests 48 Tests
EUR 341

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Mu-96Tests 96 Tests
EUR 466

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-p-48Tests 48 Tests
EUR 494

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-p-96Tests 96 Tests
EUR 684

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ra-48Tests 48 Tests
EUR 358

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ra-96Tests 96 Tests
EUR 490

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Rb-48Tests 48 Tests
EUR 358

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Rb-96Tests 96 Tests
EUR 490

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-b-48T 48T
EUR 493
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-b-96T 96T
EUR 641
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-c-48T 48T
EUR 388
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-c-96T 96T
EUR 496
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ch-48T 48T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ch-96T 96T
EUR 587
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Eq-48T 48T
EUR 503
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Eq-96T 96T
EUR 654
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Hu-48T 48T
EUR 323
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Hu-96T 96T
EUR 407
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Mu-48T 48T
EUR 357
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Mu-96T 96T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-p-48T 48T
EUR 493
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-p-96T 96T
EUR 641
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ra-48T 48T
EUR 372
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ra-96T 96T
EUR 475
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Rb-48T 48T
EUR 372
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Rb-96T 96T
EUR 475
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Si-48T 48T
EUR 576
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Si-96T 96T
EUR 755
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-b-48Tests 48 Tests
EUR 516

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-b-96Tests 96 Tests
EUR 716

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-c-48Tests 48 Tests
EUR 391

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-c-96Tests 96 Tests
EUR 538

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ch-48Tests 48 Tests
EUR 470

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ch-96Tests 96 Tests
EUR 651

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Eq-48Tests 48 Tests
EUR 528

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Eq-96Tests 96 Tests
EUR 733

Human Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Hu-48Tests 48 Tests
EUR 315

Human Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Hu-96Tests 96 Tests
EUR 429

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Mu-48Tests 48 Tests
EUR 356

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Mu-96Tests 96 Tests
EUR 487

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-p-48Tests 48 Tests
EUR 516

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-p-96Tests 96 Tests
EUR 716

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ra-48Tests 48 Tests
EUR 374

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ra-96Tests 96 Tests
EUR 512

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Rb-48Tests 48 Tests
EUR 374

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Rb-96Tests 96 Tests
EUR 512

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Si-48Tests 48 Tests
EUR 614

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Si-96Tests 96 Tests
EUR 856

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Gu-48Tests 48 Tests
EUR 375

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Gu-96Tests 96 Tests
EUR 515

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Gu-48T 48T
EUR 388
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Gu-96T 96T
EUR 496
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Gu-48Tests 48 Tests
EUR 391

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Gu-96Tests 96 Tests
EUR 538

Anti-IL1 beta/Il1b Antibody

A00101-1 100ug/vial
EUR 294

Mouse Interleukin-1 beta (Il1b)

1-CSB-RP173474m
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Interleukin-1 beta(Il1b),partial expressed in E.coli

Sheep Interleukin-1 beta (IL1B)

1-CSB-YP011614SH
  • EUR 679.00
  • EUR 335.00
  • EUR 2172.00
  • EUR 1051.00
  • EUR 1442.00
  • EUR 435.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in Yeast

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Bo01
  • EUR 537.25
  • EUR 247.00
  • EUR 1739.68
  • EUR 646.56
  • EUR 1193.12
  • EUR 422.00
  • EUR 4199.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Bo02
  • EUR 537.25
  • EUR 247.00
  • EUR 1739.68
  • EUR 646.56
  • EUR 1193.12
  • EUR 422.00
  • EUR 4199.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ca01
  • EUR 548.00
  • EUR 250.00
  • EUR 1780.00
  • EUR 660.00
  • EUR 1220.00
  • EUR 430.00
  • EUR 4300.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Dog Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Eq01
  • EUR 583.84
  • EUR 259.00
  • EUR 1914.40
  • EUR 704.80
  • EUR 1309.60
  • EUR 454.00
  • EUR 4636.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Horse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Fi01
  • EUR 543.52
  • EUR 248.00
  • EUR 1763.20
  • EUR 654.40
  • EUR 1208.80
  • EUR 427.00
  • EUR 4258.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Zebrafish Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ga01
  • EUR 548.00
  • EUR 250.00
  • EUR 1780.00
  • EUR 660.00
  • EUR 1220.00
  • EUR 430.00
  • EUR 4300.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Chicken Interleukin 1 Beta expressed in: Prokaryotic expression

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Gu01
  • EUR 440.48
  • EUR 221.00
  • EUR 1376.80
  • EUR 525.60
  • EUR 951.20
  • EUR 358.00
  • EUR 3292.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Guinea pig Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Mu01
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Mu02
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ov01
  • EUR 537.25
  • EUR 247.00
  • EUR 1739.68
  • EUR 646.56
  • EUR 1193.12
  • EUR 422.00
  • EUR 4199.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Sheep Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Po01
  • EUR 512.16
  • EUR 240.00
  • EUR 1645.60
  • EUR 615.20
  • EUR 1130.40
  • EUR 406.00
  • EUR 3964.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Ra01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 1 Beta expressed in: E.coli

Recombinant Interleukin 1 Beta (IL1b)

4-RPA563Rb01
  • EUR 386.72
  • EUR 206.00
  • EUR 1175.20
  • EUR 458.40
  • EUR 816.80
  • EUR 322.00
  • EUR 2788.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rabbit Interleukin 1 Beta expressed in: E.coli

Human Interleukin-1 beta (IL1B)

1-CSB-EP011614HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli

Human Interleukin-1 beta (IL1B)

1-CSB-EP011614HUe0
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-1 beta(IL1B) expressed in E.coli

Sheep Interleukin-1 beta (IL1B)

1-CSB-EP011614SH
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Sheep Interleukin-1 beta(IL1B) expressed in E.coli

Active Interleukin 1 Beta (IL1b)

4-APA563Hu01
  • EUR 1066.78
  • EUR 389.00
  • EUR 3725.44
  • EUR 1308.48
  • EUR 2516.96
  • EUR 777.00
  • EUR 9163.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: E.coli

Active Interleukin 1 Beta (IL1b)

4-APA563Hu61
  • EUR 875.94
  • EUR 337.00
  • EUR 3009.76
  • EUR 1069.92
  • EUR 2039.84
  • EUR 649.00
  • EUR 7374.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell

Eukaryotic Interleukin 1 Beta (IL1b)

4-EPA563Hu61
  • EUR 798.88
  • EUR 317.00
  • EUR 2720.80
  • EUR 973.60
  • EUR 1847.20
  • EUR 598.00
  • EUR 6652.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 1 Beta expressed in: 293F cell

Eukaryotic Interleukin 1 Beta (IL1b)

4-EPA563Mu61
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 1 Beta expressed in: 293F cell

Interleukin 1 Beta (IL1B) Antibody

20-abx125995
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Interleukin 1 Beta (IL1B) Antibody

20-abx125996
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Interleukin 1 Beta (IL1b) Antibody

20-abx128522
  • EUR 314.00
  • EUR 133.00
  • EUR 815.00
  • EUR 425.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx129733
  • EUR 328.00
  • EUR 133.00
  • EUR 913.00
  • EUR 467.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx130423
  • EUR 467.00
  • EUR 133.00
  • EUR 1372.00
  • EUR 648.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx109931
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx109932
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx110440
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx110441
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

The important thing, the topical application of Cdk4 / 6 or EZH2 inhibitor on the skin is enough to completely prevent the development of psoriasis in a variety of mouse models to suppress STAT3-mediated expression of IκBζ. In addition, we found a hyperactivation of the pathway Cdk4 / 6-EZH2 in human skin lesions and psoriasis mice.

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