AIMS / HYPOTHESIS
inflammatory signals and increase the synthesis of prostaglandins play a role during the development of diabetes. The prostaglandin D2 (PGD2) receptor, GPR44 / DP2, is highly expressed in human islets and insulin secretion pathway activation results impaired. GPR44 activation role in the function of small islands and the survival rate for chronic hyperglycaemic conditions are unknown. In this study, we investigated GPR44 GPR44 inhibition by using a selective antagonist (AZ8154) in humans the island both in vitro and in vivo in diabetic mice transplanted with human islets.

METHOD
human islets exposed to PGD2 or proinflammatory cytokines in vitro to determine the effect of GPR44 inhibition on the survival rate of the island. In addition, the molecular mechanism of inhibition of GPR44 investigated in human islets exposed to high concentrations of glucose (HG) and IL-1β.

To the in vivo from this study, human islets are transplanted under the kidney capsule of diabetic rats immunodeficiencies and treated with 6, 60 or 100 mg / kg per day antagonist of GPR44 from the day of transplantation until day 4 short-term (studies) or study days (term long-17) post transplant. IVGTT conducted in rats at 10 days 15 days post transplant. After the termination of the study, metabolic variables, human circulating proinflammatory cytokines, and hepatocyte growth factor (HGF) were analyzed in human islets transplanted.

RESULTS
PGD2 or proinflammatory cytokine-induced apoptosis in human islets, while GPR44 inhibition of reverse these effects. GPR44 inhibition of hate decreased insulin secretion induced by glucose-stimulated HG and IL-1β in human islets. It is accompanied by activation of glycogen synthase kinase-Akt signaling 3β together with the phosphorylation and inactivation of the forkhead box O-1 and upregulation of pancreatic and duodenal homeobox-1 and HGF.

GPR44 antagonist administration up to 17 days for the diabetic mice transplanted with human islets resulted in a marginal reduction in fasting blood glucose and lower glucose fluctuations during IVGTT. improved glucose regulation is supported by an increased level of human C-peptide compared to the vehicle group on day 4 and throughout the treatment period. GPR44 inhibition reduces plasma levels of TNF-α and growth-regulated oncogene-α / chemokine (C-X-C motif) ligand 1 and raise the level of HGF in human islets.

Inhibition of GPR44 in human islets have the potential to improve the functioning of small islands and the survival rate under pressure inflammation and hyperglycaemic. This may have implications for the survival rates were better than the island after transplantation.

1 Channel Control Pannexin endothelial inflammation by regulating intracellular calcium.

The proinflammatory cytokine IL-1β is a significant risk factor in cardiovascular disease that can be targeted to reduce major cardiovascular events. expression and release of IL-1β is tightly controlled by changes in intracellular Ca2 + ([Ca2 +] i), which has been associated with the release of ATP and purinergic signaling. However, the mechanisms that regulate these changes have not been identified.

Interleukin 8 (IL8) Antibody
20-abx270201	Abbexa	EUR 560.40 EUR 644.40 EUR 326.40 EUR 978.00 EUR 427.20	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody
20-abx173191	Abbexa	EUR 427.20 EUR 1095.60 EUR 560.40 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx177199	Abbexa	EUR 427.20 EUR 159.60 EUR 1245.60 EUR 627.60 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx177201	Abbexa	EUR 1429.20 EUR 693.60	1 mg 200 ug

Interleukin 8 (IL8) Antibody
abx216289-100ug	Abbexa	100 ug	EUR 526.8

Interleukin 8 (IL8) Antibody
abx020956-05mg	Abbexa	0.5 mg	EUR 1296

Interleukin 8 (IL8) Antibody
abx018002-100ug	Abbexa	100 ug	EUR 410.4

Interleukin 8 (IL8) Antibody
abx036426-100ug	Abbexa	100 ug	EUR 469.2

Interleukin 8 (IL8) Antibody
20-abx100960	Abbexa	EUR 376.80 EUR 159.60 EUR 994.80 EUR 510.00 EUR 326.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100961	Abbexa	EUR 493.20 EUR 159.60 EUR 1345.20 EUR 661.20 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100962	Abbexa	EUR 493.20 EUR 159.60 EUR 1345.20 EUR 661.20 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100963	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100964	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100965	Abbexa	EUR 477.60 EUR 159.60 EUR 1279.20 EUR 627.60 EUR 360.00	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100966	Abbexa	EUR 376.80 EUR 927.60 EUR 493.20 EUR 184.80 EUR 309.60	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100967	Abbexa	EUR 493.20 EUR 159.60 EUR 1395.60 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100969	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100970	Abbexa	EUR 410.40 EUR 1045.20 EUR 543.60 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100971	Abbexa	EUR 543.60 EUR 159.60 EUR 1579.20 EUR 760.80 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx100972	Abbexa	EUR 560.40 EUR 159.60 EUR 1646.40 EUR 777.60 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131832	Abbexa	EUR 427.20 EUR 1111.20 EUR 560.40 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131833	Abbexa	EUR 410.40 EUR 1045.20 EUR 543.60 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131834	Abbexa	EUR 393.60 EUR 994.80 EUR 510.00 EUR 184.80 EUR 309.60	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131835	Abbexa	EUR 393.60 EUR 1011.60 EUR 526.80 EUR 184.80 EUR 309.60	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131836	Abbexa	EUR 410.40 EUR 1045.20 EUR 543.60 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131837	Abbexa	EUR 410.40 EUR 1045.20 EUR 543.60 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131838	Abbexa	EUR 360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131839	Abbexa	EUR 393.60 EUR 994.80 EUR 510.00 EUR 184.80 EUR 309.60	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx131840	Abbexa	EUR 393.60 EUR 994.80 EUR 510.00 EUR 184.80 EUR 309.60	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 (IL8) Antibody
20-abx009111	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Dog Interleukin-8 (IL8)
1-CSB-YP011671DO	Cusabio	EUR 814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Dog Interleukin-8(IL8) expressed in Yeast

Dog Interleukin-8 (IL8)
1-CSB-EP011671DO	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Dog Interleukin-8(IL8) expressed in E.coli

Dog Interleukin-8 (IL8)
1-CSB-MP011671DO	Cusabio	EUR 351.60 EUR 1155.60 EUR 490.80 EUR 860.40	100ug 1MG 200ug 500ug
Description: Recombinant Dog Interleukin-8(IL8) expressed in Mammalian cell

Active Interleukin 8 (IL8)
4-APA080Hu01	Cloud-Clone	EUR 700.61 EUR 310.80 EUR 2297.28 EUR 845.76 EUR 1571.52 EUR 544.80 EUR 5563.20	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 8 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Sheep Interleukin-8 (IL8)
1-CSB-EP011671SH	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Sheep Interleukin-8(IL8) expressed in E.coli

Active Interleukin 8 (IL8)
RPU59242-100ug	Biomatik Corporation	100ug	EUR 1140.2

Active Interleukin 8 (IL8)
RPU59242-1mg	Biomatik Corporation	1mg	EUR 5054.4

Active Interleukin 8 (IL8)
RPU59242-50ug	Biomatik Corporation	50ug	EUR 760.3

Active Interleukin 8 (IL8)
RPU55475-100ug	Biomatik Corporation	100ug	EUR 453.2

Active Interleukin 8 (IL8)
RPU55475-1mg	Biomatik Corporation	1mg	EUR 2009.8

Active Interleukin 8 (IL8)
RPU55475-50ug	Biomatik Corporation	50ug	EUR 364.1

Interleukin 8 (IL8) Antibody (PE)
20-abx270865	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (PE)
20-abx270914	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (PE)
20-abx270962	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (PE)
20-abx270963	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (PE)
20-abx274631	Abbexa	EUR 477.60 EUR 260.40 EUR 1161.60 EUR 594.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Eukaryotic Interleukin 8 (IL8)
4-EPA080Bo61	Cloud-Clone	EUR 571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Interleukin 8 expressed in: 293F cell

Eukaryotic Interleukin 8 (IL8)
RPU52379-100ug	Biomatik Corporation	100ug	EUR 517

Eukaryotic Interleukin 8 (IL8)
RPU52379-1mg	Biomatik Corporation	1mg	EUR 2293.2

Eukaryotic Interleukin 8 (IL8)
RPU52379-50ug	Biomatik Corporation	50ug	EUR 415.8

Interleukin 8 (IL8) Antibody (APC)
20-abx270633	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (APC)
20-abx270682	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (APC)
20-abx270730	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (APC)
20-abx270731	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (APC)
20-abx177200	Abbexa	EUR 1412.40 EUR 693.60	1 mg 200 ug

Recombinant Interleukin 8 (IL8)
4-RPA080Ca01	Cloud-Clone	EUR 528.58 EUR 265.20 EUR 1652.16 EUR 630.72 EUR 1141.44 EUR 429.60 EUR 3950.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Dog Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Eq01	Cloud-Clone	EUR 603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Horse Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Ga01	Cloud-Clone	EUR 636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Chicken Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Gu01	Cloud-Clone	EUR 571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Guinea pig Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Hu01	Cloud-Clone	EUR 442.56 EUR 242.40 EUR 1329.60 EUR 523.20 EUR 926.40 EUR 372.00 EUR 3144.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Ov01	Cloud-Clone	EUR 657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Sheep Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Po01	Cloud-Clone	EUR 636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pig Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Rb01	Cloud-Clone	EUR 636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rabbit Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
4-RPA080Si01	Cloud-Clone	EUR 636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Simian Interleukin 8 expressed in: E.coli

Recombinant Interleukin 8 (IL8)
RPU42325-100ug	Biomatik Corporation	100ug	EUR 468.6

Recombinant Interleukin 8 (IL8)
RPU42325-1mg	Biomatik Corporation	1mg	EUR 2074.8

Recombinant Interleukin 8 (IL8)
RPU42325-50ug	Biomatik Corporation	50ug	EUR 376.2

Recombinant Interleukin 8 (IL8)
RPU42326-100ug	Biomatik Corporation	100ug	EUR 554.4

Recombinant Interleukin 8 (IL8)
RPU42326-1mg	Biomatik Corporation	1mg	EUR 2457

Recombinant Interleukin 8 (IL8)
RPU42326-50ug	Biomatik Corporation	50ug	EUR 445.5

Recombinant Interleukin 8 (IL8)
RPU42327-100ug	Biomatik Corporation	100ug	EUR 591.8

Recombinant Interleukin 8 (IL8)
RPU42327-1mg	Biomatik Corporation	1mg	EUR 2620.8

Recombinant Interleukin 8 (IL8)
RPU42327-50ug	Biomatik Corporation	50ug	EUR 475.2

Recombinant Interleukin 8 (IL8)
RPU42328-100ug	Biomatik Corporation	100ug	EUR 517

Recombinant Interleukin 8 (IL8)
RPU42328-1mg	Biomatik Corporation	1mg	EUR 2293.2

Recombinant Interleukin 8 (IL8)
RPU42328-50ug	Biomatik Corporation	50ug	EUR 415.8

Recombinant Interleukin 8 (IL8)
RPU42329-100ug	Biomatik Corporation	100ug	EUR 369.6

Recombinant Interleukin 8 (IL8)
RPU42329-1mg	Biomatik Corporation	1mg	EUR 1638

Recombinant Interleukin 8 (IL8)
RPU42329-50ug	Biomatik Corporation	50ug	EUR 297

Recombinant Interleukin 8 (IL8)
RPU42330-100ug	Biomatik Corporation	100ug	EUR 591.8

Recombinant Interleukin 8 (IL8)
RPU42330-1mg	Biomatik Corporation	1mg	EUR 2620.8

Recombinant Interleukin 8 (IL8)
RPU42330-50ug	Biomatik Corporation	50ug	EUR 475.2

Recombinant Interleukin 8 (IL8)
RPU42331-100ug	Biomatik Corporation	100ug	EUR 591.8

Recombinant Interleukin 8 (IL8)
RPU42331-1mg	Biomatik Corporation	1mg	EUR 2620.8

Recombinant Interleukin 8 (IL8)
RPU42331-50ug	Biomatik Corporation	50ug	EUR 475.2

Recombinant Interleukin 8 (IL8)
RPU42332-100ug	Biomatik Corporation	100ug	EUR 591.8

Recombinant Interleukin 8 (IL8)
RPU42332-1mg	Biomatik Corporation	1mg	EUR 2620.8

Recombinant Interleukin 8 (IL8)
RPU42332-50ug	Biomatik Corporation	50ug	EUR 475.2

Recombinant Interleukin 8 (IL8)
RPU42333-100ug	Biomatik Corporation	100ug	EUR 616

Recombinant Interleukin 8 (IL8)
RPU42333-1mg	Biomatik Corporation	1mg	EUR 2730

Recombinant Interleukin 8 (IL8)
RPU42333-50ug	Biomatik Corporation	50ug	EUR 495

Recombinant Interleukin 8 (IL8)
RPU58416-100ug	Biomatik Corporation	100ug	EUR 551.1

Recombinant Interleukin 8 (IL8)
RPU58416-1mg	Biomatik Corporation	1mg	EUR 2558.4

Recombinant Interleukin 8 (IL8)
RPU58416-50ug	Biomatik Corporation	50ug	EUR 428.5

Recombinant Interleukin 8 (IL8)
RPU58417-100ug	Biomatik Corporation	100ug	EUR 551.1

Recombinant Interleukin 8 (IL8)
RPU58417-1mg	Biomatik Corporation	1mg	EUR 2558.4

Recombinant Interleukin 8 (IL8)
RPU58417-50ug	Biomatik Corporation	50ug	EUR 428.5

Interleukin 8 (IL8) Antibody (FITC)
20-abx270401	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (FITC)
20-abx270450	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (FITC)
20-abx270498	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (FITC)
20-abx270499	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 8 (IL8) Antibody (FITC)
20-abx271013	Abbexa	EUR 393.60 EUR 243.60 EUR 978.00 EUR 510.00 EUR 343.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody Pair
abx117314-1pair5x96wellplates	Abbexa	1 pair (5x96 well plates)	EUR 1212

Interleukin 8 (IL8) Antibody Pair
20-abx370066	Abbexa	EUR 1412.40 EUR 927.60	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370068	Abbexa	EUR 2397.60 EUR 1513.20	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370095	Abbexa	EUR 1446.00 EUR 944.40	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370128	Abbexa	EUR 2047.20 EUR 1312.80	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370248	Abbexa	EUR 1412.40 EUR 927.60	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370249	Abbexa	EUR 1796.40 EUR 1161.60	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370251	Abbexa	EUR 1846.80 EUR 1195.20	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370256	Abbexa	EUR 2148.00 EUR 1362.00	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370625	Abbexa	EUR 1713.60 EUR 1111.20	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody Pair
20-abx370655	Abbexa	EUR 2298.00 EUR 1462.80	10 × 96 tests 5 × 96 tests

Interleukin 8 (IL8) Antibody (FITC)
20-abx273525	Abbexa	EUR 410.40 EUR 260.40 EUR 1161.60 EUR 577.20 EUR 343.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody (FITC)
20-abx273530	Abbexa	EUR 493.20 EUR 276.00 EUR 1395.60 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody (FITC)
20-abx273545	Abbexa	EUR 526.80 EUR 292.80 EUR 1496.40 EUR 727.20 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody (FITC)
20-abx274200	Abbexa	EUR 560.40 EUR 292.80 EUR 1646.40 EUR 777.60 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 (IL8) Antibody (FITC)
20-abx273851	Abbexa	EUR 410.40 EUR 260.40 EUR 1178.40 EUR 594.00 EUR 343.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 8 / IL8 (CXCL8) Antibody
20-abx317929	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 / IL8 (CXCL8) Antibody
abx200558-100ug	Abbexa	100 ug	EUR 543.6

Interleukin 8 / IL8 (CXCL8) Antibody
20-abx210112	Abbexa	EUR 526.80 EUR 393.60	100 ug 50 ug

Interleukin 8 / IL8 (CXCL8) Antibody
20-abx109944	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 / IL8 (CXCL8) Antibody
20-abx110542	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 / IL8 (CXCL8) Antibody
20-abx110581	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 8 / IL8 (CXCL8) Antibody
20-abx113257	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Interleukin 8 / IL8 (CXCL8) Antibody
abx034024-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 8 / IL8 (CXCL8) Antibody
abx034024-80l	Abbexa	80 µl	EUR 343.2

Interleukin 8 / IL8 (CXCL8) Antibody
20-abx100968	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

The pannexin 1 (Panx1) channel has been canonically been involved in the ATP release, particularly during inflammation. We checked Panx1 in human umbilical vein endothelial cells after treatment with proinflammatory cytokines TNF-α. Analysis by the whole transcriptome sequencing and immunoblot Panx1 identified a dramatic increase in mRNA and protein expression were regulated by NF-kB-dependent.