Transcription factor nuclear factor kappa B (NF-kB) regulates the expression of many inflammatory genes are expressed in a subset of people with schizophrenia. reduction in the transcription of NF-kB inhibitors, Human Immunodeficiency Virus Enhancer Binding Protein 2 (HIVEP2), found in the brains of patients, aligning with NF-kB evidence of over-activity. HIVEP2 cellular co-expression and cytokine transcripts is a prerequisite for the direct effect of HIVEP2 the pro-inflammatory transcription, and we do not know whether the change HIVEP2 and markers of neuroinflammation that occur in the same type of brain cell.
We conducted in situ hybridization in the dorsolateral prefrontal cortex postmortem tissue to map and compare the expression HIVEP2 and serpin Family Member 3 (SERPINA3), one of the most consistently increased inflammatory gene in schizophrenia, among patients with schizophrenia and control.
We found that the expression HIVEP2 are neurons and decreased in almost all layers of gray matter cortex in schizophrenic patients with neuroinflammation, and that SERPINA3 increased in the dorsolateral prefrontal cortex gray matter and white matter in the same group of patients. We were the first to map the upregulation SERPINA3 for astrocytes and some neurons, and found evidence that the blood vessel-associated astrocyte is the major cellular source SERPINA3 in the cortex of schizophrenia.
We show that the lack of HIVEP2 in rats does not lead to upregulation of astrocytic of Serpina3n but did not induce transcription in neurons. We speculate that downregulation HIVEP2 not a direct cause of the synthesis of pro-inflammatory cytokines astrocytic in schizophrenia but can cause nerve inflammation-mediated neuronally.

Protocatechuic aldehyde weaken UVA-Induced Photoaging in Human Dermal Fibroblast Cells by Suppressing Aftershave MAPKs / AP-1 and NF-kB Signaling Pathways
Obesity is a significant breast cancer (BC) risk factors and is associated with a 20-40% increased risk in obese postmenopausal women compared with their lean counterparts. Some metabolic dysregulations associated with obesity has been associated with the risk of SM, including the overactivation of the renin-angiotensin system (RAS).
Currently, the RAS inhibitors, including angiotensin converting enzyme inhibitors (ACEI) and AT1 receptor blockers (ARB), is used as an anti-hypertensive therapy is safe and effective in patients with SM. However, it is uncertain how the inhibition of the RAS in adipose tissue impact of obesity-BC crosstalk.
We hypothesize that inhibition of adipose RAS will reduce BCE cell motility and inflammation. We determined (1) the direct effect of Ang II, ACEI (captopril; Cap) or ARB (telmisartan; Tel) on MCF-7 receptor-positive and triple receptor-negative MDA-MB-231 cells; and (2) the effects of conditioned media (CM) of human mesenchymal stem cells differentiated into adipocytes, pre-treatment with RAS inhibitors, the cells BC.
We show that the direct treatment of cells with Ang II SM, Cap or Phone does not alter either the inflammatory cytokine BC cell lines. CM of adipocytes Ang II-pre-treatment significantly increases the secretion of pro-inflammatory markers at the protein level. RAS inhibitors reduce their secretion in MDA-MB-231, but not in MCF-7 cells.
Interleukin 1 Alpha (IL1a) Antibody |
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20-abx104904 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101891 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101892 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173020 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173021 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173022 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173023 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173024 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177052 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177054 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177055 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx210848 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx211106 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx132312 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx326469 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx113230 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx018000-100ug | Abbexa | 100 ug | EUR 460.8 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx036412-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101885 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101886 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101887 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx101888 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101889 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101890 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx128132 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129396 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129503 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131946 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131947 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131948 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131949 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131950 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131951 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx001782 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx011004-100ul | Abbexa | 100 ul | EUR 493.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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20-abx300512 | Abbexa |
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Interleukin-1 Alpha (IL1A) Antibody |
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20-abx225241 | Abbexa |
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Active Interleukin 1 Alpha (IL1a) |
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4-APA071Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-RP065654h | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-RP065694h | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-YP011613HUc7 | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in Yeast |
Interleukin 1 Alpha (IL1a) Antibody (APC) |
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20-abx177053 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (HRP) |
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20-abx108418 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (HRP) |
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20-abx300513 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (FITC) |
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20-abx106997 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody Pair |
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abx117488-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370238 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370358 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370543 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370642 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370733 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (FITC) |
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20-abx273853 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (FITC) |
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20-abx300514 | Abbexa |
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Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ca01 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ca02 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Cp01 | Cloud-Clone |
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Description: Recombinant Goat Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Eq01 | Cloud-Clone |
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Description: Recombinant Horse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Gu01 | Cloud-Clone |
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Description: Recombinant Guinea pig Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Hu02 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Po01 | Cloud-Clone |
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Description: Recombinant Pig Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ra01 | Cloud-Clone |
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Description: Recombinant Rat Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Rb01 | Cloud-Clone |
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Description: Recombinant Rabbit Interleukin 1 Alpha expressed in: E.coli |
Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271654 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271680 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271733 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271911 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (Biotin) |
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20-abx105579 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273056 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273137 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273464 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274415 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274447 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274500 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274526 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (Biotin) |
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20-abx300515 | Abbexa |
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Interleukin-1 Alpha (IL1A-S87) Antibody |
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abx033026-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin-1 Alpha (IL1A-S87) Antibody |
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abx033026-80l | Abbexa | 80 µl | EUR 343.2 |
Rat Interleukin 1 Alpha (IL1A) Protein |
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20-abx262243 | Abbexa |
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Pig Interleukin 1 Alpha (IL1A) Protein |
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20-abx263471 | Abbexa |
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Dog Interleukin 1 Alpha (IL1a) Protein |
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20-abx067380 | Abbexa |
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Pig Interleukin 1 Alpha (IL1a) Protein |
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20-abx067385 | Abbexa |
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Cow Interleukin 1 Alpha (IL1a) Protein |
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20-abx069738 | Abbexa |
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Rat Interleukin 1 Alpha (IL1a) Protein |
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20-abx069739 | Abbexa |
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Cow Interleukin 1 Alpha (IL1A) Protein |
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abx670140-5ug | Abbexa | 5 ug | EUR 493.2 |
Dog Interleukin 1 Alpha (IL1a) Protein |
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20-abx166352 | Abbexa |
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Horse Interleukin 1 Alpha (IL1a) ELISA |
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QY-E120051 | Qayee Biotechnology | 96T | EUR 573.6 |
Goat Interleukin 1 Alpha (IL1a) Protein |
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20-abx067381 | Abbexa |
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Human Interleukin 1 Alpha (IL1A) Protein |
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20-abx262129 | Abbexa |
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Human Interleukin 1 Alpha (IL1A) Protein |
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20-abx262231 | Abbexa |
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Mouse Interleukin 1 Alpha (IL1A) Protein |
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20-abx262259 | Abbexa |
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Horse Interleukin 1 Alpha (IL1a) Protein |
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20-abx067382 | Abbexa |
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Human Interleukin 1 Alpha (IL1a) Protein |
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20-abx067384 | Abbexa |
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Mouse Interleukin 1 Alpha (IL1a) Protein |
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20-abx167384 | Abbexa |
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Mouse Interleukin 1 Alpha (IL1a) Protein |
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20-abx167394 | Abbexa |
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Sheep Interleukin 1 Alpha (IL1a) Protein |
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20-abx653926 | Abbexa |
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Human Interleukin 1 Alpha (IL1a) Protein |
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20-abx166463 | Abbexa |
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Monkey Interleukin 1 Alpha (IL1A) Protein |
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20-abx262272 | Abbexa |
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Rabbit Interleukin 1 Alpha (IL1a) Protein |
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20-abx067386 | Abbexa |
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Rabbit Interleukin 1 Alpha (IL1A) Protein |
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abx670325-5ug | Abbexa | 5 ug | EUR 493.2 |
Macaca mulatta Interleukin-1 alpha (IL1A) |
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1-CSB-YP011613MOW | Cusabio |
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Description: Recombinant Macaca mulatta Interleukin-1 alpha(IL1A) expressed in Yeast |
Rat Interleukin 1 Alpha (IL1a) CLIA Kit |
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20-abx490663 | Abbexa |
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Cow Interleukin 1 Alpha (IL1a) CLIA Kit |
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20-abx490909 | Abbexa |
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Dog Interleukin 1 Alpha (IL1a) CLIA Kit |
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20-abx490910 | Abbexa |
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Pig Interleukin 1 Alpha (IL1a) CLIA Kit |
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20-abx490916 | Abbexa |
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Rat Interleukin 1 Alpha (IL1a) CLIA Kit |
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20-abx490917 | Abbexa |
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Pig Interleukin 1 Alpha (IL1A) ELISA Kit |
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abx255507-96tests | Abbexa | 96 tests | EUR 904.8 |
Rat Interleukin 1 Alpha (IL1a) ELISA Kit |
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abx255760-96tests | Abbexa | 96 tests | EUR 895.2 |
Dog Interleukin 1 Alpha (IL1A) ELISA Kit |
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abx257592-96tests | Abbexa | 96 tests | EUR 1036.8 |
Pig Interleukin 1 Alpha (IL1a) ELISA Kit |
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20-abx154954 | Abbexa |
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Rat Interleukin 1 Alpha (IL1a) ELISA Kit |
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20-abx155712 | Abbexa |
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Cow Interleukin 1 Alpha (IL1a) ELISA Kit |
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20-abx150141 | Abbexa |
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Dog Interleukin 1 Alpha (IL1a) ELISA Kit |
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20-abx150257 | Abbexa |
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Goat Interleukin 1 Alpha (IL1a) CLIA Kit |
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20-abx490661 | Abbexa |
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Rat Interleukin 1 Alpha (IL1A) ELISA Kit |
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abx050109-96tests | Abbexa | 96 tests | EUR 745.2 |
Goat Interleukin 1 Alpha (IL1a) CLIA Kit |
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20-abx496550 | Abbexa |
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Rat Interleukin 1 Alpha (IL1a) ELISA Kit |
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abx574551-96tests | Abbexa | 96 tests | EUR 895.2 |
Dog Interleukin 1 Alpha (IL1A) ELISA Kit |
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abx574788-96tests | Abbexa | 96 tests | EUR 1036.8 |
Cow Interleukin 1 Alpha (IL1a) ELISA Kit |
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abx574892-96tests | Abbexa | 96 tests | EUR 1093.2 |
Rat Interleukin 1 Alpha (IL1a) ELISA Kit |
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DLR-IL1a-Ra-48T | DL Develop | 48T | EUR 387.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Interleukin 1 Alpha (IL1a) ELISA Kit |
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DLR-IL1a-Ra-96T | DL Develop | 96T | EUR 488.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
In addition, the CM of adipocytes treated with RAS inhibitors significantly reduces markers of inflammation, fat synthesis, and angiogenesis in both cell lines BC. In addition, the CM of ACEI pretreated adipocytes was reduced motility in both cell lines BC. The findings of our study indicate the important role of RAS inhibition in adipocytes and adipose cell crosstalk BC.