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Autophagy modulation altered differentiation capacity of CD146+ cells toward endothelial cells, pericytes, and cardiomyocytes.

Autophagy modulation altered differentiation capacity of CD146+ cells toward endothelial cells, pericytes, and cardiomyocytes.
Posted by Frank

BACKGROUND
Until now, a lot of effort used to enhance the regenerative potential of stem cells. In this study, we evaluated the hypothesis whether the modulation of autophagy could change differentiation potential of CD146 + cells into mature pericytes, endothelium, and cardiomyocytes descent.


METHOD
In this study, CD146 + cells enriched from human bone marrow aspiration and trans-differentiated into mature endothelial cells, pericytes, and cardiomyocytes after exposure autophagy stimulator (50 pM Met) / inhibitor (15-pM HCQ). Protein autophagy protein levels are monitored by western blotting.

NO content measured using the Griess test. Using real-time PCR assay and western blotting, we monitor the rate of descent of proteins and genes. Pro-inflammatory cytokines and angiocrine factors were measured by ELISA. Changes in fatty acids determined by gas chromatography. We also measure exosome secretion capacity by measuring the activity of AChE and real-time PCR.


RESULTS
Data revealed the factors modulating autophagy, Beclin-1, P62, and the ratio of LC3-II / I in CD146 + cells differentiate after exposure to the Met and HCQ (p <0.05). Inhibition of autophagy increased NO content compared with Met-treated cells (p <0.05). Real-time PCR analysis showed that treatment with CD146 + cells autophagy modulators alter expression of VE-cadherin, cTnI, and α-SMA (p <0.05). Met increasing the expression of VE-cadherin, α-SMA, and cTnI compared to HCQ-treated cells (p <0.05), while western blotting revealed the protein synthesis of all proteins specific line under the stimulation and inhibition of autophagy.

No statistically significant difference was found in levels of Tie-1, Tie-2, VEGFR-1 and VEGFR-2 after autophagy modulation. Fatty acid profile analysis revealed an increase in polyunsaturated fatty acids after exposure HCQ (p <0.05). Treatment of cells with HCQ increase levels of TNF-α and IL-6 compared with Met-treated cells. The data revealed an increase exosome biogenesis and secretion to the supernatant in cells treated with HCQ compared with Met group (p <0.05).


CONCLUSION
In short, the modulation of autophagy could change differentiation potential of CD146 + cells that are important in cardiac regeneration.

Autophagy modulation altered differentiation capacity of CD146+ cells toward endothelial cells, pericytes, and cardiomyocytes.
Autophagy modulation altered differentiation capacity of CD146+ cells toward endothelial cells, pericytes, and cardiomyocytes.

Iron Deprivation in Human T Cells Induces Nonproliferating Accessories Helper Sel.

Iron uptake via the transferrin receptor (CD71) is an important mechanism for the proliferation of T cells, however, it is not fully understood if targeting CD71 also affect the differentiation and functional polarization of primary human T cells.

In this study, we demonstrated that inhibition of iron consumption by blocking nonproliferating CD71 mAbs to induce T cell, which releases high amounts of IL-2. The target of CD71 by blocking or nonblocking mAbs did not alter the main signal path and the activation of the transcription factor NF-kB, NFAT, or AP-1 as analyzed in Jurkat T cell growth arrest in T cells were deficient in iron (Fe-def) prevented after the addition of exogenous iron in the form of ferric ammonium citrate but not reversible by exogenous IL-2.

Interleukin 6 (IL6) Antibody

abx036477-100ug 100 ug
EUR 469.2

Bovine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-b-48T 48T
EUR 591.6
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-b-96T 96T
EUR 769.2
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-c-48T 48T
EUR 568.8
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-c-96T 96T
EUR 736.8
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Ch-48T 48T
EUR 544.8
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Ch-96T 96T
EUR 704.4
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Eq-48T 48T
EUR 603.6
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Eq-96T 96T
EUR 784.8
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Goat Interleukin 6 (IL6) ELISA Kit

DLR-IL6-g-48T 48T
EUR 547.2
Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Goat Interleukin 6 (IL6) ELISA Kit

DLR-IL6-g-96T 96T
EUR 708
Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Hu-48T 48T
EUR 420
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Hu-96T 96T
EUR 532.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Mu-48T 48T
EUR 428.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Mu-96T 96T
EUR 544.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-p-48T 48T
EUR 591.6
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 6 (IL6) ELISA Kit

DLR-IL6-p-96T 96T
EUR 769.2
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Ra-48T 48T
EUR 446.4
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Ra-96T 96T
EUR 570
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Rb-48T 48T
EUR 544.8
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Rb-96T 96T
EUR 704.4
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Sheep Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Sh-48T 48T
EUR 626.4
Description: A sandwich quantitative ELISA assay kit for detection of Sheep Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Sheep Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Sh-96T 96T
EUR 817.2
Description: A sandwich quantitative ELISA assay kit for detection of Sheep Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Si-48T 48T
EUR 626.4
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 6 (IL6) ELISA Kit

DLR-IL6-Si-96T 96T
EUR 817.2
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 6 (IL6) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 6 (IL6) ELISA Kit

RD-IL6-b-48Tests 48 Tests
EUR 592.8

Bovine Interleukin 6 (IL6) ELISA Kit

RD-IL6-b-96Tests 96 Tests
EUR 820.8

Canine Interleukin 6 (IL6) ELISA Kit

RD-IL6-c-48Tests 48 Tests
EUR 566.4

Canine Interleukin 6 (IL6) ELISA Kit

RD-IL6-c-96Tests 96 Tests
EUR 783.6

Chicken Interleukin 6 (IL6) ELISA Kit

RD-IL6-Ch-48Tests 48 Tests
EUR 540

Chicken Interleukin 6 (IL6) ELISA Kit

RD-IL6-Ch-96Tests 96 Tests
EUR 746.4

Equine Interleukin 6 (IL6) ELISA Kit

RD-IL6-Eq-48Tests 48 Tests
EUR 606

Equine Interleukin 6 (IL6) ELISA Kit

RD-IL6-Eq-96Tests 96 Tests
EUR 840

Goat Interleukin 6 (IL6) ELISA Kit

RD-IL6-g-48Tests 48 Tests
EUR 543.6

Goat Interleukin 6 (IL6) ELISA Kit

RD-IL6-g-96Tests 96 Tests
EUR 750

Human Interleukin 6 (IL6) ELISA Kit

RD-IL6-Hu-48Tests 48 Tests
EUR 399.6

Human Interleukin 6 (IL6) ELISA Kit

RD-IL6-Hu-96Tests 96 Tests
EUR 544.8

Mouse Interleukin 6 (IL6) ELISA Kit

RD-IL6-Mu-48Tests 48 Tests
EUR 409.2

Mouse Interleukin 6 (IL6) ELISA Kit

RD-IL6-Mu-96Tests 96 Tests
EUR 559.2

Porcine Interleukin 6 (IL6) ELISA Kit

RD-IL6-p-48Tests 48 Tests
EUR 592.8

Porcine Interleukin 6 (IL6) ELISA Kit

RD-IL6-p-96Tests 96 Tests
EUR 820.8

Rat Interleukin 6 (IL6) ELISA Kit

RD-IL6-Ra-48Tests 48 Tests
EUR 429.6

Rat Interleukin 6 (IL6) ELISA Kit

RD-IL6-Ra-96Tests 96 Tests
EUR 588

Rabbit Interleukin 6 (IL6) ELISA Kit

RD-IL6-Rb-48Tests 48 Tests
EUR 540

Rabbit Interleukin 6 (IL6) ELISA Kit

RD-IL6-Rb-96Tests 96 Tests
EUR 746.4

Sheep Interleukin 6 (IL6) ELISA Kit

RD-IL6-Sh-48Tests 48 Tests
EUR 632.4

Sheep Interleukin 6 (IL6) ELISA Kit

RD-IL6-Sh-96Tests 96 Tests
EUR 877.2

Monkey Interleukin 6 (IL6) ELISA Kit

RD-IL6-Si-48Tests 48 Tests
EUR 632.4

Monkey Interleukin 6 (IL6) ELISA Kit

RD-IL6-Si-96Tests 96 Tests
EUR 877.2

Bovine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-b-48Tests 48 Tests
EUR 619.2

Bovine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-b-96Tests 96 Tests
EUR 859.2

Canine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-c-48Tests 48 Tests
EUR 591.6

Canine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-c-96Tests 96 Tests
EUR 819.6

Chicken Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Ch-48Tests 48 Tests
EUR 564

Chicken Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Ch-96Tests 96 Tests
EUR 781.2

Equine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Eq-48Tests 48 Tests
EUR 633.6

Equine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Eq-96Tests 96 Tests
EUR 879.6

Goat Interleukin 6 (IL6) ELISA Kit

RDR-IL6-g-48Tests 48 Tests
EUR 567.6

Goat Interleukin 6 (IL6) ELISA Kit

RDR-IL6-g-96Tests 96 Tests
EUR 784.8

Human Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Hu-48Tests 48 Tests
EUR 416.4

Human Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Hu-96Tests 96 Tests
EUR 568.8

Mouse Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Mu-48Tests 48 Tests
EUR 427.2

Mouse Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Mu-96Tests 96 Tests
EUR 584.4

Porcine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-p-48Tests 48 Tests
EUR 619.2

Porcine Interleukin 6 (IL6) ELISA Kit

RDR-IL6-p-96Tests 96 Tests
EUR 859.2

Rat Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Ra-48Tests 48 Tests
EUR 448.8

Rat Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Ra-96Tests 96 Tests
EUR 614.4

Rabbit Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Rb-48Tests 48 Tests
EUR 564

Rabbit Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Rb-96Tests 96 Tests
EUR 781.2

Sheep Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Sh-48Tests 48 Tests
EUR 661.2

Sheep Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Sh-96Tests 96 Tests
EUR 918

Monkey Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Si-48Tests 48 Tests
EUR 661.2

Monkey Interleukin 6 (IL6) ELISA Kit

RDR-IL6-Si-96Tests 96 Tests
EUR 918

Recombinant Human IL6/ Interleukin 6 Protein, Native, Human-100ug

QDX53-100ug 100ug
EUR 738

Recombinant Mouse IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP1487-100ug 100ug
EUR 729.6

Recombinant Human IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP5235-100ug 100ug
EUR 588

Recombinant Rat IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP5501-100ug 100ug
EUR 849.6

Human Interleukin 6 (IL6) Protein

abx060189-100ug 100 ug
EUR 627.6

Human Interleukin 6 (IL6) Protein

abx060253-100ug 100 ug
EUR 627.6

Recombinant Human IL6/ Interleukin-6 Protein Protein, Untagged, E.coli-100ug

QP10313-ec-100ug 100ug
EUR 1185.6

Recombinant Mouse IL6/ Interleukin-6 Protein Protein, Untagged, E.coli-100ug

QP10455-ec-100ug 100ug
EUR 1185.6

Recombinant Macaque IL6/ Interleukin-6 Protein Protein, Untagged, E.coli-100ug

QP1556-ec-100ug 100ug
EUR 2013.6

Recombinant Sheep IL6/ Interleukin-6 Protein Protein, GST, E.coli-100ug

QP6225-ec-100ug 100ug
EUR 848.4

Recombinant Sheep IL6/ Interleukin-6 Protein Protein, His, Yeast-100ug

QP6225-ye-100ug 100ug
EUR 945.6

Recombinant Rabbit IL6/ Interleukin-6 Protein Protein, His, Yeast-100ug

QP9889-ye-100ug 100ug
EUR 945.6

Interleukin 6 (IL6) Antibody

20-abx210132
  • EUR 526.80
  • EUR 393.60
  • 100 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx323731
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100949
  • EUR 393.60
  • EUR 159.60
  • EUR 1078.80
  • EUR 543.60
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100950
  • EUR 326.40
  • EUR 159.60
  • EUR 760.80
  • EUR 393.60
  • EUR 292.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100951
  • EUR 410.40
  • EUR 159.60
  • EUR 1144.80
  • EUR 577.20
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100952
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100953
  • EUR 510.00
  • EUR 159.60
  • EUR 1429.20
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100954
  • EUR 543.60
  • EUR 159.60
  • EUR 1545.60
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100956
  • EUR 393.60
  • EUR 159.60
  • EUR 1111.20
  • EUR 560.40
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100957
  • EUR 560.40
  • EUR 159.60
  • EUR 1646.40
  • EUR 777.60
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx100958
  • EUR 427.20
  • EUR 1144.80
  • EUR 577.20
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx109943
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx104905
  • EUR 376.80
  • EUR 159.60
  • EUR 994.80
  • EUR 526.80
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx173179
  • EUR 360.00
  • EUR 844.80
  • EUR 427.20
  • EUR 184.80
  • EUR 292.80
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx173183
  • EUR 427.20
  • EUR 1095.60
  • EUR 560.40
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx132326
  • EUR 410.40
  • EUR 1045.20
  • EUR 543.60
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131321
  • EUR 393.60
  • EUR 159.60
  • EUR 1078.80
  • EUR 543.60
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131322
  • EUR 543.60
  • EUR 159.60
  • EUR 1545.60
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131323
  • EUR 410.40
  • EUR 159.60
  • EUR 1195.20
  • EUR 594.00
  • EUR 360.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131324
  • EUR 393.60
  • EUR 159.60
  • EUR 1078.80
  • EUR 543.60
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131986
  • EUR 360.00
  • EUR 844.80
  • EUR 427.20
  • EUR 184.80
  • EUR 292.80
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131987
  • EUR 393.60
  • EUR 1011.60
  • EUR 526.80
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131988
  • EUR 393.60
  • EUR 1011.60
  • EUR 526.80
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx131989
  • EUR 427.20
  • EUR 1144.80
  • EUR 577.20
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx177189
  • EUR 360.00
  • EUR 159.60
  • EUR 961.20
  • EUR 510.00
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx177193
  • EUR 543.60
  • EUR 159.60
  • EUR 1545.60
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 6 (IL6) Antibody

20-abx177194
  • EUR 560.40
  • EUR 159.60
  • EUR 1612.80
  • EUR 760.80
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Eukaryotic Interleukin 6 (IL6)

4-EPA079Ca61
  • EUR 892.00
  • EUR 362.40
  • EUR 3014.98
  • EUR 1084.99
  • EUR 2049.98
  • EUR 672.00
  • EUR 7357.44
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Dog Interleukin 6 expressed in: 293F Cell

Eukaryotic Interleukin 6 (IL6)

4-EPA079Hu61
  • EUR 805.98
  • EUR 339.60
  • EUR 2692.42
  • EUR 977.47
  • EUR 1834.94
  • EUR 614.40
  • EUR 6551.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 6 expressed in: 293F cell

Eukaryotic Interleukin 6 (IL6)

4-EPA079Mu61
  • EUR 818.88
  • EUR 343.20
  • EUR 2740.80
  • EUR 993.60
  • EUR 1867.20
  • EUR 624.00
  • EUR 6672.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 6 expressed in: 293F cell

Eukaryotic Interleukin 6 (IL6)

4-EPA079Po61
  • EUR 829.63
  • EUR 345.60
  • EUR 2781.12
  • EUR 1007.04
  • EUR 1894.08
  • EUR 631.20
  • EUR 6772.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Interleukin 6 expressed in: 293F cell

Eukaryotic Interleukin 6 (IL6)

4-EPA079Ra61
  • EUR 859.74
  • EUR 354.00
  • EUR 2894.02
  • EUR 1044.67
  • EUR 1969.34
  • EUR 650.40
  • EUR 7055.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 6 expressed in: 293F cell

Active Interleukin 6 (IL6)

4-APA079Hu01
  • EUR 872.64
  • EUR 357.60
  • EUR 2942.40
  • EUR 1060.80
  • EUR 2001.60
  • EUR 660.00
  • EUR 7176.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 6 expressed in: E.coli

Active Interleukin 6 (IL6)

4-APA079Hu61
  • EUR 968.33
  • EUR 382.80
  • EUR 3301.25
  • EUR 1180.42
  • EUR 2240.83
  • EUR 723.60
  • EUR 8073.12
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 6 expressed in: 293F cell

Active Interleukin 6 (IL6)

4-APA079Mu61
  • EUR 942.53
  • EUR 375.60
  • EUR 3204.48
  • EUR 1148.16
  • EUR 2176.32
  • EUR 706.80
  • EUR 7831.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 6 expressed in: 293F cell

Active Interleukin 6 (IL6)

4-APA079Ra61
  • EUR 872.64
  • EUR 357.60
  • EUR 2942.40
  • EUR 1060.80
  • EUR 2001.60
  • EUR 660.00
  • EUR 7176.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 6 expressed in: 293F cell

Recombinant Interleukin 6 (IL6)

4-RPA079Ca01
  • EUR 646.85
  • EUR 296.40
  • EUR 2095.68
  • EUR 778.56
  • EUR 1437.12
  • EUR 508.80
  • EUR 5059.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Dog Interleukin 6 expressed in: E.coli

Recombinant Interleukin 6 (IL6)

4-RPA079Eq01
  • EUR 566.21
  • EUR 274.80
  • EUR 1793.28
  • EUR 677.76
  • EUR 1235.52
  • EUR 454.80
  • EUR 4303.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Horse Interleukin 6 expressed in: E.coli

Recombinant Interleukin 6 (IL6)

4-RPA079Hu01
  • EUR 537.18
  • EUR 267.60
  • EUR 1684.42
  • EUR 641.47
  • EUR 1162.94
  • EUR 434.40
  • EUR 4031.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Interleukin 6 expressed in: E.coli

Recombinant Interleukin 6 (IL6)

4-RPA079Mu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Interleukin 6 expressed in: E.coli

Recombinant Interleukin 6 (IL6)

4-RPA079Ov01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Sheep Interleukin 6 expressed in: E.coli

Recombinant Interleukin 6 (IL6)

4-RPA079Po01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Interleukin 6 expressed in: E.coli

Recombinant Interleukin 6 (IL6)

4-RPA079Ra01
  • EUR 590.94
  • EUR 282.00
  • EUR 1886.02
  • EUR 708.67
  • EUR 1297.34
  • EUR 470.40
  • EUR 4535.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Interleukin 6 expressed in: E.coli

Recombinant Interleukin 6 (IL6)

4-RPA079Rb01
  • EUR 590.94
  • EUR 282.00
  • EUR 1886.02
  • EUR 708.67
  • EUR 1297.34
  • EUR 470.40
  • EUR 4535.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rabbit Interleukin 6 expressed in: E.coli

Surprisingly, the protein synthesis was found intact in the Fe-def T cells as indicated by the level of comparable CD69 upregulation and cytokine production by T cells enough iron to stimulation with CD3 plus CD28 mAbs. Indeed, the high number of IL-2 was detected in the T cell supernatant Fe-def, which is accompanied by reduced cell surface expression of IL-2R. When we use the Fe-def T cells as in MLRS allogeneic, we observed that these cells acquire the accessory cell function and stimulates the proliferation of bystander T cells by providing IL-2

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