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Human β-defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells.

Human β-defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells.
Posted by Frank

AMP HBD-3 stimulates many functions of immune effector in myeloid cells and keratinocytes, especially through MAPK signaling cascade. Instead, HBD-3 reportedly neutralized the activation of T cells by hostile MAPK signs initiated by SDF-1α through CXCR4. By using a complementary proteomic and immunochemical approach, we investigate the possibility of the effect of HBD-3 stimulation in T cells and shows that HBD-3 induces the phosphorylation stat1 of tyrosine in 5 minutes but has not been able to induce MAPK activation.

The inclusion of PTPase inhibitors increases the phosphorylation induced by HBD-3 dramatically, shows that HBD-3 also stimulates PTPASE activity simultaneously. The increase in PTPASE activity was confirmed by showing that HBD-3 pressed Stat1 phosphorylation of tyrosine which was induced by IFN-γ but not Stat1 Serine and ERK1 / 2 threonine phosphorylation and stimulates the translocation of shp-2 into the nucleus within 15 minutes.

The signaling path initiated by HBD-3 can lead to improving the effector function of T cells that are secretly during TCR activation, such as an increase in IL-2 and IL-10, but not γ-γ secretions. Thus, HBD-3 initiated special cascade signaling special lineage in various cells involved in the host defense and inducing cascade signaling tyrosine kinase and tyrosine phosphatase which can activate simultaneous T cells targeted and inhibit their response to other immune mediators. In addition, these results indicate that evolutionary conserved peptides, which show a broad spectrum of antimicrobial and immunomodulators, serves to integrate innate and adaptive immunity.

Brief Communication: Human Limfotropic Virus Type 1 Coinfection modulated cytokine synthesis by peripheral blood mononuclear cells from individuals infected by HIV.

HIV-1 and HTLV-1 infect CD4 (+) t lymphocytes but few are known about the impact of coinfection on the patient’s immune response. In this study we have evaluated the production of spontaneous interleukin (IL) -2, IL-4, IL-6, and IL-10 and Interferon (IFN) -γ with peripheral blood mononuclear cell culture (PBMC) obtained from infected patients by HTLV-1, HIV-1, or both viruses.

We have observed that HIV / HTLV co-infected individuals presented higher IL-2 and IFN-γ production significantly compared to single-infected HIV individuals and HTLV. The synthesis of IL-6 and IL-10 is similar in all infected groups, but HTLV infected individuals presents lower IL-4 production. These results indicate that HIV / HTLV co-infected individuals present a higher production profile of the T-1 cytokine, showing the dominant stimulus HTLV-1 detrimental to HIV-1 infection.

Human β-defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells.

The 16th meeting of the Internityity Institute of Myology (IIM), October 17-20, 2019, Assisi, Italy unites scientists, Pharma and representatives of the patient’s organization that discusses the results of new muscle research. International famous speakers internationally present the progress of muscle development, homeostasis, metabolism, and disease. The selected speaker among the abstracts sent to present their new data which is not published in seven scientific sessions.

The remaining abstract is exhibited in two poster sessions. The young trainee where it was directly involved in the selection of major speakers, scientific and roundabout sessions adapted to the interests of their colleagues. The broad Italian, European and American audience participates with different initiatives. This meeting allows muscle biological researchers to discuss scientific ideas and collaboration that aims to better understand the underlying mechanism of muscle disease to develop a better therapeutic strategy.

Active participation of young training participants is facilitated by a friendly and inclusive atmosphere, which encourages living discussions identifying the fields of myology research that appears and stimulates scientific cross fertilization. The meeting was successful and the IIM community would continue to advance significant contributions to understanding muscle development and function, the pathogenesis of muscle disease and the development of a new therapy approach. Here, we report abstracts from meetings that describe the results of novels from basic research, translation, and clinical, which confirms that the field of myology is strong and healthy.

Leflunomide is immunomodulated drugs that have been clinically used for the treatment of rheumatoid arthritis and other immune system disorders. As a continuation of our previous work, four analog leflunomide novels (6A, 6B, 7A and 7B) were synthesized; Here, the Imidazolyl group has replaced Moiety isoxazolyl, while the 4-trifluoromethylphenyl group has been maintained.

This analog is synthesized and investigated in vitro for their immunomodulation activity by examining the proliferation of human lymphocytes and determining the concentration of interferon-γ cytokines in human lymphocyte cells. For this purpose, 5 x 10 (4) human lymphocyte cells are incubated at 37 ° C within 5% CO (2) with phytohemagglutinin and one analog (concentration starting 1 to 100 mm), negative control or cyclosporine (0.1 mm) ).

The effect of compounds in the proliferation of lymphocytes and interferon-γ (IFN-γ) production is determined using the MTT and ELISA test, respectively. All compounds found to have a significant effect on lymphocyte proliferation and IFN-γ production compared to negative control. However, the effect of compounds is weaker than positive control.

IL-10 (Cytokine synthesis inhibitory factor) (PE)

MBS6404423-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (PE)

MBS6404423-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (AP)

MBS6404424-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (AP)

MBS6404424-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (PE)

MBS6404434-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (PE)

MBS6404434-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (APC)

MBS6404403-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (APC)

MBS6404403-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (HRP)

MBS6404406-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (HRP)

MBS6404406-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (APC)

MBS6404414-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (APC)

MBS6404414-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (HRP)

MBS6404417-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (HRP)

MBS6404417-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (APC)

MBS6404425-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (APC)

MBS6404425-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (HRP)

MBS6404428-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (HRP)

MBS6404428-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (FITC)

MBS6404405-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (FITC)

MBS6404405-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (FITC)

MBS6404416-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (FITC)

MBS6404416-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (FITC)

MBS6404427-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (FITC)

MBS6404427-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (Biotin)

MBS6404404-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (Biotin)

MBS6404404-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (Biotin)

MBS6404415-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (Biotin)

MBS6404415-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (Biotin)

MBS6404426-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (Biotin)

MBS6404426-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6404407-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6404407-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6404408-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6404408-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6404409-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6404409-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6404410-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6404410-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6404411-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6404411-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6404418-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6404418-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6404419-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6404419-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6404420-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6404420-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6404421-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6404421-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6404422-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6404422-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6404429-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6404429-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6404430-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6404430-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6404431-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6404431-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6404432-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6404432-5x01mL 5x0.1mL
EUR 3855

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6404433-01mL 0.1mL
EUR 890

IL-10 (Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6404433-5x01mL 5x0.1mL
EUR 3855

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS6507809-01mg 0.1mg
EUR 920

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS6507809-05mg 0.5mg
EUR 1870

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS6507809-5x05mg 5x0.5mg
EUR 8275

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (AP)

MBS6482908-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (AP)

MBS6482908-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (PE)

MBS6482918-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (PE)

MBS6482918-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (AP)

MBS6482941-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (AP)

MBS6482941-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (PE)

MBS6482951-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (PE)

MBS6482951-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (AP)

MBS6482952-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (AP)

MBS6482952-5x01mL 5x0.1mL
EUR 3560

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (PE)

MBS6482962-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (PE)

MBS6482962-5x01mL 5x0.1mL
EUR 3560

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (APC)

MBS6482909-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (APC)

MBS6482909-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (HRP)

MBS6482912-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (HRP)

MBS6482912-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (APC)

MBS6482942-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (APC)

MBS6482942-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (HRP)

MBS6482945-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (HRP)

MBS6482945-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (APC)

MBS6482953-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (APC)

MBS6482953-5x01mL 5x0.1mL
EUR 3560

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (HRP)

MBS6482956-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (HRP)

MBS6482956-5x01mL 5x0.1mL
EUR 3560

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (AP)

MBS6309838-02mL 0.2mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (AP)

MBS6309838-5x02mL 5x0.2mL
EUR 4250

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (APC)

MBS6309839-02mL 0.2mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (APC)

MBS6309839-5x02mL 5x0.2mL
EUR 4250

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (PE)

MBS6309848-02mL 0.2mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (PE)

MBS6309848-5x02mL 5x0.2mL
EUR 4250

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (FITC)

MBS6482911-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (FITC)

MBS6482911-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (FITC)

MBS6482944-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (FITC)

MBS6482944-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (FITC)

MBS6482955-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (FITC)

MBS6482955-5x01mL 5x0.1mL
EUR 3560

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (FITC)

MBS6309841-02mL 0.2mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (FITC)

MBS6309841-5x02mL 5x0.2mL
EUR 4250

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (Biotin)

MBS6482910-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (Biotin)

MBS6482910-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (Biotin)

MBS6482943-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (Biotin)

MBS6482943-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (Biotin)

MBS6482954-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (Biotin)

MBS6482954-5x01mL 5x0.1mL
EUR 3560

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (Biotin)

MBS6309840-02mL 0.2mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (Biotin)

MBS6309840-5x02mL 5x0.2mL
EUR 4250

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (AP)

MBS6131836-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (AP)

MBS6131836-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (PE)

MBS6158351-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (PE)

MBS6158351-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) APC

MBS6137139-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) APC

MBS6137139-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (FITC)

MBS6147745-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (FITC)

MBS6147745-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (HRP)

MBS6153048-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (HRP)

MBS6153048-5x01mL 5x0.1mL
EUR 3800

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 405)

MBS6482913-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 405)

MBS6482913-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 490)

MBS6482914-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 490)

MBS6482914-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 550)

MBS6482915-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 550)

MBS6482915-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 650)

MBS6482916-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 650)

MBS6482916-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 750)

MBS6482917-01mL 0.1mL
EUR 1100

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 750)

MBS6482917-5x01mL 5x0.1mL
EUR 4810

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 405)

MBS6482946-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 405)

MBS6482946-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 490)

MBS6482947-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 490)

MBS6482947-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 550)

MBS6482948-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 550)

MBS6482948-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 650)

MBS6482949-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 650)

MBS6482949-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 750)

MBS6482950-01mL 0.1mL
EUR 635

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 750)

MBS6482950-5x01mL 5x0.1mL
EUR 2700

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 405)

MBS6482957-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 405)

MBS6482957-5x01mL 5x0.1mL
EUR 3560

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 490)

MBS6482958-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 490)

MBS6482958-5x01mL 5x0.1mL
EUR 3560

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 550)

MBS6482959-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 550)

MBS6482959-5x01mL 5x0.1mL
EUR 3560

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 650)

MBS6482960-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 650)

MBS6482960-5x01mL 5x0.1mL
EUR 3560

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 750)

MBS6482961-01mL 0.1mL
EUR 825

Interleukin 10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) (MaxLight 750)

MBS6482961-5x01mL 5x0.1mL
EUR 3560

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (Biotin)

MBS6142442-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (Biotin)

MBS6142442-5x01mL 5x0.1mL
EUR 3800

Interleukin 10, Low Endotoxin (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS606458-05mg 0.5mg
EUR 1000

Interleukin 10, Low Endotoxin (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS606458-5x05mg 5x0.5mg
EUR 4345

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6309843-01mL 0.1mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 405)

MBS6309843-5x01mL 5x0.1mL
EUR 4250

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6309844-01mL 0.1mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 490)

MBS6309844-5x01mL 5x0.1mL
EUR 4250

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6309845-01mL 0.1mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 550)

MBS6309845-5x01mL 5x0.1mL
EUR 4250

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6309846-01mL 0.1mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 650)

MBS6309846-5x01mL 5x0.1mL
EUR 4250

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6309847-01mL 0.1mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (MaxLight 750)

MBS6309847-5x01mL 5x0.1mL
EUR 4250

Interleukin 10, Recombinant, Rat (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650805-001mg 0.01mg
EUR 705

Interleukin 10, Recombinant, Rat (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650805-5x001mg 5x0.01mg
EUR 3015

Interleukin 10, Recombinant, Rat (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650378-0002mg 0.002mg
EUR 340

Interleukin 10, Recombinant, Rat (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650378-001mg 0.01mg
EUR 490

Interleukin 10, Recombinant, Rat (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650378-5x001mg 5x0.01mg
EUR 2055

Interleukin 10, Recombinant, Mouse (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650888-0002mg 0.002mg
EUR 340

Interleukin 10, Recombinant, Mouse (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650888-001mg 0.01mg
EUR 490

Interleukin 10, Recombinant, Mouse (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650888-5x001mg 5x0.01mg
EUR 2055

Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650373-0005mg 0.005mg
EUR 720

Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650373-5x0005mg 5x0.005mg
EUR 3015

Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650042-01mg 0.1mg
EUR 475

Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650042-5x01mg 5x0.1mg
EUR 1990

Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650143-0002mg 0.002mg
EUR 375

Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650143-001mg 0.01mg
EUR 625

Interleukin 10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF)

MBS650143-5x001mg 5x0.01mg
EUR 2665

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (Azide free) (HRP)

MBS6309842-02mL 0.2mL
EUR 980

IL10, ID (IL10, Interleukin-10, Cytokine synthesis inhibitory factor) (Azide free) (HRP)

MBS6309842-5x02mL 5x0.2mL
EUR 4250

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 490)

MBS6201374-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 490)

MBS6201374-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 550)

MBS6212049-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 550)

MBS6212049-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 405)

MBS6190699-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 405)

MBS6190699-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 650)

MBS6222724-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 650)

MBS6222724-5x01mL 5x0.1mL
EUR 3800

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 750)

MBS6233399-01mL 0.1(mL
EUR 875

IL10 (Interleukin-10, Interleukin 10, Cytokine Synthesis Inhibitory Factor) (MaxLight 750)

MBS6233399-5x01mL 5x0.1mL
EUR 3800

Interleukin-10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Il10, Il-10) (AP)

MBS6269693-01mL 0.1mL
EUR 1005

Interleukin-10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Il10, Il-10) (AP)

MBS6269693-5x01mL 5x0.1mL
EUR 4370

Interleukin-10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Il10, Il-10) (APC)

MBS6269694-01mL 0.1mL
EUR 1005

Interleukin-10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Il10, Il-10) (APC)

MBS6269694-5x01mL 5x0.1mL
EUR 4370

Interleukin-10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Il10, Il-10) (HRP)

MBS6269697-01mL 0.1mL
EUR 1005

Interleukin-10 (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Il10, Il-10) (HRP)

MBS6269697-5x01mL 5x0.1mL
EUR 4370

Some differences between 6A compounds, 6B, 7A and 7b are seen in lymphocyte proliferation and cytokine production. Compound 6A (R = CH (3) containing trifluoromethylanine moiety) suppresses lymphocyte proliferation and IFN-γ production with potential comparable to positive control. Therefore, further studies to evaluate the effect of compounds in clinical conditions are recommended.

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